Involvement of Inferior Parietal Lobules in Prospective Memory Impairment during Acute MDMA (Ecstasy) Intoxication: An Event-Related fMRI Study

Ramaekers, Johannes G.; Kuypers, Kim P. C.; Wingen, Marleen; Heinecke, Armin; Formisano, Elia

doi:10.1038/npp.2008.219

Cited by 40 publications

(50 citation statements)

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“…GLM analyses revealed that overall, MDMA decreased immediate recall in the WLT, increased the number of prospective memory failures in the prospective memory task and increased localization error in the spatial memory task. These results are fully in line with previous studies that have reported identical memory impairments during intoxication with MDMA Ramaekers, 2005, 2007;Ramaekers et al, 2009), as assessed in identical memory paradigms. These results basically indicate that the current memory paradigms were sensitive to the impairing effects of MDMA and should serve as reliable models to assess changes in MDMAinduced memory impairments after pretreatments with 5-HT 1A and 5-HT 2A receptor blockers, the main goal of this study.…”

Section: Discussionsupporting

confidence: 82%

“…Conditions were separated by minimum washout period of 7 days to avoid cross-condition contamination. The 75 mg dose of MDMA was selected because it falls within the normal range of and has been consistently shown to impair memory performance and produce robust subjective mood changes in a number of previous studies from our lab Ramaekers, 2005, 2007;Kuypers et al, 2006;Ramaekers et al, 2009). Doses of pindolol 20 mg and ketanserin 50 mg represent regular therapeutic doses that block B40% of 5HT 1A receptors and 91% of 5HT 2 receptors, respectively (Brogden and Sorkin, 1990;Rabiner et al, 2000;Sharpley et al, 1994).…”

Section: Treatments and Proceduresmentioning

confidence: 99%

“…Three tests with demonstrated sensitivity (Kuypers and Ramaekers, 2005;Ramaekers et al, 2009) to the impairing effects of MDMA on memory were included in the memorytask battery.…”

Section: Memory Testsmentioning

confidence: 99%

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Blockade of 5-HT2 Receptor Selectively Prevents MDMA-Induced Verbal Memory Impairment

Wel

Kuypers

Theunissen

et al. 2011

Neuropsychopharmacol

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3,4-Methylenedioxymethamphetamine (MDMA) or 'ecstasy' has been associated with memory deficits during abstinence and intoxication. The human neuropharmacology of MDMA-induced memory impairment is unknown. This study investigated the role of 5-HT 2A and 5-HT 1A receptors in MDMA-induced memory impairment. Ketanserin is a 5-HT 2A receptor blocker and pindolol a 5-HT 1A receptor blocker. It was hypothesized that pretreatment with ketanserin and pindolol would protect against MDMA-induced memory impairment. Subjects (N ¼ 17) participated in a double-blind, placebo-controlled, within-subject design involving six experimental conditions consisting of pretreatment (T1) and treatment (T2). T1 preceded T2 by 30 min. T1-T2 combinations were: placebo-placebo, pindolol 20 mg-placebo, ketanserin 50 mg-placebo, placebo-MDMA 75 mg, pindolol 20 mg-MDMA 75 mg, and ketanserin 50 mg-MDMA 75 mg. Memory function was assessed at Tmax of MDMA by means of a word-learning task (WLT), a spatial memory task and a prospective memory task. MDMA significantly impaired performance in all memory tasks. Pretreatment with a 5-HT 2A receptor blocker selectively interacted with subsequent MDMA treatment and prevented MDMA-induced impairment in the WLT, but not in the spatial and prospective memory task. Pretreatment with a 5-HT 1A blocker did not affect MDMA-induced memory impairment in any of the tasks. Together, the results demonstrate that MDMA-induced impairment of verbal memory as measured in the WLT is mediated by 5-HT 2A receptor stimulation.

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Section: Discussionsupporting

confidence: 82%

Section: Treatments and Proceduresmentioning

confidence: 99%

See 1 more Smart Citation

Blockade of 5-HT2 Receptor Selectively Prevents MDMA-Induced Verbal Memory Impairment

Wel

Kuypers

Theunissen

et al. 2011

Neuropsychopharmacol

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“…Prospective memory task (PMT) The PMT was developed to examine prospective memory performance (Ramaekers et al 2009b). The subjects were shown the letter A or B in the middle of a computer screen.…”

Section: Performance Testsmentioning

confidence: 99%

Rivastigmine but not vardenafil reverses cannabis-induced impairment of verbal memory in healthy humans

et al. 2014

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“…Furthermore, reduced activity in areas of the parietal cortex, following acute MDMA administration, was shown to be directly associated with impaired PM performance (Ramaekers et al 2009). …”

Section: Discussionmentioning

confidence: 99%

Prospective memory deficits in illicit polydrug users are associated with the average long-term typical dose of ecstasy typically consumed in a single session.

Gallagher¹,

Hadjiefthyvoulou²,

Fisk³

et al. 2014

Neuropsychology

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Prospective memory deficits in illicit polydrug users are associated with the average long term typical dose of ecstasy typically consumed in a single session. AbstractRationale Neuroimaging evidence suggests that ecstasy-related reductions in SERT densities relate more closely to the number of tablets typically consumed per session rather than estimated total lifetime use. In order to better understand the basis of drug related deficits in prospective memory (PM) we explored the association between PM and average long-term typical dose and long-term frequency of use. Method Study 1: Sixty five ecstasy/polydrug users and 85 non-ecstasy users completed an event based, a short-term and a long-term time based PM task. Study 2: Study 1 data were merged with outcomes on the same PM measures from a previous study creating a combined sample of 103 ecstasy/polydrug users, 38 cannabis-only users and 65 nonusers of illicit drugs. Results Study 1: Ecstasy/polydrug users had significant impairments on all PM outcomes compared to non-ecstasy users. Study 2:Ecstasy/polydrug users were impaired in event based PM compared to both other groups and in long-term time based PM compared to non illicit drug users. Both drug using groups did worse on the short-term time based PM task compared to nonusers. Higher long-term average typical dose of ecstasy was associated with poorer performance on the event and short-term time based PM tasks and accounted for unique variance in the two PM measures over and above the variance associated with cannabis and cocaine use. Conclusions The typical ecstasy dose consumed in a single session is an important predictor of PM impairments with higher doses reflecting increasing tolerance giving rise to greater PM impairment.

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Involvement of Inferior Parietal Lobules in Prospective Memory Impairment during Acute MDMA (Ecstasy) Intoxication: An Event-Related fMRI Study

Cited by 40 publications

References 50 publications

Blockade of 5-HT2 Receptor Selectively Prevents MDMA-Induced Verbal Memory Impairment

Blockade of 5-HT2 Receptor Selectively Prevents MDMA-Induced Verbal Memory Impairment

Rivastigmine but not vardenafil reverses cannabis-induced impairment of verbal memory in healthy humans

Prospective memory deficits in illicit polydrug users are associated with the average long-term typical dose of ecstasy typically consumed in a single session.

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