Iron oxide nanoparticles as magnetic resonance contrast agent for tumor imaging via folate receptor-targeted delivery1

Choi, Hoon; Choi, Seok; Zhou, Rong; Kung, Hank F.; Chen, I‐Wei

doi:10.1016/j.acra.2004.04.018

Cited by 226 publications

(141 citation statements)

References 24 publications

Supporting

Mentioning

136

Contrasting

Unclassified

Order By: Relevance

“…In vivo MR imaging revealed an average T2 intensity decrease of 38% from pre-contrast to post-contrast images of the tumor. 1,24,138 Another cancer marker recently targeted with SPIO is the underglycosylated MUC-1 tumor antigen (uMUC-1). This antigen is a common feature of numerous epithelial cell adenocarcinomas including breast, pancreatic, colorectal, lung, prostate, and gastric cancers.…”

Section: Cancer Imagingmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

et al. 2006

View full text Add to dashboard Cite

Abstract-The field of molecular imaging has recently seen rapid advances in the development of novel contrast agents and the implementation of insightful approaches to monitor biological processes non-invasively. In particular, superparamagnetic iron oxide nanoparticles (SPIO) have demonstrated their utility as an important tool for enhancing magnetic resonance contrast, allowing researchers to monitor not only anatomical changes, but physiological and molecular changes as well. Applications have ranged from detecting inflammatory diseases via the accumulation of non-targeted SPIO in infiltrating macrophages to the specific identification of cell surface markers expressed on tumors. In this article, we attempt to illustrate the broad utility of SPIO in molecular imaging, including some of the recent developments, such as the transformation of SPIO into an activatable probe termed the magnetic relaxation switch.

show abstract

Section: Cancer Imagingmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

et al. 2006

View full text Add to dashboard Cite

show abstract

“…For example, magnetic nanoparticles have recently received much attention due to their potential application in clinical cancer treatment, [158][159][160][161][162] targeted drug delivery [163][164][165] and MRI contrast agents. 166,167 However, despite the useful functionalities that might derive from metal nanoparticle systems, the lack of targeting strategies has limited their application to locoregional disease. Thus, tumorselective delivery is key to improve therapeutic applications of metal nanoparticle systems, rationalizing incorporation of such particles into targeted, multifunctional Ad vectors via conjugation to capsid proteins or other means.…”

Section: Future Applicationsmentioning

confidence: 99%

Transductional targeting of adenovirus vectors for gene therapy

2006

View full text Add to dashboard Cite

“…Magnetic resonance imaging of mice bearing subcutaneous KB tumors showed that superparamagnetic iron oxide (SPIO) NPs were rapidly internalized in vivo by the tumor cells only when conjugated with folate. 53,54 Tumor-targeted drug delivery systems are currently envisioned as magic bullets for cancer therapy and several groups are working globally for development of robust International Journal of Nanomedicine 2012:7 submit your manuscript | www.dovepress.com Dovepress Dovepress systems addressing issues of specificity. A summary of a few important nanovector prototypes against typical tumor signatures is presented in Table 2.…”

Section: Folate-linked Npsmentioning

confidence: 99%

Nanomedicine: towards development of patient-friendly drug-delivery systems for oncological applications

Ranganathan¹,

Madanmohan²,

Kesavan³

et al. 2012

IJN

View full text Add to dashboard Cite

The focus on nanotechnology in cancer treatment and diagnosis has intensified due to the serious side effects caused by anticancer agents as a result of their cytotoxic actions on normal cells. This nonspecific action of chemotherapy has awakened a need for formulations capable of definitive targeting with enhanced tumor-killing. Nanooncology, the application of nanobiotechnology to the management of cancer, is currently the most important area of nanomedicine. Currently several nanomaterial-based drug-delivery systems are in vogue and several others are in various stages of development. Tumor-targeted drug-delivery systems are envisioned as magic bullets for cancer therapy and several groups are working globally for development of robust systems.

show abstract

Iron oxide nanoparticles as magnetic resonance contrast agent for tumor imaging via folate receptor-targeted delivery1

Cited by 226 publications

References 24 publications

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

Transductional targeting of adenovirus vectors for gene therapy

Nanomedicine: towards development of patient-friendly drug-delivery systems for oncological applications

Contact Info

Product

Resources

About