Iontophoresis of 22NA and 131I Into the Inner Ear

Do Disinfectants Induce Ototoxicity and Cause Structural Damage to the Inner Ear?

“…18,19 Stecker et al found that 2% of ions from the middle ear crossed into the inner ear within 30 min, indicating potential damage. 20 Cochlear hair cells in mammals, including humans, 21,22 lack regenerative capacity, requiring caution in disinfectant use to prevent harm.…”

“…Research shows that ototoxic substances can penetrate the round window membrane, damaging the inner ear and disrupting hair cell function, leading to hearing loss 18,19 . Stecker et al found that 2% of ions from the middle ear crossed into the inner ear within 30 min, indicating potential damage 20 . Cochlear hair cells in mammals, including humans, 21,22 lack regenerative capacity, requiring caution in disinfectant use to prevent harm.…”

Ototoxicity of ear drops in patients suffering from chronic otitis media

“…Morphological changes in the round window membrane in chronic otitis media have been reported (Belluci et al, 1972;Goycoolea, 1978), the round window membrane functioning as a semipermeable membrane, and Rhodes (1980) demonstrated the passing of horseradish peroxidase through the round window into the cochlea. Stecker and Cody (1966) reported the permeability of the round window membrane for Na 22 and I 131 . Sakata and Umeda (1976) and Fradis et al, (1985) treated tinnitus and Meniere's disease respectively by intratympanic injection of lidocaine hydrochloride assuming the resorption of lidocaine through the oval window into the inner ear.…”