2013
DOI: 10.1590/1516-4446-2013-1190 View full text |Buy / Rent full text
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Abstract: Objective: To investigate whether inpatients with disorganized schizophrenia are more resistant to treatment. Method: Eighty-five inpatients were assessed at admission and at discharge for schizophrenia subtype, symptom severity, and treatment resistance criteria. Results: Disorganized patients were significantly more treatment-resistant than paranoid patients (60%, p = 0.001), and presented worse scores on the Positive and Negative Syndrome Scale (PANSS), the Clinical Global Impression Scale (CGI-S), and the … Show more

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“…Nevertheless, lower mortality rates have been found in CLZ users compared to all other antipsychotics and compared to former CLZ users and to users of other antipsychotics , suggesting long‐term good physical tolerability of CLZ. Another factor possibly explaining our results is that patient characteristics independent of disease stage may partially explain CLZ treatment response: Some research hints that factors such as abundant negative symptoms, a longer duration of untreated psychosis , young age at onset , and disorganized subtype of SCZ might predict TRS early in the disease.…”
Section: Discussionmentioning
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“…Nevertheless, lower mortality rates have been found in CLZ users compared to all other antipsychotics and compared to former CLZ users and to users of other antipsychotics , suggesting long‐term good physical tolerability of CLZ. Another factor possibly explaining our results is that patient characteristics independent of disease stage may partially explain CLZ treatment response: Some research hints that factors such as abundant negative symptoms, a longer duration of untreated psychosis , young age at onset , and disorganized subtype of SCZ might predict TRS early in the disease.…”
Section: Discussionmentioning
“…Previous studies investigating risk factors for treatment resistance (TR) have utilized clozapine prescription rates as a proxy measure of TR (Nielsen et al 2012 b ; Stroup et al 2014; Schneider et al 2015); however, given the under-utilization of clozapine in clinical practice, such studies do not measure all people with TR. Although, a few potential risk factors for TR, such as poor premorbid functioning, living in less urban areas, co-morbid personality disorder, longer duration of untreated psychosis (DUP), greater severity of negative symptoms, and a younger age of illness onset have been suggested (Vanelle et al 1994; Meltzer, 1997; Schennach et al 2012; Ortiz et al 2013; Frank et al 2015; Martin & Mowry, 2016; Wimberley et al 2016), the predictive value of specific clinical and demographic factors on TR in first-episode schizophrenia has not yet been widely investigated (Lin et al 2008). Further, while there is a large literature investigating predictors of treatment response and remission from illness onset (Menezes et al 2006; Carbon & Correll, 2014), TR has not been examined longitudinally as an outcome measure in first-episode psychosis (FEP).…”
Section: Introductionmentioning
“…A study assessing the relationship between symptom dimensions and functioning also found that disorganized symptoms had the highest effect on functioning and prevented patients from achieving remission (Ortiz et al 2015). Furthermore, in a study assessing treatment response of disorganized schizophrenia inpatients, it was found that these patients were more treatment-resistant in comparison with paranoid schizophrenia inpatients and had more severe PANSS scores (Ortiz et al 2013). Thus, the Arabic MINI-Mod-K and PANSS can capture this important feature in the Arab schizophrenia patients and thus be a reliable measure to diagnose and properly assess this group of patients.…”
Section: Predictors Of Panss Total and Subscales Scoresmentioning