Iontophoresis of Vidarabine Monophosphate for Herpes Orolabialis

Lp, Gangarosa; Jm, Hill; Bl, Thompson; Leggett, Cecilia B.; Jp, Rissing

doi:10.1093/infdis/154.6.930

Cited by 28 publications

(13 citation statements)

References 12 publications

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“…We believe the delivery method used by us, i.e. iontophoresis, accounts for the observed effectiveness of Ara-AMP (29), but no differences between ACV and placebo were found after iontophoresis. Lack of effectiveness of ACV iontophoresis may be related to a high solution pH of 10.6 obtained on dissolving ACV powder.…”

Section: Treatment Of Herpes Simplex Cutaneous and Orolabial Infectionsmentioning

confidence: 79%

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Iontophoresis for Enhancing Penetration of Dermatologic and Antiviral Drugs

Gangarosa

Ozawa

Ohkido

et al. 1995

The Journal of Dermatology

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Iontophoresis is the process of introducing ionic drugs into the body for therapeutic purposes. Although iontophoresis has the potential for systemic therapy, it has mainly been used for local therapy at body surfaces. Many ionic drugs are available including lidocaine, epinephrine, methylprednisolone succinate, dexamethasone phosphate, several antivirals, various antibiotics, and other specific drugs. The use of an indicated ionic drug by iontophoresis offers a broad potential for promoting the development of more effective therapies in dermatology. Iontophoresis of ionized drugs provided a 20-60 fold increase in penetration over topical application. Iontophoresis for dermatological use requires that: a) a charged drug be placed at an electrode having a polarity the same charge as the drug, b) the condition or disease under treatment be at or near the body surface, and c) a modern, sophisticated source of direct current, with appropriate accessories, be used. The current source must have features that make it not only effective, but also safe for application to the patient. Modern systems for application of drugs by iontophoresis have features that make the process simple and efficient for use in practice. Iontophoresis has a long history of use, having been suggested for various therapies for many years in medicine, physical therapy and dentistry. Pilocarpine iontophoresis is a preferred method for cystic fibrosis detection. Also, lidocaine iontophoresis has been advocated to anesthetize the tympanic membrane before myringotomy. Anesthesia of the skin to a depth of 1.0 cm or more has been reported in double-blind studies of human volunteers. Local anesthesia by iontophoresis was reported to be effective for: 1) cutaneous cutdowns in patients requiring kidney dialysis, 2) delicate eyelid surgery, as the sole anesthetic, 3) preinjection topical anesthesia, and 4) shave biopsies of skin lesions. The use of iontophoresis for treating difficult cases of hyperhydrosis is quite popular among dermatologists. The present report emphasizes uses of iontophoresis in dermatology and is divided into discussion of studies using iontophoresis for postherpetic neuralgia, local anesthesia, antiviral therapy, and for corticosteroid therapy of nonspecific inflammatory lesions. Over 1250 patients have been treated for postherpetic neuralgia by corticosteroid iontophoresis at 6 medical centers with 60-80% of patients showing a major therapeutic response with return to a tolerable pain level. Double-blind studies of varicella zoster (active and postherpetic) and herpes simplex have proven that iontophoresis is a valuable modality for treating viral diseases of the skin. Many other uses for iontophoresis have been proposed in the literature that involve several hundred research papers, several textbooks and many book chapters. Review of the literature supports the concept that iontophoresis provides an optimal method for drug application in therapy of surface tissues.

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Section: Treatment Of Herpes Simplex Cutaneous and Orolabial Infectionsmentioning

confidence: 79%

“…The animal studies described above provided a rationale for antiviral iontophoresis; thus we proceeded to perform a double-blind, placebocontrolled clinical trial in human volunteers (29). An IND protocol was approved by FDA for studying Ara-AMP and ACV.…”

Section: Treatment Of Herpes Simplex Cutaneous and Orolabial Infectionsmentioning

confidence: 99%

Iontophoresis for Enhancing Penetration of Dermatologic and Antiviral Drugs

Gangarosa

Ozawa

Ohkido

et al. 1995

The Journal of Dermatology

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“…Harris (6) , em seguida, descreveu as primeiras aplicações da iontoforese na medicina, utilizando a técnica para o transporte das seguintes substâncias: sulfato de cobre para o tratamento de tinea pedis e cervicite crônica, sulfato de zinco para o tratamento de otite crônica e rinite vasomotora, nitrato de prata para o tratamento de osteoartrite e artrite reumatóide. A iontoforese também foi utilizada no transporte de pilocarpina transcutânea em pacientes com fibrose cística (7) , de corticosteróides para o tratamento de condições músculo-esqueléticas e urológicas (8) , de anestésicos locais na membrana timpânica e na mucosa periodontal (9)(10) , de fluoreto de sódio para redução da sensibilidade dental (11) , de monofosfato de vidarabina para o tratamento de Herpes simplex (12) e de gentamicina no controle de queimaduras auriculares (13) .…”

Section: Introductionunclassified

Iontoforese no transporte ocular de drogas

Silva-Cunha¹

2004

Arq. Bras. Oftalmol.

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“…Iontopho- resis has also been called iontherapy or electroosmosis. Iontophoresis has a long history of being used to enhance penetration of charged molecules through the skin [9][10][11][12][13][14]. More specifically, recent in vitro studies have demonstrated increased transdermal transport of acyclovir with iontophoresis [15][16][17], although those investigations used clinically impractical treatments of 30 min to 7 h of iontophoresis.…”

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confidence: 99%