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“…src3-null mutant mice have been demonstrated to exhibit decreased development of mammary glands, suggesting that coactivators are critical for efficient proliferation and differentiation of mammary glands (38). Earlier studies also suggested that overexpression of ER coactivators such as SRC1and GRIP enables cell cycle progression (39,40). Even though these studies demonstrated that steroid coactivators enhance normal E 2 -mediated cell cycle progression, the mechanisms by which ER coregulators promote this progression remain elusive.…”
Section: Figmentioning
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“…src3-null mutant mice have been demonstrated to exhibit decreased development of mammary glands, suggesting that coactivators are critical for efficient proliferation and differentiation of mammary glands (38). Earlier studies also suggested that overexpression of ER coactivators such as SRC1and GRIP enables cell cycle progression (39,40). Even though these studies demonstrated that steroid coactivators enhance normal E 2 -mediated cell cycle progression, the mechanisms by which ER coregulators promote this progression remain elusive.…”
Section: Figmentioning
“…For example, increased expression of a member from the transcriptional mediator and intermediary factor proteins TIF2 and CREB-binding protein, and ER-a was observed in intraductal carcinomas of the breast [31], and enhanced expression of steroid receptor RNA activator was associated with mammary tumor progression [32]. Overexpression of SRC-1 potentates cell growth stimulated by E2 in breast cancer cells [33], whereas expression of high levels of SRC-1 in primary breast cancer is associated with a favorable response to tamoxifen in patients with recurrent disease [20]. Ampli®cation or overexpression of peroxisome proliferator±activated receptor binding protein gene is involved in 24±50% of primary breast cancers [15].…”
Section: DI Is Sc Cu Us Ss Si Io On Nmentioning
“…In vitro studies indicate that SRC-1 plays an important role in ER-mediated growth of breast cancer cells. Overexpression of SRC-1 potentiates E2-stimulated growth of MCF-7 breast cancer cells in accordance with an increase in the expression of estrogen-responsive genes (Tai et al, 2000). SRC-1 has also been reported to specifically promote breast cancer metastasis, possibly by promoting migration and invasion by enhancing PEA3 mediated transcriptional activation of Twist, a master regulator of metastasis (Qin et al, 2009).…”
Section: Expression and Functional Role Of Srcs In Breast Tissuementioning