Iron prophylaxis during pregnancy – How much iron is needed? A randomized dose– response study of 20–80 mg ferrous iron daily in pregnant women

Milman, Nils; Bergholt, Thomas; Eriksen, Lisbeth; Byg, Keld-Erik; Graudal, Niels; Pedersen, Palle; Hertz, J. B.

doi:10.1111/j.0001-6349.2005.00610.x

Cited by 102 publications

(99 citation statements)

References 36 publications

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“…In agreement with previous studies, 1,6 we found an almost 50% decline in the concentration of cobalamins during late pregnancy (Table 1). A small increase in MMA was observed during pregnancy and post partum (Table 1) but we question whether this is caused by an increased metabolic rate during pregnancy and lactation rather than a sign of vitamin B12 deficiency.…”

supporting

confidence: 93%

Holotranscobalamin remains unchanged during pregnancy. Longitudinal changes of cobalamins and their binding proteins during pregnancy and postpartum

Mørkbak¹,

Hvas²,

Milman³

et al. 2007

Haematologica

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We confirm a decrease in cobalamins during pregnancy, and report that the active part of cobalamins (holotranscobalamin, holoTC) remains unchanged. The decrease in cobalamins is explained by a decreased holohaptocorrin (holoHC), suggesting that holoTC rather than cobalamins should be used as a marker of vitamin B12 deficiency during pregnancy. Haematologica 2007; 92:1711 92: -1712 We studied the interrelations between cobalamins, TC and HC (holo and total) during pregnancy in a follow-up study of pregnant women previously described in detail.

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supporting

confidence: 93%

Holotranscobalamin remains unchanged during pregnancy. Longitudinal changes of cobalamins and their binding proteins during pregnancy and postpartum

Mørkbak¹,

Hvas²,

Milman³

et al. 2007

Haematologica

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“…4 A study of Danish pregnant women which evaluated the effect of 20, 40, 60, and 80 mg of iron daily found 20 mg was inadequate to prevent ID in a substantial number of women and that 40 mg of iron prevented IDA in more than 95% of the women. 19 Our findings reveal a high prevalence of women taking popular pregnancy MVs, with most containing only 5 mg of elemental iron per tablet. Furthermore, it appears many women may not take the recommended number of tablets on a daily basis.…”

Section: Discussionmentioning

confidence: 69%

Iron supplement use in pregnancy – Are the right women taking the right amount?

et al. 2016

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“…On the other hand, in a randomised controlled trial with iron supplements in varying doses, no difference in occurrence of side-effects was reported in the groups who received 20, 40, 60 or 80 mg iron per day 42 . However, this may be a reason for not taking iron supplements, as many of the available products contain 100 mg iron per daily dosage.…”

Section: Discussionmentioning

confidence: 91%

Iron supplement use among Danish pregnant women

Knudsen

Hansen

Ovesen

et al. 2007

Public Health Nutr.

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Objectives: To evaluate compliance with the national recommendation on supplemental iron to all pregnant women in Denmark and to explore differences between compliers and non-compliers with respect to dietary habits and other lifestyle factors. Design: Intake of supplemental iron from pure iron supplements and from multivitamin and mineral preparations was estimated in mid-pregnancy. Setting: Nationwide cohort study, the Danish National Birth Cohort (DNBC), comprising more than 100 000 women recruited in early pregnancy. Subjects: Information on diet and dietary supplements was available for 54 371 women. Of these, information on lifestyle factors was available for 50 902 women. Results: A high compliance with the recommendation was found, as approximately 77% of the women reported use of iron supplements during pregnancy. However, many of the compliers did not obtain the recommended doses of iron, which can partly be explained by the lack of iron preparations of appropriate doses available on the Danish market. Compliance with the recommendation was associated with age above 20 years, primiparity, body mass index , 30 kg m 22 , non-smoking and long education. No major differences were seen in dietary intake between compliers and non-compliers. Conclusion: Overall, a high compliance rate was found among participants of the DNBC but a clarification on daily dose is needed, and more concern should be paid to vulnerable groups such as young, smoking women and women with no or short education.

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Iron prophylaxis during pregnancy – How much iron is needed? A randomized dose– response study of 20–80 mg ferrous iron daily in pregnant women

Abstract: In Danish women, a supplement of 40 mg ferrous iron/day from 18 weeks of gestation appears adequate to prevent iron deficiency in 90% of the women and iron deficiency anemia in at least 95% of the women during pregnancy and postpartum.

Cited by 102 publications

References 36 publications

Holotranscobalamin remains unchanged during pregnancy. Longitudinal changes of cobalamins and their binding proteins during pregnancy and postpartum

Holotranscobalamin remains unchanged during pregnancy. Longitudinal changes of cobalamins and their binding proteins during pregnancy and postpartum

Iron supplement use in pregnancy – Are the right women taking the right amount?

Iron supplement use among Danish pregnant women

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