volume 93, issue 0, P3-P-315 2020
DOI: 10.1254/jpssuppl.93.0_3-p-315
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Abstract: Pulmonary arterial hypertension (PAH) is characterized by pulmonary artery remodeling and inappropriate vasoconstriction, which results in a marked increase in pulmonary arterial pressure and right ventricular hypertrophy. Because a multiple factor participates in the pathogenesis of PAH, elucidation of the further mechanism is needed. Mitochondrial dysfunctions have been reported in the pathogenesis of PAH. In this study, to investigate the involvement of mitochondrial Na + /Ca 2+ exchanger (NCLX) in the deve…

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