Ionizing Radiation as a Risk Factor for Cataract: What about Low-Dose Effects?

Jacob, Sophie

doi:10.4172/2155-9570.s1-005

Cited by 10 publications

(12 citation statements)

References 27 publications

(45 reference statements)

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“…Many excellent reviews summarize the data across multiple populations supporting the ICRP threshold reduction [1,2,4,5,26]. The current review will describe the data that is specific to interventionist populations.…”

Section: Radiation Exposure and Cataract Developmentmentioning

confidence: 99%

“…This is presumed by the current International Commission on Radiological Protection (ICRP) model, which defines exposure thresholds below which opacities do not form. New data suggests that cataracts may form stochastically, without a threshold dose and potentially in response to the damage of a single cell [5]. Multiple studies in non-interventionist populations have predicted threshold values statistically equivalent to or near zero [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…Given the avascular nature of the lens, there is no mechanism for removal of damaged cells, and they accumulate with time to form a cataract. An intermediate stage in cataract formation, posterior subcapsular opacification, occurs prior to the development of symptomatic cataract as these cells accumulate [5]. Although this process is irreversible, symptomatic cataract can be avoided if radiation exposure is limited during this intermediate stage.…”

Section: Introductionmentioning

confidence: 99%

“…Although this process is irreversible, symptomatic cataract can be avoided if radiation exposure is limited during this intermediate stage. Cataract formation is believed to relate to the genotoxicity of radiation exposure [5]. This is supported by heightened cataractogenesis in animals with mutations in genes critical to the regulation of cell division and DNA repair, including Atm, Brca1, and Rad9 [4,11].…”

Section: Introductionmentioning

confidence: 99%

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Radiation-Induced Cataractogenesis: A Critical Literature Review for the Interventional Radiologist

Seals

Lee

Cagnon

et al. 2015

Cardiovasc Intervent Radiol

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Extensive research supports an association between radiation exposure and cataractogenesis. New data suggests that radiation-induced cataracts may form stochastically, without a threshold and at low radiation doses. We first review data linking cataractogenesis with interventional work. We then analyze the lens dose typical of various procedures, factors modulating dose, and predicted annual dosages. We conclude by critically evaluating the literature describing techniques for lens protection, finding that leaded eyeglasses may offer inadequate protection and exploring the available data on alternative strategies for cataract prevention.

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Section: Radiation Exposure and Cataract Developmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Radiation-Induced Cataractogenesis: A Critical Literature Review for the Interventional Radiologist

Seals

Lee

Cagnon

et al. 2015

Cardiovasc Intervent Radiol

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“…Основной вывод заключается в том, что данные несовместимы с порогом зависимости «доза-эффект» более 0,7 Гр и что нижний предел пороговой дозы близок к современному пределу дозы для хрусталика глаза (150 мЗв), хотя это следует проверить с учетом неопределенности в дозиметрии. В настоящее время считается, что допустимый предел дозы профессионального облучения составляет всего 20 мЗв в год [12,17].…”

Section: роль ионизирующего излучения в развитии катаракты у человекаunclassified

Triggering factors and pathogenesis of radiation cataract

et al. 2015

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Cataract is one of the most common eye diseases in the world. Many factors, including genetic, metabolic, nutritional, and environmental, are involved in its formation. It is necessary to know main causal agents and cellular mechanism of cataractogenesis. The tissue of the lens is considered radiosensitive, thus, lens opacities are possible late effects of exposure to ionizing radiation. The use of medical radiation for both diagnostic and therapeutic purposes grows worldwide. At the same time, there continues to be much confusion regarding the actual threshold dose of radiation exposure for cataract formation. Eye safety and the risk of cataract development are not entirely clear. However, with an ever-widening range of interventional procedures, one should take attempts to reduce the risk for radiation cataract.

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