Iris Melanomas

Iris melanoma: a case report and review

“…In a retrospective study of 169 iris melanomas, Shields et al (2001) found that distant metastases had occurred in 3% patients at 5 years after diagnosis and 5% of patients at 10 years. These figures are in good agreement with those of earlier reports (Rones and Zimmerman, 1958;Sunba et al, 1980); Geisse and Robertson, 1985;McGalliard andJohnston, 1989. In addition, Shields et al (2001) evaluated various risk factors and found that metastasis was more likely to develop in older patients who had elevated intra-ocular pressure, and in whom the tumour had invaded the iris root/angle, and extra-ocular extension.…”

Iris melanoma: a case report and review

“…In a retrospective study of 169 iris melanomas, Shields et al (2001) found that distant metastases had occurred in 3% patients at 5 years after diagnosis and 5% of patients at 10 years. These figures are in good agreement with those of earlier reports (Rones and Zimmerman, 1958;Sunba et al, 1980); Geisse and Robertson, 1985;McGalliard andJohnston, 1989. In addition, Shields et al (2001) evaluated various risk factors and found that metastasis was more likely to develop in older patients who had elevated intra-ocular pressure, and in whom the tumour had invaded the iris root/angle, and extra-ocular extension.…”

Angiographic Features of Iris Melanocytic Tumors: Nevus versus Melanoma

“…Similar to our observations, angiographic leakage has been shown in both iris nevi and melanoma [9-11, 13, 14, 20, 21]. Fluorescein leakage, appears to be a secondary finding that reflects incompetence of intrinsic vessels, the extent of which is influenced by tumor pigmentation (masking).…”

“…Our findings are consistent with those reported by Brovkina et al [13] who noted that feeder vessels exclusively occur in iris melanoma. Among published studies, intrinsic vessels were found in 24–100% of iris melanomas and 0–33% of iris nevi [9-11, 13, 14, 20, 21]. Our study identified a significant association of intrinsic vessels (and their leakage) with malignancy.…”

Iris and Ciliary Body Melanomas<subtitle>Ultrasound Biomicroscopy With Histopathologic Correlation</subtitle>

“…Ultrasound biomicroscopy provides useful information about tumor morphology and growth patterns, but a definitive diagnosis is best reached by histopathologic examination. 3 This study demonstrates that UBM findings correlate well with the low-power histopathologic appearance of the tumors imaged in this study. Ultrasound biomicroscopy can provide useful information to the eye care specialists who diagnose and treat anterior segment tumors.…”

Iris melanoma: a case report and review

“…In a retrospective study of 169 iris melanomas, Shields et al (2001) found that distant metastases had occurred in 3% patients at 5 years after diagnosis and 5% of patients at 10 years. These figures are in good agreement with those of earlier reports (Rones and Zimmerman, 1958;Sunba et al, 1980); Geisse and Robertson, 1985;McGalliard andJohnston, 1989. In addition, Shields et al (2001) evaluated various risk factors and found that metastasis was more likely to develop in older patients who had elevated intra-ocular pressure, and in whom the tumour had invaded the iris root/angle, and extra-ocular extension.…”

Angiographic Features of Iris Melanocytic Tumors: Nevus versus Melanoma

“…Similar to our observations, angiographic leakage has been shown in both iris nevi and melanoma [9-11, 13, 14, 20, 21]. Fluorescein leakage, appears to be a secondary finding that reflects incompetence of intrinsic vessels, the extent of which is influenced by tumor pigmentation (masking).…”

“…Our findings are consistent with those reported by Brovkina et al [13] who noted that feeder vessels exclusively occur in iris melanoma. Among published studies, intrinsic vessels were found in 24–100% of iris melanomas and 0–33% of iris nevi [9-11, 13, 14, 20, 21]. Our study identified a significant association of intrinsic vessels (and their leakage) with malignancy.…”

Iris and Ciliary Body Melanomas<subtitle>Ultrasound Biomicroscopy With Histopathologic Correlation</subtitle>

“…Ultrasound biomicroscopy provides useful information about tumor morphology and growth patterns, but a definitive diagnosis is best reached by histopathologic examination. 3 This study demonstrates that UBM findings correlate well with the low-power histopathologic appearance of the tumors imaged in this study. Ultrasound biomicroscopy can provide useful information to the eye care specialists who diagnose and treat anterior segment tumors.…”

Iris melanoma: a case report and review

“…In a retrospective study of 169 iris melanomas, Shields et al (2001) found that distant metastases had occurred in 3% patients at 5 years after diagnosis and 5% of patients at 10 years. These figures are in good agreement with those of earlier reports (Rones and Zimmerman, 1958;Sunba et al, 1980); Geisse and Robertson, 1985;McGalliard andJohnston, 1989. In addition, Shields et al (2001) evaluated various risk factors and found that metastasis was more likely to develop in older patients who had elevated intra-ocular pressure, and in whom the tumour had invaded the iris root/angle, and extra-ocular extension.…”

Angiographic Features of Iris Melanocytic Tumors: Nevus versus Melanoma

“…Similar to our observations, angiographic leakage has been shown in both iris nevi and melanoma [9-11, 13, 14, 20, 21]. Fluorescein leakage, appears to be a secondary finding that reflects incompetence of intrinsic vessels, the extent of which is influenced by tumor pigmentation (masking).…”

“…Our findings are consistent with those reported by Brovkina et al [13] who noted that feeder vessels exclusively occur in iris melanoma. Among published studies, intrinsic vessels were found in 24–100% of iris melanomas and 0–33% of iris nevi [9-11, 13, 14, 20, 21]. Our study identified a significant association of intrinsic vessels (and their leakage) with malignancy.…”

Iris and Ciliary Body Melanomas<subtitle>Ultrasound Biomicroscopy With Histopathologic Correlation</subtitle>

“…Ultrasound biomicroscopy provides useful information about tumor morphology and growth patterns, but a definitive diagnosis is best reached by histopathologic examination. 3 This study demonstrates that UBM findings correlate well with the low-power histopathologic appearance of the tumors imaged in this study. Ultrasound biomicroscopy can provide useful information to the eye care specialists who diagnose and treat anterior segment tumors.…”