Biochemical Pharmacology volume 80, issue 2, P255-261 2010 DOI: 10.1016/j.bcp.2010.03.025 View full text
Linling Cheng, Qiang You, Hao Yin, Michael P. Holt, Cynthia Ju

Abstract: Drug-induced liver injury (DILI) causes significant patient morbidity and mortality, and is the most common reason for drug withdrawals. It is imperative to gain a thorough understanding of the underlying mechanisms of DILI to effectively predict and prevent these reactions. We have recently developed a murine model of halothane-induced liver injury (HILI). The aim of the present study was to investigate the role of hepatic natural killer T (NKT) cells in the pathogenesis of HILI. The degrees of HILI were com…

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