Iron for the treatment of restless legs syndrome

Abstract

a We downgraded one level for publication bias for several reasons: 1) one study completed in 2012 (NCT00685815) for which published results could not be found in the search; 2) generally small sample sizes; and 3) the majority of participants were in trials funded by pharmaceutical companies. b We downgraded one level for the possibility of selective outcome reporting, as this outcome was infrequently reported across studies. c We downgraded one level because the Optimal Information Size (OIS) calculation suggests insu icient power for this outcome.

Metabolomics in Central Sensitivity Syndromes

“…Finally, NMR studies suggest significantly reduced iron in multiple brain regions of RLS patients compared to healthy individuals. This finding suggests that iron may be a promising metabolite in the study, diagnosis, and treatment of RLS [197].…”

Metabolomics in Central Sensitivity Syndromes

“…Finally, NMR studies suggest significantly reduced iron in multiple brain regions of RLS patients compared to healthy individuals. This finding suggests that iron may be a promising metabolite in the study, diagnosis, and treatment of RLS [197].…”

Caffeine in Aging Brains: Cognitive Enhancement, Neurodegeneration, and Emerging Concerns About Addiction

“…Given that RLS symptoms tend to intensify during evening and nocturnal hours, sleep deprivation caused by caffeine consumption may further aggravate the disorder [ 147 ]. Iron Bioavailability: Iron deficiency is a recognized risk factor for RLS [ 148 ]. Although there is no conclusive evidence that caffeine directly impairs iron absorption, some studies suggest that high caffeine intake may interfere with intestinal iron uptake [ 149 ].…”

“…Iron Bioavailability: Iron deficiency is a recognized risk factor for RLS [ 148 ]. Although there is no conclusive evidence that caffeine directly impairs iron absorption, some studies suggest that high caffeine intake may interfere with intestinal iron uptake [ 149 ].…”

Short course of low‐dose pregabalin is effective for the treatment of restless leg syndrome in patients with cirrhosis: A pilot study

“…Symptoms of RLS completely resolved with iron supplementation alone in nearly half of those with low ferritin. A recent Cochrane review has also shown the beneficial effect of iron on RLS severity score, albeit in persons without cirrhosis 17 …”

Metabolomics in Central Sensitivity Syndromes

“…Finally, NMR studies suggest significantly reduced iron in multiple brain regions of RLS patients compared to healthy individuals. This finding suggests that iron may be a promising metabolite in the study, diagnosis, and treatment of RLS [197].…”

Caffeine in Aging Brains: Cognitive Enhancement, Neurodegeneration, and Emerging Concerns About Addiction

“…Given that RLS symptoms tend to intensify during evening and nocturnal hours, sleep deprivation caused by caffeine consumption may further aggravate the disorder [ 147 ]. Iron Bioavailability: Iron deficiency is a recognized risk factor for RLS [ 148 ]. Although there is no conclusive evidence that caffeine directly impairs iron absorption, some studies suggest that high caffeine intake may interfere with intestinal iron uptake [ 149 ].…”

“…Iron Bioavailability: Iron deficiency is a recognized risk factor for RLS [ 148 ]. Although there is no conclusive evidence that caffeine directly impairs iron absorption, some studies suggest that high caffeine intake may interfere with intestinal iron uptake [ 149 ].…”

Short course of low‐dose pregabalin is effective for the treatment of restless leg syndrome in patients with cirrhosis: A pilot study

“…Symptoms of RLS completely resolved with iron supplementation alone in nearly half of those with low ferritin. A recent Cochrane review has also shown the beneficial effect of iron on RLS severity score, albeit in persons without cirrhosis 17 …”

Metabolomics in Central Sensitivity Syndromes

“…Finally, NMR studies suggest significantly reduced iron in multiple brain regions of RLS patients compared to healthy individuals. This finding suggests that iron may be a promising metabolite in the study, diagnosis, and treatment of RLS [197].…”

Caffeine in Aging Brains: Cognitive Enhancement, Neurodegeneration, and Emerging Concerns About Addiction

“…Given that RLS symptoms tend to intensify during evening and nocturnal hours, sleep deprivation caused by caffeine consumption may further aggravate the disorder [ 147 ]. Iron Bioavailability: Iron deficiency is a recognized risk factor for RLS [ 148 ]. Although there is no conclusive evidence that caffeine directly impairs iron absorption, some studies suggest that high caffeine intake may interfere with intestinal iron uptake [ 149 ].…”

“…Iron Bioavailability: Iron deficiency is a recognized risk factor for RLS [ 148 ]. Although there is no conclusive evidence that caffeine directly impairs iron absorption, some studies suggest that high caffeine intake may interfere with intestinal iron uptake [ 149 ].…”

Short course of low‐dose pregabalin is effective for the treatment of restless leg syndrome in patients with cirrhosis: A pilot study

“…Symptoms of RLS completely resolved with iron supplementation alone in nearly half of those with low ferritin. A recent Cochrane review has also shown the beneficial effect of iron on RLS severity score, albeit in persons without cirrhosis 17 …”