2018
DOI: 10.18632/aging.101421
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Abstract: The SPATA31 (alias FAM75A) gene family belongs to the core duplicon families that are thought to have contributed significantly to hominoid evolution. It is also among the gene families with the strongest signal of positive selection in hominoids. It has acquired new protein domains in the primate lineage and a previous study has suggested that the gene family has expanded its function into UV response and DNA repair. Here we show that over-expression of SPATA31A1 in fibroblast cells leads to premature senesce… Show more

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Cited by 6 publications
(3 citation statements)
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References 45 publications
(64 reference statements)
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“…Functional analysis of cells with reduced SPATA31 copy number showed increased sensitivity to UV exposure [18]. Furthermore, over-expression of SPATA31A1 in epidermal cells leads to premature senescence [43]. Interestingly, long-lived individuals (>96 years old) have significantly fewer copies of SPATA31 genes on average compared to a control group.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Functional analysis of cells with reduced SPATA31 copy number showed increased sensitivity to UV exposure [18]. Furthermore, over-expression of SPATA31A1 in epidermal cells leads to premature senescence [43]. Interestingly, long-lived individuals (>96 years old) have significantly fewer copies of SPATA31 genes on average compared to a control group.…”
Section: Introductionmentioning
confidence: 99%
“…Interestingly, long-lived individuals (>96 years old) have significantly fewer copies of SPATA31 genes on average compared to a control group. This observation suggests that the adaptive evolution of the SPATA31 gene family is an example of antagonistic pleiotropy; it provides a fitness benefit during the reproductive phase of life (better protection against UV-light damage), but it negatively influences overall life span possibly by causing more repair-induced mutations [43]. Knockout of the progenitor gene in mice leads to spermatogenesis defects and infertility [44], which is in line with its testis-specific expression in mice.…”
Section: Introductionmentioning
confidence: 99%
“…SPATA31 gene has been found under strong positive genomic selection. Long-lived individuals carry fewer SPATA31 copy numbers [4]. On the other hand, its overexpression in fibroblast cells leads to premature senescence, this being the case in people having multiple copies of the gene.…”
mentioning
confidence: 99%