Involvement of the GABAergic Septo-Hippocampal Pathway in Brain Stimulation Reward

Vega-Flores, Germán; Gruart, Agnès; Delgado‐García, José M.

doi:10.1371/journal.pone.0113787

Cited by 13 publications

(21 citation statements)

References 70 publications

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“…In addition to the effect on nociceptive processing in rACC, KA-induced lesion in the current study also attenuated the conditioned representation of experimental context in dorsal hippocampal field CA1 in the F-CPA task. Indeed, hippocampal neurons process contextual/spatial information, while the septal GABAergic mechanisms are implicated in the mediation of hippocampal-dependent spatial memory tasks 40 41 42 . The preceding, seen in conjunction with the effects of the lesion on rACC and behaviour, suggests that the MSDB may integrate affect with context as part of associative learning in the F-CPA task.…”

Section: Discussionmentioning

confidence: 99%

GABAergic neurons of the medial septum play a nodal role in facilitation of nociception-induced affect

Ang

Lee

Foo

et al. 2015

Sci Rep

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The present study explored the functional details of the influence of medial septal region (MSDB) on spectrum of nociceptive behaviours by manipulating intraseptal GABAergic mechanisms. Results showed that formalin-induced acute nociception was not affected by intraseptal microinjection of bicuculline, a GABAA receptor antagonist, or on selective lesion of septal GABAergic neurons. Indeed, the acute nociceptive responses were dissociated from the regulation of sensorimotor behaviour and generation of theta-rhythm by the GABAergic mechanisms in MSDB. The GABAergic lesion attenuated formalin-induced unconditioned cellular response in the anterior cingulate cortex (ACC) and blocked formalin-induced conditioned place avoidance (F-CPA), and as well as the contextual fear induced on conditioning with brief footshock. The effects of lesion on nociceptive-conditioned cellular responses were, however, variable. Interestingly, the lesion attenuated the conditioned representation of experimental context in dorsal hippocampus field CA1 in the F-CPA task. Collectively, the preceding suggests that the MSDB is a nodal centre wherein the GABAergic neurons mediate nociceptive affect-motivation by regulating cellular mechanisms in ACC that confer an aversive value to the noxious stimulus. Further, in conjunction with a modulatory influence on hippocampal contextual processing, MSDB may integrate affect with context as part of associative learning in the F-CPA task.

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Section: Discussionmentioning

confidence: 99%

GABAergic neurons of the medial septum play a nodal role in facilitation of nociception-induced affect

Ang

Lee

Foo

et al. 2015

Sci Rep

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“…In addition, theta (4–12 Hz) and gamma (60–80 Hz) bands were specifically analyzed. The power spectrum of the hippocampal activity was computed with Spike2 software, using the fast Fourier transform with a Hanning window and expressed as mean power spectrum for each frequency band across the sessions [ 23 , 25 ].…”

Section: Methodsmentioning

confidence: 99%

Impairments of Synaptic Plasticity Induction Threshold and Network Oscillatory Activity in the Hippocampus Underlie Memory Deficits in a Non-Transgenic Mouse Model of Amyloidosis

Mayordomo-Cava

Iborra-Lázaro

Djebari

et al. 2020

Biology

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In early Alzheimer disease (AD) models synaptic failures and upstreaming aberrant patterns of network synchronous activity result in hippocampal-dependent memory deficits. In such initial stage, soluble forms of Amyloid-β (Aβ) peptides have been shown to play a causal role. Among different Aβ species, Aβ25–35 has been identified as the biologically active fragment, as induces major neuropathological signs related to early AD stages. Consequently, it has been extensively used to acutely explore the pathophysiological events related with neuronal dysfunction induced by soluble Aβ forms. However, the synaptic mechanisms underlying its toxic effects on hippocampal-dependent memory remain unresolved. Here, in an in vivo model of amyloidosis generated by intracerebroventricular injections of Aβ25–35 we studied the synaptic dysfunction mechanisms underlying hippocampal cognitive deficits. At the synaptic level, long-term potentiation (LTP) of synaptic excitation and inhibition was induced in CA1 region by high frequency simulation (HFS) applied to Schaffer collaterals. Aβ25–35 was found to alter metaplastic mechanisms of plasticity, facilitating long-term depression (LTD) of both types of LTP. In addition, aberrant synchronization of hippocampal network activity was found while at the behavioral level, deficits in hippocampal-dependent habituation and recognition memories emerged. Together, our results provide a substrate for synaptic disruption mechanism underlying hippocampal cognitive deficits present in Aβ25–35 amyloidosis model.

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“…Although many neuron types in rodent’s hippocampus have been detected and named, however, the role of inhibitory neurons and their high variability is not known. Specially, the balanced excitation and inhibition plays a critical role in neural communication ( Roux and Buzsáki, 2014 ; Vega-Flores et al, 2014 ). In addition, the connectivity rate of different regions of hippocampus is under research as it may play an important role in normal and disorders with hippocampal dysfunction (e.g., Schizophrenia).…”

Section: Discussionmentioning

confidence: 99%

A computational model of pattern separation efficiency in the dentate gyrus with implications in schizophrenia

Faghihi

Moustafa

2015

Front. Syst. Neurosci.

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Information processing in the hippocampus begins by transferring spiking activity of the entorhinal cortex (EC) into the dentate gyrus (DG). Activity pattern in the EC is separated by the DG such that it plays an important role in hippocampal functions including memory. The structural and physiological parameters of these neural networks enable the hippocampus to be efficient in encoding a large number of inputs that animals receive and process in their life time. The neural encoding capacity of the DG depends on its single neurons encoding and pattern separation efficiency. In this study, encoding by the DG is modeled such that single neurons and pattern separation efficiency are measured using simulations of different parameter values. For this purpose, a probabilistic model of single neurons efficiency is presented to study the role of structural and physiological parameters. Known neurons number of the EC and the DG is used to construct a neural network by electrophysiological features of granule cells of the DG. Separated inputs as activated neurons in the EC with different firing probabilities are presented into the DG. For different connectivity rates between the EC and DG, pattern separation efficiency of the DG is measured. The results show that in the absence of feedback inhibition on the DG neurons, the DG demonstrates low separation efficiency and high firing frequency. Feedback inhibition can increase separation efficiency while resulting in very low single neuron’s encoding efficiency in the DG and very low firing frequency of neurons in the DG (sparse spiking). This work presents a mechanistic explanation for experimental observations in the hippocampus, in combination with theoretical measures. Moreover, the model predicts a critical role for impaired inhibitory neurons in schizophrenia where deficiency in pattern separation of the DG has been observed.

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Involvement of the GABAergic Septo-Hippocampal Pathway in Brain Stimulation Reward

Cited by 13 publications

References 70 publications

GABAergic neurons of the medial septum play a nodal role in facilitation of nociception-induced affect

GABAergic neurons of the medial septum play a nodal role in facilitation of nociception-induced affect

Impairments of Synaptic Plasticity Induction Threshold and Network Oscillatory Activity in the Hippocampus Underlie Memory Deficits in a Non-Transgenic Mouse Model of Amyloidosis

A computational model of pattern separation efficiency in the dentate gyrus with implications in schizophrenia

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