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Cited by 78 publications
(73 citation statements)
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References 34 publications
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“…The types 1-3 IP 3 receptors were at the cellular membrane of these cells, which suggests a possible mechanism of cisplatininduced calcium entry through IP 3 receptor activation. This was supported by the observation that the same results were not obtained in human osteosarcoma cells, which in addition did not show the presence of types 1-3 IP 3 receptors at cell membrane [88]. Arsenic trioxide (As 2 O 3 ) similarly caused an increase in intracellular calcium which was dependent on calcium release from the intracellular calcium stores through the activation of IP 3 receptors [88].…”
Section: Gpcrsupporting
confidence: 68%
See 1 more Smart Citation
“…The types 1-3 IP 3 receptors were at the cellular membrane of these cells, which suggests a possible mechanism of cisplatininduced calcium entry through IP 3 receptor activation. This was supported by the observation that the same results were not obtained in human osteosarcoma cells, which in addition did not show the presence of types 1-3 IP 3 receptors at cell membrane [88]. Arsenic trioxide (As 2 O 3 ) similarly caused an increase in intracellular calcium which was dependent on calcium release from the intracellular calcium stores through the activation of IP 3 receptors [88].…”
Section: Gpcrsupporting
confidence: 68%
“…MeHg doubled intracellular inositol phosphate levels at concentrations above 3 μM in vitro in rat cerebellar granule neurons [89]. [88]. Cisplatin also increased [Ca 2+ ] i in a concentration-dependent manner in human cervix adenocarcinoma cells but not in human osteosarcoma cells.…”
Section: Gpcrmentioning
confidence: 88%
“…The role of calpains in apoptosis is reflected in a growing list of substrates, including p53, Bcl-2, Bax, apoptosis-inducing factor, caspases, and cytoskeletal proteins (14,36,(53)(54)(55). Calpain activity is Ca 2ϩ -dependent, and calpain activation in response to Ca 2ϩ signaling is an early event in CDDPinduced apoptosis (56), mediating Bid cleavage (15) and preceding apoptosis-inducing factor release and caspase-9/-3 activation (36). Furthermore, a decrease in Ca 2ϩ signaling could prevent PARC processing and promote chemoresistance.…”
Section: Discussionmentioning
confidence: 99%
“…By inducing a Ca 2ϩ influx in chemosensitive and chemoresistant OVCA cells with ionomycin, PARC cleavage and apoptosis were induced in both cell types. Ionomycin treatment did not induce PARC processing in the IOSE397-sensitive immortalized ovarian surface epithelial cells nor in the chemoresistant OVCA433 cells, possibly because of different Ca 2ϩ regulatory mechanisms (56,58).…”
Section: Discussionmentioning
confidence: 99%
“…, where F t is the value of fluorescence already described above; F max is the fluorescence value in the Ca 2+ -saturated condition obtained by treating cells with the ionophore, 4-bromo A-23187 (10 lM; Invitrogen) dissolved in a solution containing 2 mM Ca 2+ ; F min is the fluorescence value in the absence of Ca 2+ obtained by applying a solution containing 10 mM EGTA and K d is the dissociation constant taken from the datasheet of Fluo-4 AM (Takahashi et al 1999;Cristofol et al 2004;Splettstoesser et al 2007).…”
Section: Cell Culturesmentioning
confidence: 99%