Involvement of the dopaminergic system in the consolidation of fear conditioning in hippocampal CA3 subregion

Wen, Jia-Ling; Xue, Li; Wang, Runhua; Chen, Zixiang; Shi, Yan‐Wei; Zhao, Hu

doi:10.1016/j.bbr.2014.10.049

Cited by 18 publications

(16 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These areas receive dopamine input from VTA (Lammel et al 2014 ), and recent evidence indicates that D1 receptor signalling in these regions regulates contextual fear conditioning (Ikegami et al 2014 ). Our results add to a growing body of evidence indicating that contextual fear processing is modulated by both D1- and D2-like receptor signalling (Biojone et al 2011 ; de Souza Caetano et al 2013 ; Colombo et al 2013 ; Wen et al 2014 ).…”

Section: Discussionsupporting

confidence: 72%

Dopamine D1-like receptor signalling in the hippocampus and amygdala modulates the acquisition of contextual fear conditioning

et al. 2015

View full text Add to dashboard Cite

RationaleDopamine D1-like receptor signalling is involved in contextual fear conditioning, but the brain regions involved and its role in other contextual fear memory processes remain unclear.ObjectivesThe objective of this study was to investigate (1) the effects of SCH 23390, a dopamine D1/D5 receptor antagonist, on contextual fear memory encoding, retrieval and reconsolidation, and (2) if the effects of SCH 23390 on conditioning involve the dorsal hippocampus (DH) and/or basolateral amygdala (BLA).MethodsRats were used to examine the effects of systemically administering SCH 23390 on the acquisition, consolidation, retrieval and reconsolidation of contextual fear memory, and on locomotor activity and shock sensitivity. We also determined the effects of MK-801, an NMDA receptor antagonist, on contextual fear memory reconsolidation. The effects of infusing SCH 23390 locally into DH or BLA on contextual fear conditioning and locomotor activity were also examined.ResultsSystemic administration of SCH 23390 impaired contextual fear conditioning but had no effects on fear memory consolidation, retrieval or reconsolidation. MK-801 was found to impair reconsolidation, suggesting that the behavioural parameters used allowed for the pharmacological disruption of memory reconsolidation. The effects of SCH 23390 on conditioning were unlikely the result of any lasting drug effects on locomotor activity at memory test or any acute drug effects on shock sensitivity during conditioning. SCH 23390 infused into either DH or BLA impaired contextual fear conditioning and decreased locomotor activity.ConclusionsThese findings suggest that dopamine D1-like receptor signalling in DH and BLA contributes to the acquisition of contextual fear memory.

show abstract

Section: Discussionsupporting

confidence: 72%

Dopamine D1-like receptor signalling in the hippocampus and amygdala modulates the acquisition of contextual fear conditioning

et al. 2015

View full text Add to dashboard Cite

show abstract

“…On the other hand, the results could be related to how the dHPC and vHPC were microdissected ( Fig 3B), as vHPC slices were richer in CA3 compared to dHPC slices. Obliteration of dopaminergic systems in CA3 has been shown to affect consolidation, but not acquisition of memory (64). We cannot, however, entirely exclude effects on innate fear, but rather suggest the main effect is on memory.…”

Section: Discussionmentioning

confidence: 73%

Deep Brain Stimulation of the Ventromedial Prefrontal Cortex Disrupts Consolidation of Fear Memories

Tan

Poon

Chan

et al. 2019

Preprint

View full text Add to dashboard Cite

Anxiety disorders pose one of the biggest threats to mental health worldwide, yet current therapeutics have been mostly ineffective due to issues with relapse, efficacy, and toxicit. Deep brain stimulation (DBS) is a promising therapy for treatment-resistant psychiatric disorders including anxiety, but very little is known about the effects of DBS on fear memories. In this study, we used a modified plus-maze discriminative and showed that DBS of the ventromedial prefrontal cortex (vmPFC) was able to disrupt consolidation, but not acquisition or retrieval of fear memories. We validated these results using a standard tone-footshock fear conditioning paradigm. We further demonstrated short-term changes in dopaminergic receptor and c-Fos expression in the ventral hippocampus (vHPC) and established a partial casual role of dopamine 2 receptors in this effect. Lastly, we showed changes in neurotransmitter levels in the vHPC. This study highlights the potential therapeutic effect of vmPFC DBS to treat anxiety disorders.

show abstract

“…The dorsal (dorsorostral) VTA, by contrast, projects predominantly to the amygdala, hippocampal formation and entorhinal region (Braak and Del Tredici, 2008 ). We are not disregarding the fact that the hippocampus is involved in the encoding of associative fear memory (Wen et al, 2015 ) and that the former circuit also recruits this structure (Abraham et al, 2014 ), however, the paradigm we implemented in the current study did not include a distinct aversive component, and therefore we assume that encoding of the associative learning experience was mediated by the latter projections from the VTA, thus possibly circumventing an intensive contribution of the nucleus accumbens.…”

Section: Discussionmentioning

confidence: 99%

“…Dose-dependent beneficial and debilitatory effects of receptor antagonism for spatial reference memory have also been described (Setlow and McGaugh, 1999 , 2000 ). This receptor may also be preferentially involved in the processing of aversive memories (Jocham et al, 2014 ; Wen et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Involvement of Dopamine D1/D5 and D2 Receptors in Context-Dependent Extinction Learning and Memory Reinstatement

André

Manahan‐Vaughan

2016

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Dopamine contributes to the regulation of higher order information processing and executive control. It is important for memory consolidation processes, and for the adaptation of learned responses based on experience. In line with this, under aversive learning conditions, application of dopamine receptor antagonists prior to extinction result in enhanced memory reinstatement. Here, we investigated the contribution of the dopaminergic system to extinction and memory reinstatement (renewal) of an appetitive spatial learning task in rodents. Rats were trained for 3 days in a T-maze (context “A”) to associate a goal arm with a food reward, despite low reward probability (acquisition phase). On day 4, extinction learning (unrewarded) occurred, that was reinforced by a context change (“B”). On day 5, re-exposure to the (unrewarded) “A” context took place (renewal of context “A”, followed by extinction of context “A”). In control animals, significant extinction occurred on day 4, that was followed by an initial memory reinstatement (renewal) on day 5, that was, in turn, succeeded by extinction of renewal. Intracerebral treatment with a D1/D5-receptor antagonist prior to the extinction trials, elicited a potent enhancement of extinction in context “B”. By contrast, a D1/D5-agonist impaired renewal in context “A”. Extinction in the “A” context on day 5 was unaffected by the D1/D5-ligands. Treatment with a D2-receptor antagonist prior to extinction had no overall effect on extinction in context “B” or renewal in context “A”, although extinction of the renewal effect was impaired on day 5, compared to controls. Taken together, these data suggest that dopamine acting on the D1/D5-receptor modulates both acquisition and consolidation of context-dependent extinction. By contrast, the D2-receptor may contribute to context-independent aspects of this kind of extinction learning.

show abstract

Involvement of the dopaminergic system in the consolidation of fear conditioning in hippocampal CA3 subregion

Cited by 18 publications

References 59 publications

Dopamine D1-like receptor signalling in the hippocampus and amygdala modulates the acquisition of contextual fear conditioning

Dopamine D1-like receptor signalling in the hippocampus and amygdala modulates the acquisition of contextual fear conditioning

Deep Brain Stimulation of the Ventromedial Prefrontal Cortex Disrupts Consolidation of Fear Memories

Involvement of Dopamine D1/D5 and D2 Receptors in Context-Dependent Extinction Learning and Memory Reinstatement

Contact Info

Product

Resources

About