Involvement of the Ventrolateral Periaqueductal Gray Matter-Central Medial Thalamic Nucleus-Basolateral Amygdala Pathway in Neuropathic Pain Regulation of Rats

Sun, Yi; Wang, Jian; Liang, Shanshan; Ge, Jun; Lu, Ya-Cheng; Li, Jiani; Chen, Yanbing; Luo, Daoshu; Li, Hui; Li, Yunqing

doi:10.3389/fnana.2020.00032

Cited by 21 publications

(19 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, we ran a spectral analysis of cortical EEG FRONT and EEG PAR signals during NREM for both light and dark phase. At day 0, we found a frontal-parietal dissociation of the sigma band (11)(12)(13)(14)(15)(16) presented a decreased in EEG FRONT power in IL Opto-STROKE animals (Normalized power SHAM D0 = 0.06 ± 0.01 µV 2; Opto-STROKE D0 = 0.01 ± 0.01 µV 2 ; twoway ANOVA).…”

Section: Temporal and Topographic Renormalization Of Nrem Sleep And Oscillatory Activities After Ilmentioning

confidence: 88%

“…Together as a functional class (2), these nuclei subserve arousal and various cognitive functions. Specifically, they are involved in the modulation of wake-sleep patterns, sleep oscillations, sensory processing, attention, goaloriented behaviours and associative memory through their substantial connectivity to the cortex (thalamo-cortical), to other thalamic nuclei (intra-thalamic), as well as to other subcortical regions (10)(11)(12)(13)(14)(15)(16). According to their broad system of efferent and afferent projections, the IL have been recognized as higher order thalamic nuclei, involved in higher associative cognitive functions.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Optical mini-stroke of thalamic networks impairs sleep stability, topography and cognition

Lenzi

Borsa

Czekus

et al. 2021

Preprint

View full text Add to dashboard Cite

Modelling stroke in animals remains a challenge for translational research, especially for the infraction of small subcortical arteries. Using combined fibre optics and photothrombosis technologies, we developed a novel model of optically-induced infarcts (Opto-STROKE). Combining our model with electrophysiological recordings in freely-behaving mice, we studied early and late consequent patho-physiological changes in the dynamics of sleep-wake circuits and cognitive performance. Here, focusing on inducing Opto-STROKE lesions in the intralaminar thalamus (IL), which in humans cause severe impairments of arousal, cognition, and affective symptoms, our model recapitulated important deficits on sleep disorders presented in humans including arousal instability, concurrent to an augmented slow-wave activity and a reduction gamma power bands during wakefulness. Moreover, during NREM sleep, spindle density was decreased and topographically shifted to frontal cortices when compared to control animals. Remarkably, gamma power and spindle density were correlated with decreased pain threshold and impaired prefrontal cortex- dependent working memory in Opto-STROKE mice relative to controls. Collectively, our combined method influences both anatomical and functional outcomes of the classical stroke procedures and offers new insights on the fundamental role of the media thalamus as a hub for the regulation of both sleep-wake architecture and cognition.

show abstract

Section: Temporal and Topographic Renormalization Of Nrem Sleep And Oscillatory Activities After Ilmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Optical mini-stroke of thalamic networks impairs sleep stability, topography and cognition

Lenzi

Borsa

Czekus

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Additionally, the rILN are directly innervated by the spinal cord (Wang et al, 1999 ) and the trigeminal nerve (Sato et al, 2020 ). Chemically inhibiting the rILN alleviates behavioral responses to mechanical allodynia (Sun et al, 2020 ) and local activation of 5-HT1A/7 receptors reduces response to tail shock (Harte et al, 2005 ).…”

Section: Functional Attributes Of the Rilnmentioning

confidence: 99%

“…The rILN are hypothesized to mediate the emotional and motivational aspects of pain (Sewards and Sewards, 2002 ) and may potentially do so through reciprocal connectivity with the basolateral and central amygdala (Krettek and Price, 1977 ; Vertes et al, 2012 ; Deng et al, 2020 ; Sun et al, 2020 ). Moreover, μ-opioid receptors are highly expressed in the rILN (Mansour et al, 1994 ).…”

Section: Functional Attributes Of the Rilnmentioning

confidence: 99%

Rostral Intralaminar Thalamus Engagement in Cognition and Behavior

Cover

Mathur

2021

Front. Behav. Neurosci.

View full text Add to dashboard Cite

The thalamic rostral intralaminar nuclei (rILN) are a contiguous band of neurons that include the central medial, paracentral, and central lateral nuclei. The rILN differ from both thalamic relay nuclei, such as the lateral geniculate nucleus, and caudal intralaminar nuclei, such as the parafascicular nucleus, in afferent and efferent connectivity as well as physiological and synaptic properties. rILN activity is associated with a range of neural functions and behaviors, including arousal, pain, executive function, and action control. Here, we review this evidence supporting a role for the rILN in integrating arousal, executive and motor feedback information. In light of rILN projections out to the striatum, amygdala, and sensory as well as executive cortices, we propose that such a function enables the rILN to modulate cognitive and motor resources to meet task-dependent behavioral engagement demands.

show abstract

“…The BT-GO reaction efficiently increases the signal-to-noise ratio; we ( Furuta et al., 2009 ; Kuramoto et al., 2009 ) and others ( Igarashi et al., 2012 ; Sun et al., 2020 ) have applied this method to axonal projection analysis. However, bright-field staining by DAB deposition via the BT-GO reaction has the drawback that the GFP and RFP signals cannot be observed simultaneously in the same section.…”

Section: Limitationsmentioning

confidence: 99%

Exclusive labeling of direct and indirect pathway neurons in the mouse neostriatum by an adeno-associated virus vector with Cre/lox system

et al. 2021

View full text Add to dashboard Cite

Summary We developed an adeno-associated virus (AAV) vector-based technique to label mouse neostriatal neurons comprising direct and indirect pathways with different fluorescent proteins and analyze their axonal projections. The AAV vector expresses GFP or RFP in the presence or absence of Cre recombinase and should be useful for labeling two cell populations exclusively dependent on its expression. Here, we describe the AAV vector design, stereotaxic injection of the AAV vector, and a highly sensitive immunoperoxidase method for axon visualization. For complete details on the use and execution of this protocol, please refer to Okamoto et al. (2020) .

show abstract

Involvement of the Ventrolateral Periaqueductal Gray Matter-Central Medial Thalamic Nucleus-Basolateral Amygdala Pathway in Neuropathic Pain Regulation of Rats

Cited by 21 publications

References 47 publications

Optical mini-stroke of thalamic networks impairs sleep stability, topography and cognition

Optical mini-stroke of thalamic networks impairs sleep stability, topography and cognition

Rostral Intralaminar Thalamus Engagement in Cognition and Behavior

Exclusive labeling of direct and indirect pathway neurons in the mouse neostriatum by an adeno-associated virus vector with Cre/lox system

Contact Info

Product

Resources

About