Iron in spleen tissues

Abstract

Macroscopic quantum tunneling in antiferromagnetic horse-spleen ferritin particles (abstract)Abstract: Mössbauer spectroscopy of iron deposits in thalassemic heart tissue Abstract. This contribution aims in characterization of structural positions of iron in human and horse spleen. 57 Fe Mössbauer spectroscopy was employed as a principal method of investigation in addition to X-ray diffraction and transmission electron microscopy (TEM). At room temperature, ferritin nanoparticles exhibit superparamagnetic behavior due to their small dimensions. Corresponding Mössbauer spectra show doublet-like patterns. Experiments performed at low temperatures unveiled presence of magnetically split components and enabled to determine the blocking temperature. Dimensions of Fe-containing species were established from detailed analyses of TEM images.

Mössbauer and SQUID Characterization of Iron in Human Tissue: Case of Globus Pallidus

“…On the other hand, SQUID magnetometry has revealed dierent magnetic states of the investigated samples. Their origin might be assigned to distribution in size and shape of the Fe nanoparticles [7] that aect also the blocking temperature [8], as we have recently determined for human and horse spleen tissues by MS. Presence of bigger paramagnetic and/or ferromagnetic iron oxide deposits outside ferritin (or its inorganic core) cannot be excluded, too.…”

Mössbauer Spectrometry Study of Biological Tissues

“…Doublet-like spectra are characteristic for a nonmagnetic material that is paramagnetic at room temperature and/or are caused by superparamagnetic behaviour of small Fe-containing particles. Presence of the latter in spleen tissues was confirmed by transmission electron microscopy [10]. Particles with similar sizes exhibit superparamagnetic behaviour as evidenced by magnetic measurements of synthesized magnetoferritin [11].…”

“…No traces of sextets were revealed. It is noteworthy that X-ray diffractograms performed upon a sample of human spleen showed featureless broadened reflections [10] that are characteristic for a XRD amorphous material. They also confirm that the structure of ferritin particles is highly disordered and/or consists of particles with very small dimensions.…”

“…They can be assigned to hematite (D1) and ferrihydrite (D2) [6]. Doublet D3 can be due to magnetite and/or maghemite [10]. In the brain sample, D2 probably represents both hematite and ferrihydrite.…”

“…We assign the individual spectral components as follows [10]: S1 -hematite, S2, S3 -ferrihydrite core and surface, respectively, S4 -magnetite and/or maghemite. The latter can be partially included also in S3 of the brain and human spleen samples.…”