2017
DOI: 10.18632/aging.101225
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Abstract: Cellular senescence is associated with aging and is considered a potential contributor to age-associated neurodegenerative disease. Exposure to ionizing radiation increases the risk of developing premature neurovascular degeneration and dementia but also induces premature senescence. As cells of the cerebrovascular endothelium are particularly susceptible to radiation and play an important role in brain homeostasis, we investigated radiation-induced senescence in brain microvascular endothelial cells (EC). Usi… Show more

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Cited by 33 publications
(37 citation statements)
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References 70 publications
(91 reference statements)
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“…At day 5, cell loss and cellular hypertrophy were observed. The enlargement and flattening of cells is consistent with radiationinduced acquisition of a senescent phenotype [27]. While the cells spread to provide greater coverage of the collagen-coated dish, confluency was still reduced, hence all subsequent experiments were performed at day 1 and 3 post-irradiation to reduce non-specific induction of thrombosis via collagen exposure.…”
Section: Effect Of Radiation On Hcmec/d3 Cell Confluencymentioning
confidence: 66%
“…At day 5, cell loss and cellular hypertrophy were observed. The enlargement and flattening of cells is consistent with radiationinduced acquisition of a senescent phenotype [27]. While the cells spread to provide greater coverage of the collagen-coated dish, confluency was still reduced, hence all subsequent experiments were performed at day 1 and 3 post-irradiation to reduce non-specific induction of thrombosis via collagen exposure.…”
Section: Effect Of Radiation On Hcmec/d3 Cell Confluencymentioning
confidence: 66%
“…It has been demonstrated that IR induces senescence in various cell types in the CNS [ 12 15 ]. In addition, certain similarities exist in the gene expression profiles of irradiated primary microglia and normal aging microglia [ 16 ].…”
Section: Resultsmentioning
confidence: 99%
“…Senescent cells secrete numerous cytokines and matrix metalloproteases (MMPs) and sustain oxidative and genotoxic damage, which consequently contribute to tissue dysfunction and the aging process [ 11 ]. Following IR stimulation, the accumulation of DNA damage and the generation of oxidative stress are capable of triggering senescence in normal cells [ 12 15 ]. Murine neural stem cells could enter irreversible proliferative arrest, with features of senescence, after in vitro and in vivo IR treatment [ 12 , 13 ].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…5). However, in an in vitro study, Kalamida et al found ionizing radiation could trigger perinuclear accumulation of the autophagosomal proteins and repression of the autophagolysosomal flux in human umbilical vein endothelial cells, suggesting against the blockage of autophagic flux may contribute to radio-resistance 40,41 . The difference might owe to the difference between in vivo and in vitro studies, and different radiation dosage and animal models.…”
Section: Discussionmentioning
confidence: 99%