1999
DOI: 10.1111/j.1469-7793.1999.729ab.x
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Abstract: Cloning of ion-coupled transporters and their heterologous expression has allowed insights on the molecular mechanism of translocation (Hediger et al. 1987;Lester et al. 1994). Among the best-studied systems so far are those involved in the reuptake of amino acid neurotransmitters, such as the GAT1 transporter (Mager et al. 1993) or the 5-hydroxytryptamine (5-HT) transporter (Mager et al. 1994). Electrophysiological investigations on these molecules have revealed interesting aspects of the ion and substrate t… Show more

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Cited by 45 publications
(87 citation statements)
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“…We compared the properties of the leak current in the two transporters to verify its usefulness in distinguishing the behavior of our chimeras. The leak current was operatively determined as the difference between current level in the presence of Na ϩ or K ϩ and current level in TMA ϩ solution (1,2). The results, shown in Fig.…”
Section: Resultsmentioning
confidence: 99%
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“…We compared the properties of the leak current in the two transporters to verify its usefulness in distinguishing the behavior of our chimeras. The leak current was operatively determined as the difference between current level in the presence of Na ϩ or K ϩ and current level in TMA ϩ solution (1,2). The results, shown in Fig.…”
Section: Resultsmentioning
confidence: 99%
“…We have speculated that this may be so to favor absorption of Na ϩ from the K ϩ -rich intestinal lumen (1). The reduction of the membrane current by an organic substrate, which may even be accompanied by transport (3,21), would represent a slowing down of the turnover rate, instead of its increase.…”
Section: Discussionmentioning
confidence: 99%
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“…These charge movements occur also in the absence of the substrate, and then they manifest as a transient current response to rapid voltage steps, the so-called pre-steady state currents. However, saturating amounts of substrate disperse I pre and favor transport currents (Loo et al, 1993;Lester et al, 1996;Mager et al, 1996;Nussberger et al, 1997;Bossi et al, 1999Bossi et al, , 2011Cherubino et al, 2010). In a previous study on maize SUT1, we showed that in the absence of Suc, the binding of protons to the transporter manifests in rapidly decaying pre-steady state currents (I pre ; Figure 2A) and in voltage-dependent membrane capacitance changes (Carpaneto et al, 2010).…”
Section: Sucralose a Competitive Inhibitor Of Suc-induced Sut1-mediamentioning
confidence: 75%
“…The cation dependency, amino acid uptake activity and kinetic properties of KAAT1 have subsequently been studied by many workers (e.g. Bossi et al, 1999a;Bossi et al, 1999b;Bossi et al, 2000;Peres and Bossi, 2000;Vincenti et al, 2000;Castagna et al, 2002;Liu et al, 2003).…”
Section: Basal and Lateral Vs Basolateral Membranes In Insect Epitheliamentioning
confidence: 99%