Involvement of potassium channels and nitric oxide in tramadol antinociception

Yalçın, İpek; Aksu, Fazilet

doi:10.1016/j.pbb.2004.10.020

Cited by 40 publications

(27 citation statements)

References 38 publications

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“…The mean pretreatment urine volume was 158 ± 32 and 151 ± 28 ml per void in groups 1 and 2, respectively. The mean of urine volume per void was 198 ± 76 and 159 ± 31 ml in the tramadol and placebo groups, respectively (P < 0.001) (95% CI [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. This benefit also continued throughout the treatment period (Figure 2).…”

Section: Resultsmentioning

confidence: 83%

“…Tramadol was superior in increasing mean maximum bladder capacity. The mean maximum bladder capacity at 12 weeks' treatment was 252 ± 98 and 181 ± 56 ml for tramadol and placebo, respectively (P < 0.05) (95% CI [12][13][14][15][16][17][18][19][20][21][22][23][24]. The baseline and 12-week mean maximum pressures of uninhibited detrusor contractions were 46 ± 14, 42 ± 16 cm H 2 O and 31 ± 18, 37 ± 16 cm H 2 O in groups 1 and 2, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…In a rat model of detrusor overactivity due to such changes, tramadol abolished the response to dopamine receptor stimulation [21]. In a recent study it was also found that tramadol normalized detrusor overactivity in middle cerebral arteryoccluded rats [30].…”

Section: Discussionmentioning

confidence: 96%

“…More recently, Yalcin et al . [21] demonstrated that nonspecific voltage-dependent K + channels and nitrergic systems may have a role in the antinociceptive effects of tramadol in hot-plate test in mice.…”

Section: Introductionmentioning

confidence: 99%

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Retracted: Safety and efficacy of tramadol in the treatment of idiopathic detrusor overactivity: a double‐blind, placebo‐controlled, randomized study

Safarinejad

Hosseini

2006

Brit J Clinical Pharma

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AimTo evaluate the efficacy and safety of tramadol in patients with idiopathic detrusor overactivity (IDO). MethodsA total of 76 patients 18 years or older with IDO were randomly assigned to receive 100 mg tramadol sustained release (group 1, n = 38) or placebo (group 2, n = 38) every 12 h for 12 weeks. Clinical evaluation was performed at baseline and every 2 weeks during treatment. All patients underwent urodynamics and ice water test at baseline and 12-week treatment. Main outcome measures were number of voids per 24 h, urine volume per void and episodes of urge incontinence per 24 h on a frequency volume chart and detailed recording of adverse effect. ResultsAfter 12 weeks of treatment mean number of voids per 24 h ± SD decreased from 9.3 ± 3.2 to 5.1 ± 2.1 ( P < 0.001 vs. placebo) [95% confidence interval (CI) − 5.1-− 0.4]. At that time mean urine volume per void increased from 158 ± 32 to 198 ± 76 ml ( P < 0.001 vs. placebo) (95% CI 8-22), while mean number of incontinence episodes per 24 h decreased from 3.2 ± 3.3 to 1.6 ± 2.8 ( P < 0.001 vs. placebo) (95% CI − 2-0.3). Tramadol induced significant improvements in urodynamic parameters. More adverse effects were associated with tramadol treatment than with placebo ( P < 0.05). The main adverse event with tramadol was nausea. ConclusionsIn patients with non-neurogenic IDO tramadol provided beneficial clinical and urodynamic results. Further studies are required to draw final conclusions on the efficacy of this drug in IDO.

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Section: Resultsmentioning

confidence: 83%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Retracted: Safety and efficacy of tramadol in the treatment of idiopathic detrusor overactivity: a double‐blind, placebo‐controlled, randomized study

Safarinejad

Hosseini

2006

Brit J Clinical Pharma

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“…Tramadol has been shown to affect 5-HT 6 , muscarinic 7,8 , nicotinic 9 , NMDA and GABA A 10 receptors. Also, voltage-dependent K + and Na + channels are involved in the antinociceptive and anesthetic effect of tramadol, respectively 11,12 . Limited information about the effects of tramadol on systems other than the central nervous system is available and few studies have compared the effects of tramadol and its enantiomers.…”

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confidence: 99%

Inibição da corrente de cálcio tipo L por tramadol e enantiômeros em miócitos cardíacos de ratos

Medei

Raimundo

Nascimento

et al. 2011

Arq. Bras. Cardiol.

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Peripheral Synergism between Tramadol and Ibuprofen in the Formalin Test

Chavarría‐Bolaños

Pèrez‐Urizar

Grandfils

et al. 2014

Drug Development Research

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Preclinical Research Analgesics with different mechanisms of action can be combined in order to obtain pharmacological synergism, employing lower doses of each agent, thus diminishing side effects. For instance, an atypical dual analgesic such as tramadol (TMD) and a nonsteroidal anti-inflammatory drug such as ibuprofen (IBU) are good candidates to be evaluated when combined and applied peripherally. The present study was conducted to evaluate possible local synergism between TMD and IBU when combined peripherally using the formalin test in rats. The effects of the individual analgesics and their combinations were evaluated simultaneously using a 5% formalin dilution. Dose-effect curves were determined for TMD (50-400 μg/paw) and IBU (1-100 μg/paw). Experimental effective doses were evaluated and isobolographic analyses were constructed to evaluate TMD-IBU combination synergism. Both drugs produced a dose-dependent analgesic effect when applied separately. Isobolographic analysis showed synergism during phase 1 (0-10 min) and phase 2 (15-60 min) when compared with theoretical doses (P < 0.05), with interaction indexes of 0.06 and 0.09, respectively. The present information supports the peripheral analgesic effect of TMD and IBU, especially when combined at appropriate doses.

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Involvement of potassium channels and nitric oxide in tramadol antinociception

Cited by 40 publications

References 38 publications

Retracted: Safety and efficacy of tramadol in the treatment of idiopathic detrusor overactivity: a double‐blind, placebo‐controlled, randomized study

Retracted: Safety and efficacy of tramadol in the treatment of idiopathic detrusor overactivity: a double‐blind, placebo‐controlled, randomized study

Inibição da corrente de cálcio tipo L por tramadol e enantiômeros em miócitos cardíacos de ratos

Peripheral Synergism between Tramadol and Ibuprofen in the Formalin Test

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