Irregular delay of adjuvant chemotherapy correlated with poor outcome in stage II-III colorectal cancer

Chen, Yuanyuan; Xu, Mingyue; Ye, Qianwen; Xiang, Jia; Xue, Tianhui; Yang, Tao; Liu, Long; Yan, Bing

doi:10.1186/s12885-022-09767-y

Cited by 6 publications

(4 citation statements)

References 56 publications

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“…For patients with lymph node-negative CRC and preoperative CEA levels > 10 ng/ml, intensive follow-up or adjuvant chemotherapy is advisable ( 17 ). Adjuvant chemotherapy (ACT) is critical in enhancing survival rates post-radical surgery for patients with stage II-III CRC ( 18 ). In stage III colorectal cancer, the incidence of perineural invasion (PNI) can reach up to 30%, marking PNI as an independent predictor of poor prognosis and decreased survival ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

“…For patients with lymph nodenegative CRC and preoperative CEA levels > 10 ng/ml, intensive follow-up or adjuvant chemotherapy is advisable (17). Adjuvant chemotherapy (ACT) is critical in enhancing survival rates postradical surgery for patients with stage II-III CRC (18). In stage III The decision curve analysis (DCA) curves and clinical impact curve (CIC) curves of nomogram for treatment failure, the nomograms (red line) had a better clinical net value than the TNM staging system (green line).…”

Section: Discussionmentioning

confidence: 99%

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Predicting treatment failure in stage III colon cancer patients after radical surgery

Zeng,

Zhong,

Liu

et al. 2024

Front. Oncol.

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PurposeThe aim to assess treatment failure in patients with stage III colon cancer who underwent radical surgery and was analyzed using the nomogram.MethodsClinical factors and survival outcomes for stage III colon cancer patients registered in the SEER database from 2018 to 2019 were analyzed, with patients split into training and testing cohorts (7:3 ratio). A total of 360 patients from the First Affiliated Hospital of Longyan served as an external validation cohort. Independent predictors of treatment failure were identified using logistic regression analyses. The nomograms was evaluated by concordance index (C-index), calibration curves, and the area under the curve (AUC), decision curve analysis (DCA) and clinical impact curves (CIC) assessed the clinical utility of nomograms versus TNM staging.ResultsThe study included 4,115 patients with stage III colon cancer. Multivariate logistic analysis age, tumor site, pT stage, pN stage, chemotherapy, pretreatment CEA levels, number of harvested lymph nodes, perineural invasion and marital status were identified as independent risk factors for treatment failure. The C-indices for the training and testing sets were 0.853 and 0.841. Validation by ROC and calibration curves confirmed the stability and reliability of the model. DCA showed that the net clinical effect of the histogram was superior to that of the TNM staging system, while CIC highlighted the potentially large clinical impact of the model.ConclusionsThe developed Nomogram provides a powerful and accurate tool for clinicians to assess the risk of treatment failure after radical surgery in patients with stage III colon cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Predicting treatment failure in stage III colon cancer patients after radical surgery

Zeng,

Zhong,

Liu

et al. 2024

Front. Oncol.

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show abstract

“…For patients with lymph node-negative CRC and preoperative CEA levels > 10 ng/ml, intensive follow-up or adjuvant chemotherapy is advisable [18] . Adjuvant chemotherapy (ACT) is critical in enhancing survival rates post-radical surgery for patients with stage II-III CRC [19] . In stage III colorectal cancer, the incidence of perineural invasion (PNI) can reach up to 30%, marking PNI as an independent predictor of poor prognosis and decreased survival [20] .…”

Section: Discussionmentioning

confidence: 99%

Predicting Treatment Failure in Stage III Colon Cancer Patients After radical surgery: A Retrospective Study

Zeng,

Zhong,

Liang

et al. 2024

Preprint

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Purpose The aim to assess treatment failure in patients with stage III colon cancer who underwent radical surgery and was analysed using the nomogram. Methods Clinical factors and survival outcomes for stage III colon cancer patients registered in the SEER database from 2018 to 2019 were analyzed, with patients split into training and testing cohorts (7:3 ratio). A total of 360 patients from the First Affiliated Hospital of Longyan served as an external validation cohort. Independent predictors of treatment failure were identified using logistic regression analyses. The nomograms was evaluated by concordance index (C-index), calibration curves, and the area under the curve (AUC), decision curve analysis (DCA) and clinical impact curves (CIC) assessed the clinical utility of nomograms versus TNM staging. Results The study included 4,115 patients with stage III colon cancer. Multivariate logistic analysis age, tumor site, pT stage, pN stage, chemotherapy, pretreatment CEA levels, number of harvested lymph nodes, perineural invasion and marital status were identified as independent risk factors for treatment failure. The C-indices for the training and testing sets were 0.853 and 0.841. Validation by ROC and calibration curves confirmed the stability and reliability of the model. DCA showed that the net clinical effect of the histogram was superior to that of the TNM staging system, while CIC highlighted the potentially large clinical impact of the model. Conclusions The developed Nomogram provides a powerful and accurate tool for clinicians to assess the risk of treatment failure after radical surgery in patients with stage III colon cancer.

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“…Disease-free survival (DFS) and OS are the primary endpoints [ 20 ]. Patients were classified into subgroups of low cDDD (< 7.72) vs. high cDDD (≥ 7.72) and ≤ 4 categories vs. >4 categories subgroups.…”

Section: Methodsmentioning

confidence: 99%

Antibiotic use during radical surgery in stage I-III colorectal cancer: correlation with outcomes?

Xu,

Chen,

et al. 2024

BMC Cancer

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Aims Accumulating evidence indicates that the use of antibiotics (ATBs) in cancer patients is potentially correlated with patient prognosis. Interestingly, the use of these agents is not uncommon in colorectal cancer (CRC) patients during surgery; however, their prognostic value in the clinic has never been addressed. Materials and methods Data on ATB use during surgery, including the cumulative defined daily dose (cDDD) and the number of categories, were collected. Differences in the clinical data between the low and high cDDD subgroups and between subgroups with ≤ 4 and >4 categories. Additionally, the disease-free survival (DFS) and overall survival (OS) among these subgroups and the specific categories were compared. Finally, a Cox proportional hazard model was used to validate the risk factors for the outcome. Results The number of categories, rather than the cDDD, was a significant predictor of both DFS (P = 0.043) and OS (P = 0.039). Patients with obstruction are more likely to have a high cDDD, whereas older patients are more likely to have multiple categories. There were no significant differences in the DFS (log rank = 1.36, P = 0.244) or OS (log rank = 0.40, P = 0.528) between patients in the low- and high-cDDD subgroups, whereas patients with ≤ 4 categories had superior DFS (log rank = 9.92, P = 0.002) and OS (log rank = 8.30, P = 0.004) compared with those with >4 categories. Specifically, the use of quinolones was harmful to survival (DFS: log rank = 3.67, P = 0.055; OS: log rank = 5.10, P = 0.024), whereas the use of macrolides was beneficial to survival (DFS: log rank = 12.26, P < 0.001; OS: log rank = 9.77, P = 0.002). Finally, the number of categories was identified as an independent risk factor for both DFS (HR = 2.05, 95% CI: 1.35–3.11, P = 0.001) and OS (HR = 1.82, 95% CI: 1.14–2.90, P = 0.012). Conclusions The cDDD of ATBs during surgery in stage I-III CRC patients did not correlate with outcome; however, patients in multiple categories or a specific category are likely to have inferior survival. These results suggest that particular caution should be taken when selecting ATBs for these patients in the clinic.

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Irregular delay of adjuvant chemotherapy correlated with poor outcome in stage II-III colorectal cancer

Cited by 6 publications

References 56 publications

Predicting treatment failure in stage III colon cancer patients after radical surgery

Predicting treatment failure in stage III colon cancer patients after radical surgery

Predicting Treatment Failure in Stage III Colon Cancer Patients After radical surgery: A Retrospective Study

Antibiotic use during radical surgery in stage I-III colorectal cancer: correlation with outcomes?

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