Is 3D Printing of Pharmaceuticals a Disruptor or Enabler?

Liang, Kun; Brambilla, Davide; Leroux, Jean‐Christophe

doi:10.1002/adma.201805680

Cited by 49 publications

(30 citation statements)

References 29 publications

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“…A potential technology to produce the aforementioned meshes is 3D printing. This technology allows clinicians to prepare devices adapted to patient's anatomy and requirements [14][15][16][17]. Furthermore, a wide range of materials can be used for 3D printing applications.…”

Section: Introductionmentioning

confidence: 99%

3D Printing of Drug-Loaded Thermoplastic Polyurethane Meshes: A Potential Material for Soft Tissue Reinforcement in Vaginal Surgery

et al. 2020

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Current strategies to treat pelvic organ prolapse (POP) or stress urinary incontinence (SUI), include the surgical implantation of vaginal meshes. Recently, there have been multiple reports of issues generated by these meshes conventionally made of poly(propylene). This material is not the ideal candidate, due to its mechanical properties leading to complications such as chronic pain and infection. In the present manuscript, we propose the use of an alternative material, thermoplastic polyurethane (TPU), loaded with an antibiotic in combination with fused deposition modelling (FDM) to prepare safer vaginal meshes. For this purpose, TPU filaments containing levofloxacin (LFX) in various concentrations (e.g., 0.25%, 0.5%, and 1%) were produced by extrusion. These filaments were used to 3D print vaginal meshes. The printed meshes were fully characterized through different tests/analyses such as fracture force studies, attenuated total reflection-Fourier transform infrared, thermal analysis, scanning electron microscopy, X-ray microcomputed tomography (μCT), release studies and microbiology testing. The results showed that LFX was uniformly distributed within the TPU matrix, regardless the concentration loaded. The mechanical properties showed that poly(propylene) (PP) is a tougher material with a lower elasticity than TPU, which seemed to be a more suitable material due to its elasticity. In addition, the printed meshes showed a significant bacteriostatic activity on both Staphylococcus aureus and Escherichia coli cultures, minimising the risk of infection after implanting them. Therefore, the incorporation of LFX to the TPU matrix can be used to prepare anti-infective vaginal meshes with enhanced mechanical properties compared with current PP vaginal meshes.

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Section: Introductionmentioning

confidence: 99%

3D Printing of Drug-Loaded Thermoplastic Polyurethane Meshes: A Potential Material for Soft Tissue Reinforcement in Vaginal Surgery

et al. 2020

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“…In this regard, three-dimensional (3D) printing may offer an elegant and practical solution to the problem. 3D printing is an additive manufacturing technique in which an object is built up in a layer-by-layer manner [10][11][12][13][14], based on a 3D model designed using computer-aided design (CAD) software [15][16][17][18][19]. At present, 3D printing is often used to produce engineering prototypes due to its fast production speed and cost-effectiveness [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients

et al. 2020

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Visual impairment and blindness affects 285 million people worldwide, resulting in a high public health burden. This study reports, for the first time, the use of three-dimensional (3D) printing to create orally disintegrating printlets (ODPs) suited for patients with visual impairment. Printlets were designed with Braille and Moon patterns on their surface, enabling patients to identify medications when taken out of their original packaging. Printlets with different shapes were fabricated to offer additional information, such as the medication indication or its dosing regimen. Despite the presence of the patterns, the printlets retained their original mechanical properties and dissolution characteristics, wherein all the printlets disintegrated within ~5 s, avoiding the need for water and facilitating self-administration of medications. Moreover, the readability of the printlets was verified by a blind person. Overall, this novel and practical approach should reduce medication errors and improve medication adherence in patients with visual impairment.

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“…Therefore, the design of personalized dosage forms that contain multiple drugs with differential release profiles could be beneficial for enhanced therapeutic effect and reduced toxicity . To address these limitations in drug formulation and delivery, pharmaceutical scientists have begun to explore AM technologies to fabricate advanced pharmaceutical products ( Figure ) . Two main themes are emerging within AM of precision DDS: precision in drug release kinetics and precision to the individual patient.…”

Section: Applications Of Precision Biomaterialsmentioning

confidence: 99%

“…[190] To address these limitations in drug formulation and delivery, pharmaceutical scientists have begun to explore AM technologies to fabricate advanced pharmaceutical products (Figure 5). [191,192] Two main themes are emerging within AM of precision DDS: precision in drug release kinetics and precision to the individual patient.…”

Section: Personalized Drug Delivery Systemsmentioning

confidence: 99%

“…The first FDA-approved pharmaceutical fabricated by AM was SPRITAM for the treatment of epilepsy marketed by Aprecia Pharmaceuticals in 2015. [191] The drug product is formed by 3D printing or binder jetting, whereby a binder solution is dropped onto a powder layer containing levetiracetam and excipient particles that are joined together by the binder. In a layer-by-layer process, additional drug and excipient powder is deposited and bound to build the final tablet.…”

Section: Personalized Drug Delivery Systemsmentioning

confidence: 99%

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Additive Manufacturing of Precision Biomaterials

2019

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Biomaterials play a critical role in modern medicine as surgical guides, implants for tissue repair, and as drug delivery systems. The emerging paradigm of precision medicine exploits individual patient information to tailor clinical therapy. While the main focus of precision medicine to date is the design of improved pharmaceutical treatments based on “‐omics” data, the concept extends to all forms of customized medical care. This includes the design of precision biomaterials that are tailored to meet specific patient needs. Additive manufacturing (AM) enables free‐form manufacturing and mass customization, and is a critical enabling technology for the clinical implementation of precision biomaterials. Materials scientists and engineers can contribute to the realization of precision biomaterials by developing new AM technologies, synthesizing advanced (bio)materials for AM, and improving medical‐image‐based digital design. As the field matures, AM is poised to provide patient‐specific tissue and organ substitutes, reproducible microtissues for drug screening and disease modeling, personalized drug delivery systems, as well as customized medical devices.

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Is 3D Printing of Pharmaceuticals a Disruptor or Enabler?

Cited by 49 publications

References 29 publications

3D Printing of Drug-Loaded Thermoplastic Polyurethane Meshes: A Potential Material for Soft Tissue Reinforcement in Vaginal Surgery

3D Printing of Drug-Loaded Thermoplastic Polyurethane Meshes: A Potential Material for Soft Tissue Reinforcement in Vaginal Surgery

3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients

Additive Manufacturing of Precision Biomaterials

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