Biochemical Pharmacology volume 79, issue 10, P1496-1505 2010 DOI: 10.1016/j.bcp.2010.01.017 View full text
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Tsuyoshi Fujita, Akiyoshi Kishimoto, Hideki Shiba, Kouichi Hayashida, Mikihito Kajiya, Yuushi Uchida, Shinji Matsuda, Katsuhiro Takeda, Kazuhisa Ouhara, Hiroyuki Kawaguchi, Yoshimitsu Abiko, Hidemi Kurihara

Abstract: Irsogladine maleate (IM) counters Aggregatibacter actinomycetemcomitans-induced reduction of the gap junction intercellular communication and the expression of zonula occludens-1, which is a major tight junction structured protein, in cultured human gingival epithelial cells (HGEC). In addition, IM obviates the A. actinomycetemcomitans-induced increase in interleukin (IL)-8 levels in HGEC. Thus, by regulating the intercellular junctional complex and chemokine secretion in HGEC, IM may be useful to prevent peri…

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