Iridoid- and flavonoid-enriched fractions of<i>Cornus sanguinea</i>and<i>Cornus mas</i>exert antioxidant and anti-inflammatory effects and inhibit key enzymes in the treatment of metabolic disorders

Tenuta, Maria Concetta; Loizzo, Monica Rosa; Tundis, Rosa; Dugay, Annabelle; Bouzidi, Chouaha; Marie, Arul; Acquaviva, Rosaria; Cappello, Anna Rita; Deguin, Brigitte

doi:10.1039/d3fo02987e

Cited by 4 publications

(6 citation statements)

References 48 publications

(124 reference statements)

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“…In the α-glucosidase inhibition activity test, a maltose solution was prepared by mixing 12 g of maltose in 300 mL of sodium acetate buffer 50 mM [ 37 ]. The enzyme solution was prepared by using 1 mg of enzyme in 10 mL of ice-cold distilled water.…”

Section: Methodsmentioning

confidence: 99%

“…Pancreatic lipase is an important enzyme that is responsible for the digestion of dietary fats (hydrolyzes 56% of fats), and its inhibition is the most widely studied mechanism for the identification of new potential anti-obesity agents [ 37 ]. Herein, we assessed the pancreatic lipase inhibitory activity of the raspberry extracts by using an assay that we previously described [ 35 ].…”

Section: Methodsmentioning

confidence: 99%

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Chemical Profile and Bioactivity of Rubus idaeus L. Fruits Grown in Conventional and Aeroponic Systems

La Torre,

Loizzo,

Frattaruolo

et al. 2024

Plants

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Raspberry (Rubus idaeus L.) is a fruit of great interest due to its aroma, nutritional properties, and the presence of many bioactive compounds. However, differences among cultivation systems can affect its composition and, consequently, its potential bioactivity. Herein, for the first time, raspberries grown in an aeroponic system were investigated for their chemical profile and antioxidant and anti-inflammatory activity, as well as their enzyme (α-glucosidase and pancreatic lipase) inhibitory properties in comparison to wild and conventionally cultivated fruits. High-performance liquid chromatography coupled with diode array detection (HPLC-DAD) analyses revealed the presence of gallic acid, caffeic acid, chlorogenic acid, p-coumaric acid, ferulic acid, rutin, and catechin in all the samples. The extracts exhibited in vitro anti-inflammatory activity (inhibition of nitric oxide production) regardless of the cultivation method. Of particular interest is the ability of raspberries to inhibit pancreatic lipase. With the exception of the β-carotene bleaching test, the raspberries grown in conventional and aeroponic systems were more active in terms of antioxidants than wild fruits, as evidenced by the ABTS (IC50 in the range 1.6–3.4 μg/mL), DPPH (IC50 in the range 8.9–28.3 μg/mL), and FRAP tests (24.6–44.9 μM Fe(II)/g). The raspberries from aeroponic cultivation were generally able to exert the same bioactivity as those obtained from both conventionally cultivated and wild fruits, supporting the consideration that in the future, this technology could reshape agriculture by mitigating resource constraints, fostering sustainable practices and increasing yields.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Chemical Profile and Bioactivity of Rubus idaeus L. Fruits Grown in Conventional and Aeroponic Systems

La Torre,

Loizzo,

Frattaruolo

et al. 2024

Plants

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“…Cornin and hastatoside were isolated from C. nuttallii Audubon ex Torr. & A.Gray (Tenuta et al, 2023). The iridoid glycoside geniposide has been reported to be the major iridoid of C. suecia L. from Denmark and is accompanied by a small amount of monotropein (Jensen et al, 1973).…”

Section: Three New Iridoids Cornifinsmentioning

confidence: 99%

“…ISSN 2585-8246 -27 -Agrobiodivers Improv Nutr Health Life Qual, 8, 2024 Slovak University of Agriculture in Nitra www.uniag.sk Species of the genus Cornus L. belong to the group of plants whose aboveground organs contain iridoids (Deng et al, 2013;Wang et al, 2022;Li et al, 2022;Tenuta et al, 2023). The presence of iridoids along with phenolic compounds determines the resistance of cornelian cherry trees to various diseases and pests (Blagojević et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Content of Iridoids in the Fruits of Cornus mas L. Cultivars

Levon

2024

Agrobiodivers Improv Nutr health life Qual

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The genetic fund of the cornelian cherry (Cornus mas L.) cultivars at the M.M. Gryshko National Botanical Garden (NBG), National Academy of Sciences of Ukraine includes more than 100 genotypes collected from wild and cultivated plants in Ukraine, and cultivars of Bulgarian, Slovak, English, Austrian and Georgian selection. The genetic fund of the cornelian cherry of the NBG presents a rich variety of biological and economic properties. The fruits of C. mas are valued in the food industry and medicine mainly due to their high content of bioactive compounds such as vitamin C, carotenoids, and anthocyanins. C. mas fruits also have antioxidant activity. We have given the pomological characteristics of 21 studied cultivars of C. mas, and also determined the content of iridoids. Cultivars of C. mas with early, middle, and late fruit ripening periods were studied. To determine the content of iridoids, a spectrophotometric method was used, which consists of the interaction of an iridoid compound with hydroxylamine to form an oxime. The resulting oxime is capable of forming a coordination compound with ferric iron cations. As a result of the study, it was found that the content of iridoids in the fruits of C. mas has a significant difference in cultivars. Among the early ripening cultivars of C. mas, the most promising as a source of iridoids are Pervenets and Samofertylnyi, among the cultivars of C. mas with an average fruit ripening period is Yevgenia, and among the cultivars of C. mas with a late ripening period of fruits, the most promising cultivars are Sokoline and Yuvileinyi Klymenko. These most promising cultivars should be noted for use in the food and medical sectors of the national economy.

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“…They have anti-inflammatory and antioxidant properties, regulate apoptosis [ 6 , 7 ], participate in the activation of antioxidant and detoxifying enzymes [ 8 ], in the induction of signals and activation of receptors [ 9 ], and are involved in cellular interactions [ 10 ]. Through various mechanisms of action, anthocyanins have beneficial effects on many systems and organs, the improvement of which prevents or treats common diseases such as diabetes, atherosclerosis, cancer, and others [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Health-Promoting Properties of Anthocyanins from Cornelian Cherry (Cornus mas L.) Fruits

Szot,

Łysiak,

Sosnowska

et al. 2024

Molecules

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The cornelian cherry is a plant that annually provides fruits, drupe-type, ranging in color from yellow through pink, red, carmine, and almost black. Cornelian cherry bears abundant fruit in temperate climate conditions, which means that its dark-colored fruits can be treated as an excellent source of anthocyanins. After consuming, anthocyanins have a protective function in the human body. Raw fruit extracts and their pure isolates, rich in anthocyanins, have a wide spectrum of health-promoting properties. This review focuses on the health-promoting properties of anthocyanins from fruits of cornelian cherry, documented in research conducted in vitro, in vivo, and in humans. The results obtained so far confirm the beneficial effects of anthocyanins on the blood parameters, whose values are important in predicting and assessing the risk and progression of cardiovascular and metabolic diseases. A beneficial effect on molecular and histopathological changes in target organs such as the heart, brain, kidneys, and liver has also been demonstrated. Anthocyanins from cornelian cherry have a strong antioxidant effect, which explains their protective effects on organs and anticancer effects. Moreover, they have antiglycemic, antihyperlipidemic, anti-inflammatory, and antimicrobial properties. The work highlights the perspectives and directions of necessary research.

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Iridoid- and flavonoid-enriched fractions ofCornus sanguineaandCornus masexert antioxidant and anti-inflammatory effects and inhibit key enzymes in the treatment of metabolic disorders

Abstract: Berry fruits are recognized as a “superfood” due to their high content of bioactive compounds and health benefits.

Cited by 4 publications

References 48 publications

Chemical Profile and Bioactivity of Rubus idaeus L. Fruits Grown in Conventional and Aeroponic Systems

Chemical Profile and Bioactivity of Rubus idaeus L. Fruits Grown in Conventional and Aeroponic Systems

Content of Iridoids in the Fruits of Cornus mas L. Cultivars

Health-Promoting Properties of Anthocyanins from Cornelian Cherry (Cornus mas L.) Fruits

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