Iron-Fortified vs Low-Iron Infant Formula

Abstract

Objective: To assess long-term developmental outcome in children who received iron-fortified or lowiron formula.Design: Follow-up at 10 years of a randomized controlled trial (1991)(1992)(1993)(1994) of 2 levels of formula iron. Examiners were masked to group assignment.

Association of Iron Status and Intake During Pregnancy with Neuropsychological Outcomes in Children Aged 7 Years: The Prospective Birth Cohort Infancia y Medio Ambiente (INMA) Study

“…Previous evidence suggests a higher risk for poorer neurodevelopmental outcomes in children born to mothers with SF levels >60 ug/L in the first and second trimester of gestation [27,31], exhibiting a U-shaped risk, however, in our study we have not observed this association. Specifically, we did not find substantial differences in neuropsychological outcomes in children whose mothers had SF levels from 12 to 60 µg/L and those with SF levels ≥60 µg/L.…”

Multiple Micronutrient Supplementation Using Spirulina platensis during the First 1000 Days is Positively Associated with Development in Children under Five Years: A Follow up of A Randomized Trial in Zambia

“…This result suggests that the MMN supplementation had larger effects on infants who were already disadvantaged and with higher risk of delayed motor development at enrolment. This result is consistent with those of other existing studies evaluating the effectiveness of MNP supplementation during the first 1000 days of child development in Burkina Faso, Chile, Bangladesh, and Indonesia [21,22,24,25]. In summary, this is the first study to present that the supplementation of MMN using locally producible foods, spirulina, improved motor development even after an 18-month non-intervention period.…”

Effects of iron supplementation on growth, gut microbiota, metabolomics and cognitive development of rat pups

“…This behavior aspect of memory is similar in animals and humans [32]. It is interesting to note that Lozoff et al found adverse effects on several measures of cognition, behavior and motor development in Chilean infants with adequate iron status who were given high iron infant formula [6]. These infants likely had adequate nutritional status and our results therefore suggest that this is a valid model for the human infant.…”