Irisin, leptin and adiponectin levels are reduced significantly during fasting

Abstract

BACKGROUND: Ramadan fasting involves refraining from food and liquids from the sunrise till sunset for one month yearly; affecting the sleep pattern and duration, physical activity, and meal number and composition leading to biochemical and physiological changes in the body. Irisin, adiponectin, and leptin induce multiple metabolic effects. OBJECTIVE: The aim of this study is to examine the effect of the Ramadan fasting on serum levels of irisin, adiponectin, and leptin. MATERIALS AND METHODS: A total of sixty healthy students (43 females and 17 males) were recruited, 20.9 years mean age, who were fasting for Ramadan were included in this study. Anthropometry, blood samples and physical activity were determined. Lipid profiles were determined using an enzymatic colorimetric method, and serum levels of irisin, adiponectin, and leptin were measured using Enzyme-linked Immunosorbent Assay. All measurements were measured before Ramadan and in the fourth week of Ramadan. RESULTS: Subjects experienced a significant increase in LDL was determined during Ramadan vs before Ramadan (142.8 vs. 158.1 mg/dl p = 0.03) along with a significant reduction in leptin, adiponectin and irisin concentration during Ramadan compared to before Ramadan (11.6 vs. 8.6; p = 0.000; 4.42 vs. 3.58; p = 0.022; 33.6 vs. 16.3; p = 0.003). A significant positive correlation was found between physical activity and irisin concentration before Ramadan (r = 0.338, p = 0.022). CONCLUSIONS: Ramadan fasting has significant effects on irisin, adiponectin, and leptin levels. Their levels were significantly reduced during Ramadan while LDL level was increased. Irisin level has a significant correlation with the physical activity of the participants.

Evaluation of serum adropin and irisin levels and its association with anthropometric obesity indices and biochemical parameters in Type 2 diabetic patients

“…Several clinical studies reported a significant decrease serum irisin levels in T2DM patients [35,36], despite the fact that the current study didn't assess serum irisin levels in T2DM patients and controls. The only research conducted in Jordan reported a significant decrease in the levels of irisin during Ramadan compared to prior to Ramadan (33.6 vs. 16.3; P = 0.003) in a group of healthy subjects [37].…”

Effects of Christian Orthodox Fasting Versus Time-Restricted Eating on Plasma Irisin Concentrations Among Overweight Metabolically Healthy Individuals

“…Subsequent research demonstrated that irisin levels are positively correlated with fruit consumption and negatively with meat eating [ 23 ], whereas others showed that increased energy intake results in a reduction in irisin levels [ 24 ]. In one study including individuals practicing Ramadan fasting—a type of religious fasting which involves no eating and drinking from sunrise to sunset—Alzoughool et al demonstrated decreased irisin profiles after fasting compared with pre-fasting values [ 25 ]. In a cohort of individuals with metabolic syndrome who underwent an energy-restricted program, weight loss was accompanied by a depletion in irisin levels, which correlated with the reduction in atherogenic-related lipid parameters, independently of changes in BW [ 26 ].…”

Ramadan fasting in health and disease (2019): A narrative review

“…The authors concluded that fasting in Ramadan attenuates inflammation and is beneficial to metabolic health. Alzoughool et al [9] examined the effect of RF on additional metabolic parameters such as serum levels of irisin, adiponectin, and leptin in healthy students. All levels significantly reduced after Ramadan, with irisin levels significantly correlating with the physical activity level of participants.…”