2017
DOI: 10.1016/j.mrrev.2017.01.001
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Recent epidemiology studies highlighted the detrimental health effects of exposure to low dose and low dose rate ionizing radiation (IR): nuclear industry workers studies have shown increased leukaemia and solid tumour risks following cumulative doses of <100mSv and dose rates of <10mGy per year; paediatric patients studies have reported increased leukaemia and brain tumours risks after doses of 30-60mGy from computed tomography scans. Questions arise, however, about the impact of even lower doses and dose rat… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
93
0
2

Year Published

2018
2018
2023
2023

Publication Types

Select...
4
3

Relationship

2
5

Authors

Journals

citations
Cited by 122 publications
(95 citation statements)
references
References 280 publications
0
93
0
2
Order By: Relevance
“…Classic biodosimetry assays, such as dicentric or micronucleus, can provide accurate dose estimates. However, they are time-consuming and low-throughput methodologies (1,60,61), difficult to apply in an emergency situation where large sample screenings in a short period of time are required (within 24 h). In this study we demonstrated the usefulness of nanopore sequencing to precisely identify radiationresponsive transcripts, making this a technology of great interest for biological dosimetry.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Classic biodosimetry assays, such as dicentric or micronucleus, can provide accurate dose estimates. However, they are time-consuming and low-throughput methodologies (1,60,61), difficult to apply in an emergency situation where large sample screenings in a short period of time are required (within 24 h). In this study we demonstrated the usefulness of nanopore sequencing to precisely identify radiationresponsive transcripts, making this a technology of great interest for biological dosimetry.…”
Section: Discussionmentioning
confidence: 99%
“…Blood samples from a previous study (13,36) were analyzed to monitor the radiation response in vivo of apolipoprotein B mRNA editing enzyme catalytic subunit 3H (APOBEC3H) and FDXR. This cohort was comprised of patients with the following cancer diagnoses (n): endometrial (4), breast (5), lung (4), prostate (3), esophageal (2) and colon (1). Patients received intensity modulated radiotherapy using a linear accelerator.…”
Section: Radiotherapy Patient Samplesmentioning
confidence: 99%
See 1 more Smart Citation
“…The exposures to high doses of IR can cause significant impact on PTMs . IR‐induced alterations in global proteome profiles highlights the broad range of changes in the cellular processes that are regulated by PTMs . DNA damages are recognized by sensor proteins, which include the Mre11‐Rad50‐Nbs1 complex, BRCA1/2 proteins, ATM/ATR, DNA‐dependent protein kinase (DNA‐PK), checkpoint kinases 1/2 (Chk1/2), and poly (ADP‐ribose) polymerase.…”
Section: Introductionmentioning
confidence: 99%
“…A large, international cohort study strongly supported that long-term exposure to low-dose IR (LDIR) increases the risk of leukemia, although the increase is only minuscule (4)(5)(6). However, recent epidemiological studies highlighted the detrimental effect of persistent exposure to LDIR, and research on nuclear industry workers has demonstrated increased cancer mortality risks following a cumulative dose of <100 mSv and dose rates of <10 mSv per year (7), particularly in solid cancers, by the linear non-threshold model (8). As the extensive use of IR in the medical industry, including radiodiagnosis and radiotherapy, is justified and has been well-studied, the aim of the present study was to focus on the health effects of occupational and environmental IR exposure in the nuclear industry.…”
Section: Introductionmentioning
confidence: 99%