Irritative effects of fumes and aerosols of bitumen on the airways: results of a cross-shift study

Raulf‐Heimsoth, Monika; Pesch, Beate; Schott, Klaus; Kappler, Martin; Preuss, Ralf; Marczyński, Boleslaw; Angerer, Jürgen; Rihs, Hans Peter; Hahn, Jens‐Uwe; Merget, R.; Brüning, Thomas

doi:10.1007/s00204-006-0115-z

Cited by 33 publications

(21 citation statements)

References 22 publications

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“…This conclusion is further confirmed by the results of multiple linear regression analysis (Table 5) and is consistent with the findings of other studies. 1,4,5,8,10,14,15 The findings of the current study are not consistent with the findings of some other studies. 12,18,19 While the exact reasons for these discrepancies are not clear, factors such as difference in the air concentration of asphalt fumes in different studies, asphalt temperature, the season when the study was conducted, air velocity, 26 direction of wind, 34 the method asphalt was scattered (manual or mechanical), the emission model of asphalt vapors and fumes, study sample size, how confounding variables were controlled, type of statistical analysis, workload, and the personal protective equipment used may explain in part, this issue.…”

Section: Dependent Variable β (95% Ci)contrasting

confidence: 99%

“…1,[4][5][6] Additionally, asphalt workers are exposed to emissions from the exhaust of passing vehicles. 4,[7][8][9] Respiratory effects of exposure to asphalt fume have been evaluated in a few studies. 5 However, conclusive results have not been obtained yet.…”

Section: A R T I C L Ementioning

confidence: 99%

“…5,8,[10][11][12][13] Some studies showed that exposure to asphalt fumes is associated with the incidence of respiratory symptoms. 4,10,14,15 Moreover, bronchitis and emphysema have been reported in asphalt workers.…”

Section: A R T I C L Ementioning

confidence: 99%

See 2 more Smart Citations

Respiratory Symptoms and Lung Functional Impairments Associated with Occupational Exposure to Asphalt Fumes

Neghab¹,

Derisi²,

Hassanzadeh³

2015

Int J Occup Environ Med

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Section: Dependent Variable β (95% Ci)contrasting

confidence: 99%

Section: A R T I C L Ementioning

confidence: 99%

See 1 more Smart Citation

Respiratory Symptoms and Lung Functional Impairments Associated with Occupational Exposure to Asphalt Fumes

Neghab¹,

Derisi²,

Hassanzadeh³

2015

Int J Occup Environ Med

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“…This assumption is supported by similar carry-over effects in mediators of irritation induced by fumes of bitumen found in sputum and nasal lavage analysis. (46) We found evidence for genotoxic effects in form of DNA strand breaks and alkali-labile sites. There was an association of DNA strand breaks measured after the shift with urinary 1-OHP.…”

Section: Discussionmentioning

confidence: 96%

Ambient and Biological Monitoring of Exposure and Genotoxic Effects in Mastic Asphalt Workers Exposed to Fumes of Bitumen

Marczyński

Raulf‐Heimsoth

Spickenheuer

et al. 2007

Journal of Occupational and Environmental Hygiene

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Mastic asphalt workers may be exposed to polycyclic aromatic hydrocarbons (PAH) present in bitumen. We conducted a cross-shift study to determine genotoxic effects after exposure to bitumen. For this purpose, external and internal exposure of 202 mastic asphalt workers exposed to bitumen and 55 construction workers without exposure to bitumen was assessed. Exposure by inhalation to fumes of bitumen during the shift was measured by personal ambient monitoring. To assess overall exposure to bitumen (by inhalation and dermal absorption), 1-hydroxypyrene (1-OHP) and the sum of 1-, 2 + 9-,3-,4-hydroxyphenanthrene (OHPhe) were determined in pre-and postshift urine. 8- DNA adducts, DNA strand breaks and alkali-labile sites, and micronucleus frequencies were determined as biomarkers of genotoxic effects in white blood cells (WBC). Concentrations of fumes of bitumen were correlated with a moderate association with 1-OHP and OHPhe after work shift (r s = 0.25, P < 0.001 and r s = 0.36, P < 0.001). Significantly increased 8-oxodGuo adduct levels were observed after shift in both exposure groups (P < 0.0001). Paradoxically, decreased DNA strand break frequencies were observed after shift in both groups (P < 0.05). Postshift values in DNA strand break frequency were associated with 1-OHP (Spearman rank correlation coefficient 0.19, P = 0.01). Significantly more 8-oxodGuo adducts and DNA strand breaks were found in workers exposed to bitumen before and after shift compared with the reference group. However, no dose-dependent association was observed between exposure and genotoxic effects. Nevertheless, the findings indicate that workers exposed to bitumen exerted a higher level of DNA damage (8-oxodGuo and DNA strand breaks) in WBC compared with reference subjects.

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“…The detailed study design is described elsewhere. (13) For this part of the study each worker provided a sample of spot urine and 10 ml of whole blood before and after the working shift. A structured questionnaire was applied in a face-to-face interview to assess demographic characteristics, smoking habits, and other information such as work-related health complaints.…”

Section: Study Populationmentioning

confidence: 99%

Determination of Sequence Variants of Metabolizing Enzymes After Occupational Exposure to Fumes of Bitumen Under High Processing Temperatures

Rihs

Raulf‐Heimsoth

Spickenheuer

et al. 2007

Journal of Occupational and Environmental Hygiene

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Data concerning the influence of sequence variants of metabolizing enzymes on the effect modulation of current exposure to fumes of bitumen in humans are limited. To assess effect modulation of genetic variants of metabolizing enzymes, 18 single nucleotide polymorphisms (SNPs) in metabolic enzymes were analyzed regarding their impact on the urinary levels of metabolites of polycyclic aromatic hydrocarbons. Based on personal ambient monitoring data for bitumen emissions a group of 180 workers exposed to fumes of bitumen under high processing temperatures during a shift were divided into two exposure groups: 24 with high exposure (>10 mg/m 3 ) and 156 with low (≤10 mg/m 3 ) exposure. Additionally, 55 roadside construction workers without exposure to bitumen but with similar working tasks served as a reference group. SNP determination was performed by real-time PCR using the LightCycler technology based on DNA aliquots from blood samples.The impact of sequence variants on the urinary levels of 1-OH pyrene (1-OHP) and sum of OH-phenanthrenes (OHPhe) was estimated with mixed linear models, adjusted for exposure, smoking, and other factors. Bitumen exposure was a significant predictor of the urinary concentrations of 1-OHP and OHPhe. Both metabolite levels were modulated by the GG variant of the cytochrome P450 SNP CYP3A4 −392A > G, which showed increased levels of 1-OHP (p = 0.013) and OHPhe (p = 0.001). The GG variant of EPHX1 15543A > G showed a significant effect (p = 0.006) only on OHPhe. Selected variants of metabolic enzymes can modulate the metabolite levels under exposure to bitumen. The SNP-related modulation of these biomarkers did not exceed a factor of two and is more pronounced for OHPhe than for 1-OHP.

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Irritative effects of fumes and aerosols of bitumen on the airways: results of a cross-shift study

Cited by 33 publications

References 22 publications

Respiratory Symptoms and Lung Functional Impairments Associated with Occupational Exposure to Asphalt Fumes

Respiratory Symptoms and Lung Functional Impairments Associated with Occupational Exposure to Asphalt Fumes

Ambient and Biological Monitoring of Exposure and Genotoxic Effects in Mastic Asphalt Workers Exposed to Fumes of Bitumen

Determination of Sequence Variants of Metabolizing Enzymes After Occupational Exposure to Fumes of Bitumen Under High Processing Temperatures

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