2004
DOI: 10.1515/cclm.2004.052
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Abstract: In idiopathic recurrent urolithiasis (IRCU) calcium oxalate and calcium phosphate are components of stones. It is not sufficiently known whether in urine the nucleation (liquid-solid transition) of each salt requires a different environment, if so which environment, and whether there is an impact on stone formation. Nucleation was induced by in vitro addition of oxalate or calcium to post-test meal load whole urine of male stone patients (n=48), showing normal daily and baseline fasting oxaluria. The maximally… Show more

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Cited by 11 publications
(9 citation statements)
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References 30 publications
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“…The overlap of participants in the present and previous studies, using different strategies and outcomes [1,5,18], was 80 - 95%. As a search for the mechanism(s) underlying ROS production and ROS nature was not in the focus of present work, overproduction of ROS (by cells during hypoxia-induced ATP degradation [19]) was taken as reflected by increase of urinary hypoxanthine, and ROS excess-mediated damage of lipids and lipid-containing cell membranes, other molecules and genes [11,12,20] as reflected by increase of urinary MDA; low plasma uric acid, the dominant antioxidant component of human plasma [5,21], was taken as indicating antioxidant deficiency.…”
Section: Methodscontrasting
confidence: 53%
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“…The overlap of participants in the present and previous studies, using different strategies and outcomes [1,5,18], was 80 - 95%. As a search for the mechanism(s) underlying ROS production and ROS nature was not in the focus of present work, overproduction of ROS (by cells during hypoxia-induced ATP degradation [19]) was taken as reflected by increase of urinary hypoxanthine, and ROS excess-mediated damage of lipids and lipid-containing cell membranes, other molecules and genes [11,12,20] as reflected by increase of urinary MDA; low plasma uric acid, the dominant antioxidant component of human plasma [5,21], was taken as indicating antioxidant deficiency.…”
Section: Methodscontrasting
confidence: 53%
“…Note the absence of a P peak. Reproduced from [18] with kind permission of Walter De Gruyter, Berlin, Germany.…”
Section: Discussionmentioning
confidence: 99%
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“…In addition, Schwille et al . found that crystal nucleation in postprandial urine was more accelerated in CaP stones than in CaOx stones . Clinically, CaP stones are considered to score much higher on the HU scale than CaOx stones; that is, CaP stones are much harder and more difficult to break into pieces during surgical treatments.…”
Section: Discussionmentioning
confidence: 99%