Involvement of Vitamin D3 in the Aging Process According to Sex

Trifan, Daniela Florina; Tirla, Adrian Gheorghe; Moş, Călin; Danciu, Adrian; Bodog, Florian; Manole, Felicia; Ghitea, Timea Claudia

doi:10.3390/cosmetics10040114

Cited by 3 publications

(3 citation statements)

References 43 publications

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“…The role of homocysteine in vascular pathology has been extensively studied, revealing that elevated homocysteine levels are linked to increased risks of cardiovascular disease [ 24 ], cerebrovascular [ 25 ], vitamin D deficiency [ 26 , 27 ] and peripheral vascular disease [ 28 ], primarily due to heightened inflammation. Various epidemiological studies have noted this association, prompting intensive research into the precise mechanisms by which homocysteine contributes to these conditions, including changes to endothelial cell surfaces, platelet activation, and peroxide-induced oxidative damage [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Is There a Connection between Hyperhomocysteinemia and the Cardiometabolic Syndrome?

Tarcau,

Negru,

Ghitea

et al. 2024

Biomedicines

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This study investigates the distribution of hyperhomocysteinemia and cardiovascular metabolic syndrome (SM) among participants, shedding light on their prevalence and co-occurrence within the study cohort. Through an analysis of demographic characteristics and health parameters, including age, gender, and body mass index (BMI), alongside nutritional data, correlations between these factors and health risks are explored. Results reveal a notable prevalence of hyperhomocysteinemia, with 45.3% of participants exhibiting this condition. Furthermore, 31.4% of the cohort does not present hyperhomocysteinemia or SM, while 23.3% shows SM without hyperhomocysteinemia. The study underscores gender-specific dietary recommendations due to significant variations in nutrient intake patterns. Additionally, inverse correlations between health risks like obesity, hypertension, and hypercholesterolemia and nutrient requirements highlight the need for tailored dietary interventions. Age-related changes in nutrient needs and the positive correlation between physical activity levels and certain nutrient demands further emphasize the importance of personalized dietary strategies. Variations in nutrient intake by gender, inverse correlations with health risks, and age-related changes underscore the need for tailored dietary strategies. These findings provide valuable insights for healthcare professionals in developing targeted nutritional interventions to mitigate disease risk and promote overall health and well-being.

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Section: Discussionmentioning

confidence: 99%

Is There a Connection between Hyperhomocysteinemia and the Cardiometabolic Syndrome?

Tarcau,

Negru,

Ghitea

et al. 2024

Biomedicines

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“…A diminished noradrenaline level can lead to energy depletion, difficulties in concentration, lack of drive, emotional instability, and heightened pain sensitivity, and can potentially contribute to a depletion of other neurotransmitters under conditions of chronic stress [24]. Deficiency in noradrenaline can arise from an insufficient intake of tyrosine or essential nutrients, such as vitamin B6, folic acid, vitamin C, vitamin D [25,26], copper, and magnesium (similar to dopamine deficiency) [27,28].…”

Section: Discussionmentioning

confidence: 99%

Catecholamine Variations in Pediatric Gastrointestinal Disorders and Their Neuropsychiatric Expression

Matiș,

Alexandru,

Ghitea

2023

Biomedicines

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The interplay between the central nervous system and the intestinal environment hinges on neural, hormonal, immune, and metabolic reactions. Over decades, significant effort has gone into exploring the link between the digestive system and the brain. The primary objective of this study is to assess catecholamine levels in children with neuropsychiatric disorders. We aim to examine how these levels impact the mental and physical wellbeing of these children, with a specific focus on psychoemotional symptoms and cognitive performance. Our research seeks to identify the significance of modifying neurotransmitter levels in pediatric medical interventions, ultimately striving to reduce mental health risks and enhance children’s future development. A total of 135 individuals were chosen to partake, and they engaged in regular monthly consultations according to established study protocols. Clinical evaluations were conducted in a medical environment, encompassing the observation of constipation, diarrhea, and additional gastrointestinal anomalies not confined to constipation or diarrhea. This entailed the assessment of neurotransmitter imbalances, with a specific focus on dopamine, adrenaline, noradrenaline, and the noradrenaline/adrenaline ratio. Gastrointestinal disorders are indicative of imbalances in catecholamines, with lower gastrointestinal problems being correlated with such imbalances. In subjects with psychiatric disorders, a more pronounced dopamine and noradrenaline/adrenaline ratio was observed, while elevated adrenaline levels were associated with psychoanxiety disorders.

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“…Furthermore, serotonin imbalance can be associated with inappropriate eating behavior, which, in turn, is correlated with the development of metabolic syndrome [20]. At the same time, the presence of metabolic syndrome (MS) contributes to inflammation, increased susceptibility to infections [21,22], lower vitamin D levels [23], and a compromised immune response [24]. It is imperative to manage MS through the available approaches, including dietary therapy [25], probiotic therapy [26,27], and physical activity [28], as they represent essential means for addressing this complex health condition.…”

Section: Discussionmentioning

confidence: 99%

Variety of Serotonin Levels in Pediatric Gastrointestinal Disorders

Matiș,

Daina,

Maris

et al. 2023

Diagnostics

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(1) Serotonin primarily regulates our emotions. A complex process, which includes dysfunctions in gastrointestinal motility and deregulation of the gene responsible for serotonin reuptake (SERT), is implicated in the pathophysiology of irritable bowel syndrome (IBS). This also encompasses changes in intestinal microbiota, the response to stress, the intricate interplay between the brain and the digestive tract, heightened sensitivity to visceral stimuli, and low-grade inflammation. This paper aims to investigate the effectiveness of probiotic therapy in managing gastrointestinal and neuropsychiatric symptoms related to serotonin levels, with a focus on individuals with serotonin deficiency and those with normal serotonin levels experiencing gastrointestinal disorders. (2) The study involved 135 pediatric patients aged 5–18 years with gastrointestinal disturbances, including constipation, diarrhea, and other symptoms, such as nausea, flatulence, feeling full, or gastrointestinal pain. (3) Serotonin testing was performed, and administering probiotics appeared to be effective in addressing serotonin deficiency and other gastrointestinal disorders. (4) Serotonin’s pivotal role in regulating neurotransmitter secretion and its impact on neuropsychiatric health, coupled with gender differences and age-related declines, underscore the complexity of their influence on gastrointestinal and neuropsychiatric conditions.

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Involvement of Vitamin D3 in the Aging Process According to Sex

Cited by 3 publications

References 43 publications

Is There a Connection between Hyperhomocysteinemia and the Cardiometabolic Syndrome?

Is There a Connection between Hyperhomocysteinemia and the Cardiometabolic Syndrome?

Catecholamine Variations in Pediatric Gastrointestinal Disorders and Their Neuropsychiatric Expression

Variety of Serotonin Levels in Pediatric Gastrointestinal Disorders

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