2013
DOI: 10.1111/eci.12196
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Abstract: Serum irisin levels were higher in girls than in boys and correlated negatively with HOMA-IR. They were also independently associated with FBG predominantly in girls, suggesting that this hormone may play a crucial role in glucose metabolism from an early age.

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Cited by 99 publications
(106 citation statements)
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References 26 publications
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“…Such an association suggests the possibility that irisin levels could be predetermined in utero by maternal influences, as previously noted for leptin and adiponectin (10,26). Our data also highlighted that the level of serum irisin in pregnancy was not solely related to this state, since findings were comparable in the nonpregnant state, affirming previous findings using the same irisin ELISA kit from Phoenix Europe (1,30).…”
Section: E515 Irisin In Human Cerebrospinal Fluidsupporting
confidence: 90%
See 1 more Smart Citation
“…Such an association suggests the possibility that irisin levels could be predetermined in utero by maternal influences, as previously noted for leptin and adiponectin (10,26). Our data also highlighted that the level of serum irisin in pregnancy was not solely related to this state, since findings were comparable in the nonpregnant state, affirming previous findings using the same irisin ELISA kit from Phoenix Europe (1,30).…”
Section: E515 Irisin In Human Cerebrospinal Fluidsupporting
confidence: 90%
“…Specifically, some reports have noted an increase in circulating irisin, observing a negative correlation with hemoglobin A 1c , body mass index (BMI), lipids, and irisin or no change in irisin with insulin sensitivity (12,24,28,30). Serum irisin in children, especially girls, has been shown to have a significant negative correlation with fasting blood glucose, suggesting a possible link of irisin to glucose homeostasis from an early age (1).…”
mentioning
confidence: 99%
“…10 FBG was a significant predictor of circulating irisin. 10 Serum irisin concentrations were significantly lower in patients with T2DM compared with the healthy controls.…”
Section: Discussionmentioning
confidence: 83%
“…Similar to the conflicting observations regarding BMI, which have been discussed above, controversy exists. While some studies reported decreased irisin levels in type 2 diabetic subjects compared with lean subjects (Choi et al 2013, Liu et al 2013, Kurdiova et al 2014) and a negative correlation of HOMA-IR with circulating irisin levels in girls (Al-Daghri et al 2013), other studies demonstrated a positive correlation of circulating irisin with HOMA-IR , Ebert et al 2014a. In line, increased irisin levels were found in subjects with metabolic syndrome and higher circulating irisin concentrations have been reported in mothers with prior gestational diabetes (GDM) compared with those without prior GDM (Ebert et al 2014b).…”
Section: Irisin (+) Irisin ( ) Bmp7 (+)mentioning
confidence: 97%