Iron and oxidizing species in oxidative stress and Alzheimer's disease

Zhao, Zhongwei

doi:10.1002/agm2.12074

Cited by 81 publications

(53 citation statements)

References 52 publications

(160 reference statements)

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“…One of the reasons is the causation of oxidative stress. All metal ions used in the study are transition metals, which can catalyze Fenton and Haber-Weiss reactions, resulting in ROS formation, such as superoxide anions (•O − 2 ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals (•OH) [45]. Each organism (cell) contains various antioxidant defense systems, including SOD and CAT, which are two enzymes that provide a defense grid for removing ROS [46].…”

Section: Discussionmentioning

confidence: 99%

Are Metal Ions That Make up Orthodontic Alloys Cytotoxic, and Do They Induce Oxidative Stress in a Yeast Cell Model?

Kovač

Poljšak

Primožič

et al. 2020

IJMS

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Compositions of stainless steel, nickel-titanium, cobalt-chromium and β-titanium orthodontic alloys were simulated with mixtures of Fe, Ni, Cr, Co, Ti and Mo metal ions as potential oxidative stress-triggering agents. Wild-type yeast Saccharomyces cerevisiae and two mutants ΔSod1 and ΔCtt1 were used as model organisms to assess the cytotoxicity and oxidative stress occurrence. Metal mixtures at concentrations of 1, 10, 100 and 1000 µM were prepared out of metal chlorides and used to treat yeast cells for 24 h. Every simulated orthodontic alloy at 1000 µM was cytotoxic, and, in the case of cobalt-chromium alloy, even 100 µM was cytotoxic. Reactive oxygen species and oxidative damage were detected for stainless steel and both cobalt-chromium alloys at 1000 µM in wild-type yeast and 100 µM in the ΔSod1 and ΔCtt1 mutants. Simulated nickel-titanium and β-titanium alloy did not induce oxidative stress in any of the tested strains.

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Section: Discussionmentioning

confidence: 99%

Are Metal Ions That Make up Orthodontic Alloys Cytotoxic, and Do They Induce Oxidative Stress in a Yeast Cell Model?

Kovač

Poljšak

Primožič

et al. 2020

IJMS

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“…However, it is for sure that aging is the major risk factor for age-related iron accumulation and neurodegeneration [13]. Iron seems to promote both deposition of amyloid-β protein and oxidative stress, which is associated with the plaques [7,253]. In contrast, some argued that, by binding iron, Aβ-protein might protect the surrounding neurons from oxidative stress [254].…”

Section: Iron and Alzheimer's Diseasementioning

confidence: 99%

“…The body absorbs 1-2 mg of dietary iron a day, and this intake must be balanced with losses in the form of sloughed intestinal mucosal cells, menstruation, and other blood losses [5]. Maintaining the balance is very important because free iron is able to generate free radicals through Fenton reaction, and it is highly toxic [6,7]. Therefore, organisms have developed sophisticated pathways to import, chaperone, sequester, and export iron in order to maintain an appropriate iron balance [8].…”

Section: Introductionmentioning

confidence: 99%

Age-Related Changes and Sex-Related Differences in Brain Iron Metabolism

Kezele

Ćurko-Cofek

2020

Nutrients

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Iron is an essential element that participates in numerous cellular processes. Any disruption of iron homeostasis leads to either iron deficiency or iron overload, which can be detrimental for humans’ health, especially in elderly. Each of these changes contributes to the faster development of many neurological disorders or stimulates progression of already present diseases. Age-related cellular and molecular alterations in iron metabolism can also lead to iron dyshomeostasis and deposition. Iron deposits can contribute to the development of inflammation, abnormal protein aggregation, and degeneration in the central nervous system (CNS), leading to the progressive decline in cognitive processes, contributing to pathophysiology of stroke and dysfunctions of body metabolism. Besides, since iron plays an important role in both neuroprotection and neurodegeneration, dietary iron homeostasis should be considered with caution. Recently, there has been increased interest in sex-related differences in iron metabolism and iron homeostasis. These differences have not yet been fully elucidated. In this review we will discuss the latest discoveries in iron metabolism, age-related changes, along with the sex differences in iron content in serum and brain, within the healthy aging population and in neurological disorders such as multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, and stroke.

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“…One of these disease categories is neurodegeneration with brain iron accumulation (NBIA) disorders, a group of monogenic inherited disorders characterized by iron deposition in the brain. The second category is composed of a various age-associated neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Friedreich's ataxia, ALS, and stroke (for recent reviews, see literature 13,81,[108][109][110][111] ). We review these two types of ironassociated CNS diseases separately.…”

Section: Deregulated Iron Homeostasis and Neurodegenerative Disordersmentioning

confidence: 99%

Overdosing on iron: Elevated iron and degenerative brain disorders

D’Mello¹,

Kindy

2020

Exp Biol Med (Maywood)

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All cells in organisms ranging from yeast to humans utilize iron as a cofactor or structural element of proteins that function in diverse and critical cellular functions. However, deregulation of the homeostatic mechanisms regulating iron metabolism resulting in a reduction or excess of iron within the cell or outside of it can have serious effects to the health of cells and the organism. This review provides a brief overview of the molecular and cellular mechanisms regulating iron physiology, including the molecules and processes regulating iron uptake, its storage and utilization, its recycling, and its release from the cell, such that the cellular iron levels are sufficient to meet metabolic demand but below those that cause permanent damage. The major focus of review is on the pathological consequences of dysregulation of these homeostatic mechanisms, focusing on the brain. Current advances on the role of iron accumulation to the pathogenesis of rare neurological disorders caused by genetic mutations as well as to the more prevalent and age-associated neurodegenerative diseases are described. Impact statement Brain degenerative disorders, which include some neurodevelopmental disorders and age-associated diseases, cause debilitating neurological deficits and are generally fatal. A large body of emerging evidence indicates that iron accumulation in neurons within specific regions of the brain plays an important role in the pathogenesis of many of these disorders. Iron homeostasis is a highly complex and incompletely understood process involving a large number of regulatory molecules. Our review provides a description of what is known about how iron is obtained by the body and brain and how defects in the homeostatic processes could contribute to the development of brain diseases, focusing on Alzheimer’s disease and Parkinson’s disease as well as four other disorders belonging to a class of inherited conditions referred to as neurodegeneration based on iron accumulation (NBIA) disorders. A description of potential therapeutic approaches being tested for each of these different disorders is provided.

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Iron and oxidizing species in oxidative stress and Alzheimer's disease

Cited by 81 publications

References 52 publications

Are Metal Ions That Make up Orthodontic Alloys Cytotoxic, and Do They Induce Oxidative Stress in a Yeast Cell Model?

Are Metal Ions That Make up Orthodontic Alloys Cytotoxic, and Do They Induce Oxidative Stress in a Yeast Cell Model?

Age-Related Changes and Sex-Related Differences in Brain Iron Metabolism

Overdosing on iron: Elevated iron and degenerative brain disorders

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