2016
DOI: 10.18632/aging.100989
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Abstract: The cell surface proteoglycan syndecan 1 (SDC1) is overexpressed in the malignant breast stromal fibroblasts, creating a favorable milieu for tumor cell growth. In the present study, we found that ionizing radiation, a well-established treatment in human breast cancer, provokes premature senescence of human breast stromal fibroblasts in vitro, as well as in the breast tissue in vivo. These senescent cells were found to overexpress SDC1 both in vitro and in vivo. By using a series of specific inhibitors and siR… Show more

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Cited by 44 publications
(68 citation statements)
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References 79 publications
(106 reference statements)
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“…In recent years, increasing numbers of studies have been focusing on establishing methods to control cancer development, and inducing senescence in cancer cells is an effective treatment. The means to induce cancer cell senescence include inhibiting telomerase activity, ionizing radiation, and administration of certain drugs or chemicals . Several commercial anti‐cancer drugs have been found to induce cell senescence.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In recent years, increasing numbers of studies have been focusing on establishing methods to control cancer development, and inducing senescence in cancer cells is an effective treatment. The means to induce cancer cell senescence include inhibiting telomerase activity, ionizing radiation, and administration of certain drugs or chemicals . Several commercial anti‐cancer drugs have been found to induce cell senescence.…”
Section: Discussionmentioning
confidence: 99%
“…The means to induce cancer cell senescence include inhibiting telomerase activity, ionizing radiation, and administration of certain drugs or chemicals. [33][34][35][36][37][38][39] Several commercial anti-cancer drugs have been found to induce cell senescence. Among them, doxorubicin might be one of the most intensively studied.…”
Section: Discussionmentioning
confidence: 99%
“…Subsequently, the methylation status of lncRNA MEG3 was also examined using the UCSC Xena browser [26][27][28].…”
Section: Ucsc Cancer Genomics Browser Analysismentioning
confidence: 99%
“…We recently reported specific recognition of senescent cells in biological material including cultured cells, fresh/frozen, and archival (formalin‐fixed and paraffin‐embedded, FFPE) tissues, applying the Sudan Black B (SBB) histochemical dye (Georgakopoulou et al ., ; Galanos et al ., ; Liakou et al ., ; Petrakis et al ., ). SBB reacts with lipofuscin, a non degradable aggregate of oxidized proteins, lipids, and metals (Jung et al ., ).…”
mentioning
confidence: 99%
“…SBB reacts with lipofuscin, a non degradable aggregate of oxidized proteins, lipids, and metals (Jung et al ., ). Lipofuscin accumulates in senescent cells, as a by‐product of the senescent process, and should be considered as a new ‘hallmark’ of senescence (Jung et al ., ; Georgakopoulou et al ., ; Galanos et al ., ; Liakou et al ., ; Petrakis et al ., ). On the contrary, the most widely used method, measuring senescence‐associated βgalactosidase activity (SA‐β‐gal; Dimri et al ., ), is applicable only in fresh samples.…”
mentioning
confidence: 99%