Iron-Based Hollow Nanoplatforms for Cancer Imaging and Theranostics

Luo, Siyi; Qin, Shuijie; Oudeng, Gerile; Zhang, L.

doi:10.3390/nano12173023

Cited by 3 publications

(2 citation statements)

References 127 publications

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“…When combined with other small molecules (such as photosensitizers, fluorescent dyes, chemotherapeutic medicines, etc. ), iron ions can be employed as therapeutic agents for the Fenton reaction, photothermal therapy, and magnetic thermotherapy (MTH) [118]. As mentioned above, Fe 3+ in the human body can be absorbed by transferrin, released in an acidic environment, and then reduced to Fe 2+ .…”

Section: Iron-based Nanoparticlesmentioning

confidence: 99%

Photodynamic Therapy Combined with Ferroptosis Is a Synergistic Antitumor Therapy Strategy

Huang,

Li,

Zhang

et al. 2023

Cancers

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Ferroptosis is a programmed death mode that regulates redox homeostasis in cells, and recent studies suggest that it is a promising mode of tumor cell death. Ferroptosis is regulated by iron metabolism, lipid metabolism, and intracellular reducing substances, which is the mechanism basis of its combination with photodynamic therapy (PDT). PDT generates reactive oxygen species (ROS) and 1O2 through type I and type II photochemical reactions, and subsequently induces ferroptosis through the Fenton reaction and the peroxidation of cell membrane lipids. PDT kills tumor cells by generating excessive cytotoxic ROS. Due to the limited laser depth and photosensitizer enrichment, the systemic treatment effect of PDT is not good. Combining PDT with ferroptosis can compensate for these shortcomings. Nanoparticles constructed by photosensitizers and ferroptosis agonists are widely used in the field of combination therapy, and their targeting and biological safety can be improved through modification. These nanoparticles not only directly kill tumor cells but also further exert the synergistic effect of PDT and ferroptosis by activating antitumor immunity, improving the hypoxia microenvironment, and inhibiting the tumor angiogenesis. Ferroptosis-agonist-induced chemotherapy and PDT-induced ablation also have good clinical application prospects. In this review, we summarize the current research progress on PDT and ferroptosis and how PDT and ferroptosis promote each other.

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Section: Iron-based Nanoparticlesmentioning

confidence: 99%

Photodynamic Therapy Combined with Ferroptosis Is a Synergistic Antitumor Therapy Strategy

Huang,

Li,

Zhang

et al. 2023

Cancers

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“…In this Special Issue, there are research articles that focus on the use of nanomaterials for quantum technology applications [1][2][3][4][5][6][7], nanomaterials for health science [8][9][10] and nanomaterials for solar cells [11].…”

Section: Acknowledgmentsmentioning

confidence: 99%

Advanced Nanomaterials for Quantum Technology, Sensor and Health Therapy Applications

Baskoutas

2023

Nanomaterials

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Naphtho[1,8‐ef]isoindole‐7,8,10(9H)‐trione as Novel Theranostic Agents for Photodynamic Therapy and Multi‐Subcellular Organelles Localization

Tan,

Fu,

Lei

et al. 2024

ChemMedChem

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A series of naphtho[1,8‐ef]isoindole‐7,8,10(9H)‐trione as novel theranostic agents for photodynamic therapy and multi‐subcellular organelles localization were designed and synthesized. Most of them possess moderate fluorescence quantum yield and long wavelength absorption simultaneously, these made them possible for dual effects of imaging and therapy. Especially, 7b and 7d exhibited significant light‐toxicity but slight dark‐toxicity. Confocal fluorescence microscopy experiments demonstrated that 7b can locate and image in special multi‐subcellular organelles. All the research results implied that carbonyl‐phenalene‐2,3‐dicarboximides derivatives can be applied as a new series of theranostic agents with the characteristics of photodynamic therapy and multi‐subcellular organelles imaging.

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Iron-Based Hollow Nanoplatforms for Cancer Imaging and Theranostics

Cited by 3 publications

References 127 publications

Photodynamic Therapy Combined with Ferroptosis Is a Synergistic Antitumor Therapy Strategy

Photodynamic Therapy Combined with Ferroptosis Is a Synergistic Antitumor Therapy Strategy

Advanced Nanomaterials for Quantum Technology, Sensor and Health Therapy Applications

Naphtho[1,8‐ef]isoindole‐7,8,10(9H)‐trione as Novel Theranostic Agents for Photodynamic Therapy and Multi‐Subcellular Organelles Localization

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