Iododerma occurring after orally administered iopanoic acid

Boudoulas, O.

doi:10.1001/archderm.123.3.387

Cited by 12 publications

(13 citation statements)

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“…It has been reported extensively in the literature since 1854. [81][82][83][84][85][86][87][88][89][90][91][92][93][94][95][96][97] The lesions may present as papules, vesicles, and pustules but also as erythematous, urticarial, furuncular, carbuncular, bullous, and sterile vegetating lesions that may ulcerate. Lesions appear on the seborrheic regions (face, neck, and back), but they may be more widespread and involve the whole body.…”

Section: Iodinementioning

confidence: 99%

Drug-Induced Acneiform Eruption

Du‐Thanh

Kluger

Bensalleh

et al. 2011

American Journal of Clinical Dermatology

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Drug-induced acne is a specific subset of acne that usually has some specific features, namely a monomorphic pattern, an unusual location of the lesions beyond the seborrheic areas, an unusual age of onset, a resistance to conventional acne therapy and, of course, the notion of a recent drug introduction. Many drugs can be responsible for such a clinical pattern. Corticosteroids, neuropsychotherapeutic drugs, antituberculosis drugs, and immunomodulating molecules are the more classical drugs associated with induced acne. Recently, new drugs, mainly targeted therapy in the field of oncology, such as epidermal growth factor receptor inhibitors, have been associated with an increased frequency of this adverse effect. Disruption of the culprit drug is rarely mandatory in cases of drug-induced acne. Close cooperation between the dermatologist and medical staff in charge of the patient is an important challenge to achieve optimal management of the initial disease.

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Section: Iodinementioning

confidence: 99%

Drug-Induced Acneiform Eruption

Du‐Thanh

Kluger

Bensalleh

et al. 2011

American Journal of Clinical Dermatology

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“…3 Iododerma induced by oral or parental administration of iodide-containing radiographic contrast medium or from treatment with radioactive iodine-131 for hyperthyroidism has also been described. 3,4 Topical iodine use has only rarely been associated with iododerma. [5][6][7] In this report, we describe a case of an iododerma-like eruption developing after topical application of 10% povidoneiodine to the lower extremities.…”

Section: Introductionmentioning

confidence: 99%

Use of topical povidone‐iodine resulting in an iododerma‐like eruption

Massé

Falanga

Zhou

2008

The Journal of Dermatology

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Iododerma is a rare skin eruption that is usually induced by the systemic use of iodide-containing radiographic contrast medium or treatment with oral potassium iodide therapy. Iododerma has also rarely been reported to occur following topical application of iodine. We herein report the case of a 42-year-old male who developed multiple pinpoint pustules on both lower extremities. Three days after the eruption began, the patient started applying topical 10% povidone-iodine solution to the lesions. During this treatment, the lesions enlarged into multiple 2-9-cm pus-filled bullae, limited to the treated areas. Lesional bacterial culture swab and Gram stain were negative. Blood cultures were also negative and the patient's white blood cell count was normal. A punch biopsy specimen revealed pseudoepitheliomatous hyperplasia and dermal-epidermal separation with epidermal necrosis and underlying abscess formation. A superficial and deep perivascular, interstitial and perifollicular infiltrate containing numerous neutrophils, with abscess formation and eosinophils was also seen. This histology was consistent with iododerma and the patient's lesions involuted following cessation of topical iodine use, leaving only post-inflammatory hyperpigmentation. In summary, our patient likely had a folliculitis that was then treated with topical povidone-iodine that led to iododerma. Although it remains possible that the reaction was an unusual contact hypersensitivity response, the ulceration, pseudoepitheliomatous hyperplasia and abscess formation do support an iododerma-like eruption.

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“…Areas of high sebaceous gland density are most commonly affected. 1 Some theorize that iododerma represents a cell-mediated hypersensitivity reaction; however, the precise mechanism is unknown.…”

Section: Discussionmentioning

confidence: 99%