Is Elevated Mean Platelet Volume Associated With a Worse Outcome in Patients With Acute Ischemic Cerebrovascular Events?

Abstract

Background and Purpose-Increased mean platelet volume (MPV), indicating higher platelet reactivity, is associated with an increased risk of myocardial infarction. Higher levels of MPV have been found in patients with acute ischemic stroke than in control subjects. Data from smaller studies regarding an association between MPV and stroke severity and outcome have been controversial. If such an association exists, MPV might help to identify patients at increased risk of a severe course of acute cerebrovascular disease. Methods-Within a multicenter, cross-sectional study nested in a cohort, we analyzed the relation between MPV and stroke severity as determined by the modified Rankin Scale after 1 week in 776 patients with acute ischemic stroke or transient ischemic attack. By multivariate logistic regression modeling, we determined the influence of MPV on stroke severity, adjusting for potential confounding factors. Results-Patients within the highest quintile of MPV had a significantly higher risk of suffering a severe stroke, defined as modified Rankin Scale score of 3 to 6, compared with patients within the lowest quintile (odds ratioϭ2.6; 95% confidence interval, 1.6 to 4.1; PϽ0.001). This association remained significant after adjustment for possible confounding factors (odds ratioϭ2.2; 95% confidence interval, 1.2 to 4.0; Pϭ0.013). Conclusions-Our results indicate that an elevated MPV is associated with a worse outcome for acute ischemic cerebrovascular events independent of other clinical parameters.

Association of Mean Platelet Volume With The Degree of Retinopathy in Patients with Diabetes Mellitus

“…Thus, platelets exhibit hyper-responsiveness to ADP-or collagen-induced aggregation (1). Various studies reported that increased levels of MPV is an independent risk factor for arterial thrombotic events such as myocardial infarction and cerebral thromboembolism (2)(3)(4)(5). The patients with diabetes mellitus are at increased risk of macrovascular and microvascular complications.…”

Study the relationship between nasal polyps, platelet count, mean platelet volume, neutrophil/lymphocyte ratio in patients attending otolaryngology OPD in a tertiary care teaching hospital, West Bengal

“…15 An increased level of MPV was found to be related to various pathological conditions, including cardiovascular and cerebrovascular disorders, and deep venous thrombosis. [46][47][48] MPV was also investigated in some studies related to otolaryngological pathologies. Poorey et al reported an increased level of MPV due to chronic nasal obstruction in patients with deviated nasal septum.…”

Conservation and viability of refrigerated platelet-rich plasma from New Zealand rabbits

“…Factors such as the technology used, variable pre-analytical effects of anticoagulants, temperature, and time of storage of the material all cause interferences when determining the MPV (GULATI et al, 2002;VOGELAAR et al, 2002). Using sodium citrate as an anticoagulant retains the platelets with a spherical shape, which could increase the MPV (MACEY et al, 2002;GREISENEGGER et al, 2004). Bulky and aggregate platelets have higher MPV values and decreased counts (RACCHI; RAPEZZI, 2001;BAIN;PATH, 2005).…”