Iron, Zinc, Copper, Cadmium, Mercury, and Bone Tissue

Ciosek, Żaneta; Kot, Karolina; Rotter, Iwona

doi:10.3390/ijerph20032197

Cited by 29 publications

(12 citation statements)

References 198 publications

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“…Zn can stimulate runt-related transcription factor 2 (Runx2) and promote osteoblast differentiation (Fu et al, 2018). On the other hand, excess zinc induces osteoclast apoptosis (Ciosek et al, 2023). In our study, zinc played a protective role in osteopenia, but the protective factor was not signi cant in the osteoporosis stage.…”

Section: Discussionmentioning

confidence: 49%

Metal mixture exposure and the risk of osteopenia or osteoporosis: Baseline Data from the Chinese Multi-Ethnic Cohort (CMEC) Study

zhang,

Chen,

et al. 2023

Preprint

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Osteoporosis is emerging as a growing public health concern worldwide due to the aging population, and metal exposure is widely recognized as a risk factor for human health. However, studies on the relationship between metal exposure and bone health yield inconsistent results. Limited epidemiological research exists on the associations of metal mixtures with osteopenia and osteoporosis, particularly among ethnic minorities in China. We conducted a study on 9206 ethnic Chinese (Dong and Miao) aged 30–79 years using data from the Chinese Multi-Ethnic Cohort Study (CMCS) baseline survey database. We utilized inductively coupled plasma mass spectrometry (ICP-MS) to measure the concentrations of 11 metals in urine and quantitative ultrasound to measure bone mineral density (BMD). Multivariate logistic regression model, Quantile g-computation and Principal component analysis were used to explore the correlation between single-metal exposure and metal mixture exposure with osteopenia and osteoporosis. In the single-metal exposure model, urinary concentrations of As, Cd, Cr, Fe, Hg and Mn were positively associated with the risk of osteopenia. Conversely, urinary Co and Zn were negatively associated with the risk of osteopenia. Urinary As, Cd, Cr and Mn were positively associated with the risk of osteoporosis, while urinary V was negatively associated with the risk of osteoporosis. In addition, Quantile g-comptation showed that exposure to metal mixtures was positively associated with osteopenia and osteoporosis. Principal component analysis identified principal component 1, characterized by Fe and Mn, and principal component 3, characterized by Hg and Cd, as positively associated with osteopenia and osteoporosis. These findings suggest that the co-exposure of polymetals affects the occurrence and development of osteoporosis, warranting further investigation into the complex mechanisms involved.

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Section: Discussionmentioning

confidence: 49%

Metal mixture exposure and the risk of osteopenia or osteoporosis: Baseline Data from the Chinese Multi-Ethnic Cohort (CMEC) Study

zhang,

Chen,

et al. 2023

Preprint

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“…•− ) [152], and cytochrome c oxidase (Cox), involved in the mitochondrial respiratory chain [153]. Cu 2+ ions also regulate bone metabolism and accelerate the rate of wound healing, showing similar effects to those observed for Zn 2+ [5]. In addition, Cu is a proangiogenic and antibacterial agent [154].…”

Section: Coppermentioning

confidence: 83%

“…Trace metals, such as copper (Cu) and zinc (Zn), are essential for skeleton health and regeneration [4]. Bone and cartilage are influenced by Zn 2+ and Cu 2+ ions that regulate the tissues' formation, metabolism, and homeostasis under physiological conditions [5][6][7]. Changes to the normal trace metal levels can alter bone turnover, increasing the risk of fractures.…”

Section: Introductionmentioning

confidence: 99%

Carnosine, Zinc and Copper: A Menage a Trois in Bone and Cartilage Protection

Ciaffaglione,

Rizzarelli

2023

IJMS

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Dysregulated metal homeostasis is associated with many pathological conditions, including arthritic diseases. Osteoarthritis and rheumatoid arthritis are the two most prevalent disorders that damage the joints and lead to cartilage and bone destruction. Recent studies show that the levels of zinc (Zn) and copper (Cu) are generally altered in the serum of arthritis patients. Therefore, metal dyshomeostasis may reflect the contribution of these trace elements to the disease’s pathogenesis and manifestations, suggesting their potential for prognosis and treatment. Carnosine (Car) also emerged as a biomarker in arthritis and exerts protective and osteogenic effects in arthritic joints. Notably, its zinc(II) complex, polaprezinc, has been recently proposed as a drug-repurposing candidate for bone fracture healing. On these bases, this review article aims to provide an overview of the beneficial roles of Cu and Zn in bone and cartilage health and their potential application in tissue engineering. The effects of Car and polaprezinc in promoting cartilage and bone regeneration are also discussed. We hypothesize that polaprezinc could exchange Zn for Cu, present in the culture media, due to its higher sequestering ability towards Cu. However, future studies should unveil the potential contribution of Cu in the beneficial effects of polaprezinc.

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“…Many studies show zinc can stimulate bone formation and mineralization, interact with vial hormones for bone growth, and improve osteoblast differentiation [66]. Zinc also promotes the genes for bone markers [88] such as alkaline phosphatase, collagen type I, osteocalcin, and osteopontin [66]. In comparison, the zinc cation is unique because it has an apparent inhibitory effect on osteoclastic bone resorption at a concentration as low as 10-14 M [89][90].…”

Section: Copper and Zinc For Anti-chemoresistance In Osteosarcoma The...mentioning

confidence: 99%

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Zaidi¹,

Miskon²

2023

Preprint

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Due to its built-up chemoresistance after prolonged usage, the demand for replacing platinum in metal-based drugs (MBD) is rising. The first MBD approved by the FDA for cancer therapy was cisplatin in 1978. Even after nearly four and a half decades of trials, there has been no significant improvement in osteosarcoma (OS) therapy. In fact, many MBD have been developed, but the chemoresistance problem raised by platinum remains unresolved. This motivates us to elucidate the possibilities of the copper and zinc (CuZn) combination to replace platinum in MBD. Thus, the anti-chemoresistance properties of CuZn and their physiological functions for OS therapy are highlighted. Herein, we summarise their chelators, main organic solvents, and ligand functions in their structures that are involved in anti-chemoresistance properties. Through this review, it is rational to discuss their ligands’ roles as biosensors in drug delivery systems. Hereafter, an in-depth understanding of their redox and photoactive function relationships is provided. The disadvantage is that the other functions of biosensors cannot be elaborated on here. As a result, this review is being developed, which is expected to intensify OS drugs with higher cure rates. Nonetheless, this advancement intends to solve the major chemoresistance obstacle towards clinical efficacy.

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Iron, Zinc, Copper, Cadmium, Mercury, and Bone Tissue

Cited by 29 publications

References 198 publications

Metal mixture exposure and the risk of osteopenia or osteoporosis: Baseline Data from the Chinese Multi-Ethnic Cohort (CMEC) Study

Metal mixture exposure and the risk of osteopenia or osteoporosis: Baseline Data from the Chinese Multi-Ethnic Cohort (CMEC) Study

Carnosine, Zinc and Copper: A Menage a Trois in Bone and Cartilage Protection

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

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