volume 10, issue 4, P674-688 2018
DOI: 10.18632/aging.101421
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Cemalettin Bekpen, Chen Xie, Almut Nebel, Diethard Tautz

Abstract: The SPATA31 (alias FAM75A) gene family belongs to the core duplicon families that are thought to have contributed significantly to hominoid evolution. It is also among the gene families with the strongest signal of positive selection in hominoids. It has acquired new protein domains in the primate lineage and a previous study has suggested that the gene family has expanded its function into UV response and DNA repair. Here we show that over-expression of SPATA31A1 in fibroblast cells leads to premature senesce…

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