Iris indocyanine green videoangiography in diabetic iridopathy.

Parodi, Maurizio Battaglia; Bondel, Elvio; Russo, Daniele; Ravalico, Giuseppe

doi:10.1136/bjo.80.5.416

Cited by 17 publications

(16 citation statements)

References 8 publications

(9 reference statements)

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“…As previously noticed in diabetic iridopathy (Parodi et al 1996), IICGA shows hyperfluorescent areas corresponding to iris translucency, not detectable on IFA examination. The visualisation of the iris pigment epithelium defects can be explained by the infrared activity of IIC-GA, in association with the retroillumination mechanism due to the retinochoroidal fluorescence.…”

Section: Discussionmentioning

confidence: 54%

“…The shades of histological findings correlate with the different expressions of the fluorangiographic features, which have been described as hypoperfusion, microneovascularisation, and anastomotic vessels vessels (Vannas 1969(Vannas , 1972Kottow 1979;Brooks & Gillies 1983. IICGA has been shown to improve the imaging of the iris vascular pattern in diabetic iridopathy and iris arteriovenous communications, thanks to a better penetration of the infrared wavelengths through the iris pigmentation, as well as a minimal dye-leakage in relation to the strong protein binding of the dye and the consequent large protein complex (Parodi et al 1995(Parodi et al , 1996(Parodi et al , 1998.…”

Section: Discussionmentioning

confidence: 99%

“…A solution containing 25 mg of indocyanine green in 5 ml of aqueous solvent was injected intravenously. IICGA images were taken at 1-5 second intervals up to 5-10 minutes (Parodi et al 1995(Parodi et al , 1996.…”

Section: Methodsmentioning

confidence: 99%

“…Some studies indicated that iris indocyanine green angiography (IICGA) is able to evaluate precisely details of the iris vascular pattern in diabetic iridopathy and iris arteriovenous communications, especially as regards hypoperfusion and capillary dilatations (Parodi et al 1995(Parodi et al , 1996(Parodi et al , 1998.…”

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confidence: 99%

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Iris indocyanine green angiography in pseudoexfoliation syndrome and capsular glaucoma

Parodi

Bondel

Saviano

et al. 2000

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: The iris vasculature shows typical changes in pseudoexfoliation syndrome (PXS) revealed by iris fluorescein angiography (IFA), such as hypoperfusion, microneovascularisation, and anastomotic vessels. Iris indocyanine green angiography (IICGA) can visualize more precisely details of the iris vascular pattern, especially as regards hypoperfusion and capillary dilatations. The aim of the present study is to describe the angiographic features of PXS on IFA and IICGA, comparing eyes affected with those not affected by capsular glaucoma. Methods: In a prospective study 42 consecutive patients affected by PXS underwent a complete ophthalmologic examination including IFA and IICGA. Thirty-two eyes were affected by capsular glaucoma. IICGA was performed using IMAGEnet System H1024. Results: IFA can easily detect the microneovascularisation, whereas IICGA allows a better recognition of iris hypoperfusion and anastomotic vessels, and it can reveal iris pigment epithelium defects. While the degree of hypoperfusion was similar in the two subgroups, eyes affected by capsular glaucoma more frequently showed signs of both microneovascularisation (marked stromal tufts and marked plexi), and of anastomotic vessels (peripheral loop, lesser circle and oblique vessels), with statistically significant difference. A clear correlation between hypoperfusion, microneovascularisation, and anastomotic vessels as regards site and extent was not noticed. Conclusions: A different angiographic pattern can be detected in PXS eyes with capsular glaucoma in comparison with eyes without it. Further studies are needed to correlate angiographic features revealed by IFA and IICGA, with clinical features.Key words: pseudoexfoliation syndrome -iris fluorescein angiography -iris indocyanine green angiography.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Iris indocyanine green angiography in pseudoexfoliation syndrome and capsular glaucoma

Parodi

Bondel

Saviano

et al. 2000

Acta Ophthalmologica Scandinavica

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“…In addition, no vascular pattern is hidden by the dark iris stromal pigment, while the previous IA using single FS documents that this pattern was hidden partially by the iris stromal pigment [8] . All this should be attributed to the ICG molecule being the characteristics of spectral absorption and emission in the near-infrared wavelengths, which allow transmission through ocular pigmentations [9,11] .…”

Section: Discussionmentioning

confidence: 99%

A Simultaneous Iris Angiography Technique in Pigmented Rabbits

Zhou

Liu²,

Lin³

et al. 2011

Ophthalmic Res

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Purpose: To report a simultaneous iris angiography (IA) technique combined with the use of indocyanine green (ICG) and fluorescein sodium (FS) in pigmented rabbits. Methods: 15 rabbits were randomly divided into 3 groups according to the dye doses: the dose of the lower-volume group was 2 mg FS and 2 mg ICG; the dose of the moderate-volume group was 5 mg FS and 5 mg ICG, and the dose of the higher-volume group was 8 mg FS and 8 mg ICG. Fifteen IAs were performed by a confocal scanning laser ophthalmoscope and a rapid localization technique giving a flat-on image. Results: Simultaneous digital angiography provided two kinds of a fully dynamic video of iris vessels fluorescein in all pigmented rabbits, which is the same in pigmented and albino rabbits and no vascular pattern was hidden by the iris stromal pigment. Furthermore, dye doses influenced the IA effect in rabbits. The lower-volume dye can demonstrate iris vessels, without obvious leakage, which, however, extinguish rapidly after 10–15 s. In the higher-volume group, vascular imaging lasted longer, but subsequently significant FS and ICG leakage appeared as streams on the surface of the iris until the dye disappeared from the iris vessels; the diffuse and intense aqueous fluid lasted 1 day. The moderate-volume dye displayed vessels clearly by ICG for 300 s, without leakage; FS clear vessels were maintained for about 15–20 s and the structure of the iris became fuzzy due to quick leakage. Conclusions: Simultaneous IA with a rapid localization technique allows high-quality imaging of the pigmented rabbits and the moderate dosage of 5 mg FS and 5 mg ICG is preferred for best visualization.

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The Relationship of Diabetic Retinopathy and Glaucoma

Browning

Rotberg

2010

Diabetic Retinopathy

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Iris indocyanine green videoangiography in diabetic iridopathy.

Cited by 17 publications

References 8 publications

Iris indocyanine green angiography in pseudoexfoliation syndrome and capsular glaucoma

Iris indocyanine green angiography in pseudoexfoliation syndrome and capsular glaucoma

A Simultaneous Iris Angiography Technique in Pigmented Rabbits

The Relationship of Diabetic Retinopathy and Glaucoma

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