Is Atherosclerosis an Allergic Disease?

Binder, Christoph J.; Witztum, Joseph L.

doi:10.1161/res.0b013e31823a8c44

Cited by 10 publications

(7 citation statements)

References 19 publications

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“…In subjects without baseline cardiovascular diseases, the elevation of total IgE was significantly associated with increased cardiovascular mortality risk, whereas no association was found in subjects with baseline cardiovascular diseases. Considering that IgE activates an increasing number of mast cells, interact with immune cells (i.e., monocytes and macrophages), and influence generic determinants of atherosclerotic disease [5,6,7,19], IgE levels in subjects who are free of clinical cardiovascular disease may be an important marker for subsequent cardiovascular events. In patients who already have cardiovascular diseases, on the other hand, IgE increase may be not specific for predicting cardiovascular mortality risk.…”

Section: Discussionmentioning

confidence: 99%

“…Over the past decades, a growing body of evidence has generated new interest in a potential association between total IgE levels and cardiovascular disease [4]. The proposed mechanism is both IgE-independent and -dependent, and involves mast cells that trigger the release of vasoactive inflammation mediators, contributing to the development and progression of myocardial ischemia and thrombosis [5,6,7]. Several cross-sectional studies have demonstrated elevated total serum IgE levels in patients with acute myocardial infarction (AMI), sudden cardiac arrest, and coronary artery disease [8,9,10].…”

Section: Introductionmentioning

confidence: 99%

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Risk of Cardiovascular Mortality in Relation to Increased Total Serum IgE Levels in Older Adults: A Population-Based Cohort Study

Min

2019

IJERPH

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Background: Despite a potential link between immunoglobulin E (IgE) levels and cardiovascular disease, the effect of elevated total IgE levels on long-term mortality risk remains unclear. We prospectively investigated the association between total serum IgE levels and all-cause and cardiovascular mortality in US adults. Methods: We analyzed data from the 2005–2006 National Health and Nutrition Examination Survey (NHANES) and the NHANES (2005–2006) Linked Mortality Public File. The 2005–2006 NHANES data of 1496 older adults aged ≥50 years and who underwent a serum total IgE antibody test in the initial survey were included. Results: After a median follow-up of 119 months, a significant association was observed between total serum IgE levels and cardiovascular mortality, with subjects with the highest total IgE exhibiting a 3.19-fold (HR = 3.19; 95% confidence interval: 1.71–5.96) increase in the risk of cardiovascular mortality compared with those with the lowest total IgE (≤16.80 kU/L). Furthermore, the mortality rate increased with an increase in total IgE levels, regardless of baseline history of cardiovascular diseases (e.g., myocardial infarction, stroke, and noninvasively diagnosed large-vessel peripheral arterial disease). Conclusions: This finding suggests that the elevation of IgE levels may be a risk factor for increased cardiovascular mortality.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Risk of Cardiovascular Mortality in Relation to Increased Total Serum IgE Levels in Older Adults: A Population-Based Cohort Study

Min

2019

IJERPH

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“…These inflammatory mediators actively contribute to the preceding development of atherosclerotic plaque, the process of its destabilization and subsequent erosion or rupture as well 27 - 30 . Second, IgE could activate monocytes, macrophages or other types of immune cells to facilitate the pathogenesis of atherosclerosis, by binding to the high-affinity IgE receptor and toll-like receptor 4 16 , 31 . Last but not the least, the close locations of two genes affecting atheromatous plaque formation and total serum IgE concentrations may be a possible explanation of the relationship between total IgE and coronary heart disease 32 - 34 .…”

Section: Discussionmentioning

confidence: 99%

The Relationship of Serum Antigen-Specific and Total Immunoglobulin E with Adult Cardiovascular Diseases

Wang

Guo

et al. 2018

Int. J. Med. Sci.

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Background: The relationship of serum antigen-specific immunoglobulin E (IgE) with cardiovascular diseases (CVDs) remains poorly understood. This study aimed to explore the association of antigen-specific and total IgE with CVDs using data derived from the National Health and Nutrition Examination Survey (NHANES) 2005-2006.Methods and Results: The association of serum total or antigen-specific IgE levels with CVDs was analyzed by survey-weighted logistic regression modeling, adjusted by age, sex, race, education, body mass index, blood pressure, total cholesterol, C-reactive protein, homocysteine, diabetes, smoking, and alcohol consumption. 4953 subjects were included. Coronary heart disease was significantly related to serum total IgE levels. The association of serum total IgE levels with coronary heart disease was further validated by negative, ≥1 and 1-6 positive antigen-specific IgE. Myocardial infarction was positively associated with serum total IgE levels only when all antigen-specific IgE were negative, but inversely associated with serum total IgE when plant-specific IgE test results were positive. More specifically, myocardial infarction was also inversely related to positive oak, birch, or peanut-specific IgE. In addition, serum total IgE are positively associated with angina when at least one specific IgE were positive.Conclusions: Serum antigen-specific IgE, as well as total IgE, is significantly associated with CVDs independently of a long list of established cardiovascular risk factors, which is more informative than total IgE per se.

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“…Do conventional B-2 cells respond to activation and produce antibodies that directly regulate atherosclerosis in a protective or pathogenic way? Might atherosclerosis be an allergic disease (Binder and Witztum, 2011)?…”

Section: B-2 B Cells In Atherosclerosismentioning

confidence: 99%

B cell subsets in atherosclerosis

2012

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Atherosclerosis, the underlying cause of heart attacks and strokes, is a chronic inflammatory disease of the artery wall. Immune cells, including lymphocytes modulate atherosclerotic lesion development through interconnected mechanisms. Elegant studies over the past decades have begun to unravel a role for B cells in atherosclerosis. Recent findings provide evidence that B cell effects on atherosclerosis may be subset-dependent. B-1a B cells have been reported to protect from atherosclerosis by secretion of natural IgM antibodies. Conventional B-2 B cells can promote atherosclerosis through less clearly defined mechanism that may involve CD4 T cells. Yet, there may be other populations of B cells within these subsets with different phenotypes altering their impact on atherosclerosis. Additionally, the role of B cell subsets in atherosclerosis may depend on their environmental niche and/or the stage of atherogenesis. This review will highlight key findings in the evolving field of B cells and atherosclerosis and touch on the potential and importance of translating these findings to human disease.

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Is Atherosclerosis an Allergic Disease?

Cited by 10 publications

References 19 publications

Risk of Cardiovascular Mortality in Relation to Increased Total Serum IgE Levels in Older Adults: A Population-Based Cohort Study

Risk of Cardiovascular Mortality in Relation to Increased Total Serum IgE Levels in Older Adults: A Population-Based Cohort Study

The Relationship of Serum Antigen-Specific and Total Immunoglobulin E with Adult Cardiovascular Diseases

B cell subsets in atherosclerosis

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