volume 93, issue 0, P2-YIA-55 2020
DOI: 10.1254/jpssuppl.93.0_2-yia-55
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Abstract: Temporal lobe epilepsy (TLE) is the most common form of epilepsy. The hippocampus, located in the mesial temporal lobe, is implicated in the development of TLE. However, mechanisms underlying hippocampal epileptogenesis in TLE remain unclear. Here, we investigated whether ocular albinism 1 gene product (GPR143), which is highly expressed in the hippocampus, is involved in hippocampal epileptogenesis in TLE. We induced limbic seizures by administration of kainic acid. We found that seizure scores reduced in Gpr…

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