Iron promotes ADAM-17 mediated sCD163: TNF-α liberation and modulates inflammation in severe alcoholic hepatitis

Maras, Jaswinder Singh; Das, Shyamashish; Hussain, Md. Shabir; Sukriti, Sukriti; Sharma, Sheetal; Theranpati, N.; Maiwall, Rakhi; Sarin, Shiv Kumar

doi:10.1016/s0168-8278(17)31035-8

Cited by 1 publication

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“…Tumor necrosis factor‐α is one of the most important inflammatory mediators, which can initiate and trigger inflammatory responses and cause multiple signaling cascades . IL‐6 induces adhesion and aggregation of inflammatory cells to promote inflammation, which plays diverse roles in the body .…”

Section: Discussionmentioning

confidence: 99%

“…The levels of TBIL, DBIL, and ALT in observation group were remarkably lower than those in control group, while the CHE level was remarkably higher than Tumor necrosis factor-α is one of the most important inflammatory mediators, which can initiate and trigger inflammatory responses and cause multiple signaling cascades. 16 IL-6 induces adhesion and aggregation of inflammatory cells to promote inflammation, which plays diverse roles in the body. 17 CRP represents a commonly used inflammatory index in clinic.…”

Section: Ta B L E 8 Comparisons Of T Lymphocyte Subsets Between the Tmentioning

confidence: 99%

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Effects of dual plasma molecular adsorption system on liver function, electrolytes, inflammation, and immunity in patients with chronic severe hepatitis

Gao

et al. 2019

Clinical Laboratory Analysis

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Background:To investigate the effects of dual plasma molecular adsorption system (DPMAS)ontheliverfunction,electrolytes,inflammation,andimmunityinpatients withchronicseverehepatitis(CSH). Methods: Totalof162patientswithCSHtreatedinourhospitalfromMarch2016to December 2018 were enrolled and equally randomly divided into control group (n=81)andobservationgroup(n=81).Thepatientsincontrolgroupweretreated with plasma exchange, while those in observation group were additionally treated withDPMASbasedonthetreatmentincontrolgroup.Theliverfunction,electrolytes, inflammation, and immunity were evaluated and compared between the two groups.Results: After treatment, the liver function indexes in observation group were significantly favorable compared with those in control group, with the reduction in TBIL, DBIL, ALT, and rise of CHE levels (P<0.05).ThelevelsofK + ,Na + , Cl − , and Ca 2+ in both groups were significantly improved after treatment (P<0.05),althoughtherewere no significant differences between the two groups (P>0.05).ThelevelsofC-reactiveprotein(CRP),interleukin-6(IL-6),andtumornecrosisfactor-α(TNF-α)inboth groups declined after treatment compared with those before treatment, and those levels in observation group were higher than that in control group (P<0.05).After treatment, the levels of cluster of differentiation 3 + (CD3 + ),CD4 + , and CD4 + /CD8 + were higher in observation group than those in control group, with decreasing level of CD8 + (P<0.05). Conclusion:Dual plasma molecular adsorption system can effectively improve the liver function, effectively correct the electrolyte disorders, reduce the inflammatory response, and adjust the immunity in patients with CSH. K E Y W O R D Schronic severe hepatitis, dual plasma molecular adsorption system, electrolytes, immune function, liver functionThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, providedtheoriginalworkisproperlycited.

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Section: Discussionmentioning

confidence: 99%

Section: Ta B L E 8 Comparisons Of T Lymphocyte Subsets Between the Tmentioning

confidence: 99%

Effects of dual plasma molecular adsorption system on liver function, electrolytes, inflammation, and immunity in patients with chronic severe hepatitis

Gao

et al. 2019

Clinical Laboratory Analysis

View full text Add to dashboard Cite

show abstract

Iron promotes ADAM-17 mediated sCD163: TNF-α liberation and modulates inflammation in severe alcoholic hepatitis

Cited by 1 publication

References 0 publications

Effects of dual plasma molecular adsorption system on liver function, electrolytes, inflammation, and immunity in patients with chronic severe hepatitis

Effects of dual plasma molecular adsorption system on liver function, electrolytes, inflammation, and immunity in patients with chronic severe hepatitis

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