Iron with folic acid supplemenation and birth weight in Ethiopia: Systemic review and meta-analysis

Abstract

The aim of this systemic review and meta-analysis was to examine the relationship between iron with folic acid supplementation and low birth weight in Ethiopia Previous studies on iron with folic acid supplementation and low birth weight indicated different findings. We include 24 studies in different regions of Ethiopia. We have done this study focusing on iron with folic acid supplementation Materials and Methods The databases searched were PUBMED and Advanced Google Scholar. on reference manager software reporting iron with folic acid supplementation and low birth weight. Three researchers were carried out the data extraction and assessed independently the articles for inclusion in the review using risk-of-bias tool guided by PRISMA checklist. The combined adjusted Odds ratios (OR)) and 95% confidence intervals were calculated using random effect model Results: Twenty-four observational studies involving 10 989 participants, 2348 newborns have low birth weight were included. The combined effect size (OR) for low birth weight r comparing women who have iron with folic acid supplementation versus women who did not have iron with folic acid supplementation was 0.37 (95%CI 0.25 to 0.55), p<0.00001, I 2 = 91 %). There was significant heterogeneity (Q = 264.75. I 2 =91 %). p<0.00001) No publication bias was observed (Egger's test: p = 0.621, Begg's test: p = 0.254). 71.11% (7815), women reported iron with folic acid supplementation during current pregnancy in all studies, the proportion of low birth weight among women reported iron with folic acid supplementation during current

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