Involvement of the X chromosome in non-Hodgkin lymphoma

Formation of trisomies and their parental origin in hyperdiploid childhood acute lymphoblastic leukemia

“…The extra X was methylated in one and unmethylated in the other, suggesting that the activation status of the duplicated chromosome has no or little impact in hyperdiploid ALL, a finding similar to what has previously been reported in non-Hodgkin lymphoma with trisomy X. 41 In conclusion, the results of the present study suggest that hyperdiploid childhood ALL originates in a single aberrant mitosis, though a sequential gain of chromosomes other than 21 in consecutive cell divisions remains a possibility. Furthermore, we found no support for the hypothesis that imprinting effects related to the origin of the trisomic/tetrasomic chromosomes are of major pathogenetic importance, with the possible exception of the observed parental skewness of ϩ8 and ϩ14.…”

Formation of trisomies and their parental origin in hyperdiploid childhood acute lymphoblastic leukemia

“…The extra X was methylated in one and unmethylated in the other, suggesting that the activation status of the duplicated chromosome has no or little impact in hyperdiploid ALL, a finding similar to what has previously been reported in non-Hodgkin lymphoma with trisomy X. 41 In conclusion, the results of the present study suggest that hyperdiploid childhood ALL originates in a single aberrant mitosis, though a sequential gain of chromosomes other than 21 in consecutive cell divisions remains a possibility. Furthermore, we found no support for the hypothesis that imprinting effects related to the origin of the trisomic/tetrasomic chromosomes are of major pathogenetic importance, with the possible exception of the observed parental skewness of ϩ8 and ϩ14.…”

X chromosomal abnormalities in basal-like human breast cancer

“…Of note, the presence of two potentially active X chromosomes has been reported in several other human cancers, including non-Hodgkin's lymphomas and germ cell tumors, supporting the possible role of a disorder at Xi in development of malignancy (Kawakami et al, 2003(Kawakami et al, , 2004Looijenga et al, 1997;McDonald et al, 2000;Spatz et al, 2004). Finally, genes that can sometimes escape XCI when located on Xi (Carrel and Willard, 2005) were overrepresented among the overexpressed, X-encoded genes in BLC.…”

Demonstration of the Cell Clonality in Canine Hematopoietic Tumors by X-chromosome Inactivation Pattern Analysis

“…Abnormal hypermethylation of the AR locus has been reported in human lymphoma patients. 21 Moreover, CIARs were found to disagree between CAG-1 and CAG-2 in the 2 lymphoma samples analyzed in this study, which could probably be attributable to the difference in the methylation pattern at the HpaII sites in the CAG-1 and CAG-2 loci. Recently, incomplete correlation was also reported with DNA methylation pattern at the human AR gene and X-chromosome inactivation.…”

Formation of trisomies and their parental origin in hyperdiploid childhood acute lymphoblastic leukemia

“…The extra X was methylated in one and unmethylated in the other, suggesting that the activation status of the duplicated chromosome has no or little impact in hyperdiploid ALL, a finding similar to what has previously been reported in non-Hodgkin lymphoma with trisomy X. 41 In conclusion, the results of the present study suggest that hyperdiploid childhood ALL originates in a single aberrant mitosis, though a sequential gain of chromosomes other than 21 in consecutive cell divisions remains a possibility. Furthermore, we found no support for the hypothesis that imprinting effects related to the origin of the trisomic/tetrasomic chromosomes are of major pathogenetic importance, with the possible exception of the observed parental skewness of ϩ8 and ϩ14.…”

X chromosomal abnormalities in basal-like human breast cancer

“…Of note, the presence of two potentially active X chromosomes has been reported in several other human cancers, including non-Hodgkin's lymphomas and germ cell tumors, supporting the possible role of a disorder at Xi in development of malignancy (Kawakami et al, 2003(Kawakami et al, , 2004Looijenga et al, 1997;McDonald et al, 2000;Spatz et al, 2004). Finally, genes that can sometimes escape XCI when located on Xi (Carrel and Willard, 2005) were overrepresented among the overexpressed, X-encoded genes in BLC.…”

Demonstration of the Cell Clonality in Canine Hematopoietic Tumors by X-chromosome Inactivation Pattern Analysis

“…Abnormal hypermethylation of the AR locus has been reported in human lymphoma patients. 21 Moreover, CIARs were found to disagree between CAG-1 and CAG-2 in the 2 lymphoma samples analyzed in this study, which could probably be attributable to the difference in the methylation pattern at the HpaII sites in the CAG-1 and CAG-2 loci. Recently, incomplete correlation was also reported with DNA methylation pattern at the human AR gene and X-chromosome inactivation.…”

Formation of trisomies and their parental origin in hyperdiploid childhood acute lymphoblastic leukemia

“…The extra X was methylated in one and unmethylated in the other, suggesting that the activation status of the duplicated chromosome has no or little impact in hyperdiploid ALL, a finding similar to what has previously been reported in non-Hodgkin lymphoma with trisomy X. 41 In conclusion, the results of the present study suggest that hyperdiploid childhood ALL originates in a single aberrant mitosis, though a sequential gain of chromosomes other than 21 in consecutive cell divisions remains a possibility. Furthermore, we found no support for the hypothesis that imprinting effects related to the origin of the trisomic/tetrasomic chromosomes are of major pathogenetic importance, with the possible exception of the observed parental skewness of ϩ8 and ϩ14.…”

X chromosomal abnormalities in basal-like human breast cancer

“…Of note, the presence of two potentially active X chromosomes has been reported in several other human cancers, including non-Hodgkin's lymphomas and germ cell tumors, supporting the possible role of a disorder at Xi in development of malignancy (Kawakami et al, 2003(Kawakami et al, , 2004Looijenga et al, 1997;McDonald et al, 2000;Spatz et al, 2004). Finally, genes that can sometimes escape XCI when located on Xi (Carrel and Willard, 2005) were overrepresented among the overexpressed, X-encoded genes in BLC.…”

Demonstration of the Cell Clonality in Canine Hematopoietic Tumors by X-chromosome Inactivation Pattern Analysis

“…Abnormal hypermethylation of the AR locus has been reported in human lymphoma patients. 21 Moreover, CIARs were found to disagree between CAG-1 and CAG-2 in the 2 lymphoma samples analyzed in this study, which could probably be attributable to the difference in the methylation pattern at the HpaII sites in the CAG-1 and CAG-2 loci. Recently, incomplete correlation was also reported with DNA methylation pattern at the human AR gene and X-chromosome inactivation.…”