Iron Chelation in Local Infection

Scott, Cassidy; Arora, Gaurav; Dickson, Kayle; Lehmann, Christian

doi:10.3390/molecules26010189

Cited by 25 publications

(26 citation statements)

References 90 publications

(70 reference statements)

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“…Deferrioxamine, a drug that has shown the ability to disrupt biofilms integrity ( Ishida et al, 2011 ), was found to have proprieties similar to IP6, where both have significant iron-chelating properties ( Hawkins et al, 1993 ). Studies have shown that iron-chelating agents are effective against pathogenic organisms ( Coraça-Huber et al, 2018 ; Scott et al, 2021 ), presumably because iron is an important component for bacterial proliferation and biofilm formation ( Lin et al, 2012 ; Farrand et al, 2015 ). Hence, it is plausible to speculate that iron-chelation by IP6 might play a role in its broad-spectrum antibacterial and antibiofilm activity reported in this study.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity of Phytic Acid: An Emerging Agent in Endodontics

Nassar

Vianna

et al. 2021

Front. Cell. Infect. Microbiol.

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BackgroundPhytic acid (IP6) is a promising and emerging agent, and because of its unique structure and distinctive properties, it lends itself to several applications in dentistry. Recently, IP6 was proposed as a potential chelating agent in endodontics. However, there is limited knowledge regarding its antimicrobial and antibiofilm effectiveness. The aims of this study, were therefore to evaluate the antimicrobial and antibiofilm activities of IP6 against a range of microbial species and compare these with ethylenediaminetetraacetic acid (EDTA) and sodium hypochlorite (NaOCl). The contact time required for IP6 to exert its bactericidal effect on Enterococcus faecalis was also determined.MethodsThe inhibitory and biocidal activities of IP6, EDTA and NaOCl were assessed using a broth microdilution assay against 11 clinical and reference strains of bacteria and a reference strain of Candida albicans. The contact time required for various IP6 concentrations to eliminate planktonic cultures of E. faecalis was determined using a membrane filtration method according to BS-EN-1040:2005. IP6 bactericidal activity was also evaluated using fluorescent microscopy, and the antibiofilm activity of the test agents was also determined.ResultsIP6 was biocidal against all tested microorganisms. At concentrations of 0.5%, 1% and 2%, IP6 required 5 min to exert a bactericidal effect on E. faecalis, while 5% IP6 was bactericidal after 30 s. IP6 also eradicated biofilms of the tested microorganisms. In conclusion, IP6 had notable antimicrobial effects on planktonic and biofilm cultures and exhibited rapid bactericidal effects on E. faecalis. This research highlighted, for the first time the antimicrobial and antibiofilm properties of IP6, which could be exploited, not only in dental applications, but also other fields where novel strategies to counter antimicrobial resistance are required.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity of Phytic Acid: An Emerging Agent in Endodontics

Nassar

Vianna

et al. 2021

Front. Cell. Infect. Microbiol.

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“…Iron chelators have higher affinity constants for iron and therefore, prevent the accumulation of excess iron and challenge the fungal growth with the iron-depleting environment (Symeonidis 2009 ). Food and drug administration (FDA) approved iron chelators include oral tablets such as Deferiprone (DFP), Deferasirox (DFX), and injectable Desferrioxamine (DFO) (Scott et al 2021 ). DFO received FDA approval for treating iron overload in transfusion-dependent anemia in the year 2005.…”

Section: Management Of Mucormycosismentioning

confidence: 99%

COVID-19 associated mucormycosis: evolving technologies for early and rapid diagnosis

Samson

Dharne

2021

3 Biotech

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The post-coronavirus disease (COVID-19) mucormycosis is a deadly addition to the pandemic spectrum. Although it’s a rare, aggressive, and opportunistic disease, the associated morbidity and mortality are significant. The complex interplay of factors aggravating CAM is uncontrolled diabetes, irrational and excessive use of antibiotics, steroids, and an impaired immune system. Recently, India has been witnessing a rapid surge in the cases of coronavirus disease-associated mucormycosis (CAM), since the second wave of COVID-19. The devastating and lethal implications of CAM had now become a matter of global attention. A delayed diagnosis is often associated with a poor prognosis. Therefore, the rapid and early diagnosis of infection would be life-saving. Prevention and effective management of mucormycosis depend upon its early and accurate diagnosis followed by a multimodal therapeutic approach. The current review summarizes an array of detection methods and highlights certain evolving technologies for early and rapid diagnosis of CAM. Furthermore, several potential management strategies have also been discussed, which would aid in tackling the neglected yet fatal crisis of mucormycosis associated with COVID-19.

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“…This suggests that preventing metal acquisition by fungal pathogens through metal chelation is an alternative approach to copy with fungal infections. Iron is the most abundant trace metal and an essential nutrient for eukaryotic cells ( 7 , 8 ). Because of its redox properties, it plays a pivotal role in many core metabolic pathways, such as cell respiration, electron transport chains, iron-sulfur cluster assembly, and oxygen transfer ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

Selective Metal Chelation by a Thiosemicarbazone Derivative Interferes with Mitochondrial Respiration and Ribosome Biogenesis in Candida albicans

Duan

Xie

et al. 2022

Microbiol Spectr

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The increasing incidence of fungal infections and resistance to existing antifungals call for the development of broad-spectrum antifungals with novel mechanisms of action. In this study, we demonstrate that a thiosemicarbazone derivative 19ak selectively inhibits mitochondrial respiration mainly by retarding mitochondrial respiratory chain complex I activity through iron chelation and inhibits ribosome biogenesis mainly by disrupting intracellular zinc homeostasis in C. albicans .

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Iron Chelation in Local Infection

Cited by 25 publications

References 90 publications

Antimicrobial Activity of Phytic Acid: An Emerging Agent in Endodontics

Antimicrobial Activity of Phytic Acid: An Emerging Agent in Endodontics

COVID-19 associated mucormycosis: evolving technologies for early and rapid diagnosis

Selective Metal Chelation by a Thiosemicarbazone Derivative Interferes with Mitochondrial Respiration and Ribosome Biogenesis in Candida albicans

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