Involvement of dopamine D2 and glutamate NMDA receptors in the antidepressant-like effect of amantadine in mice

Raupp-Barcaro, Inara F.; Dias, Isabella Caroline da Silva; Meyer, Erika; Vieira, Jeane Cristina Fonseca; Pereira, Giovana da Silva; Petkowicz, Arthur Ribeiro; Oliveira, Rúbia Maria Weffort de; Andreatini, Roberto

doi:10.1016/j.bbr.2021.113443

Cited by 4 publications

(2 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Amantadine is believed to activate presynaptic dopamine receptor D2 reducing the dopamine transporter related to dopamine reuptake [ 19 ]. In animal studies, amantadine inhibited monoamine oxidase B, decreasing dopamine degradation [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Myoclonus Secondary to Amantadine: Case Report and Literature Review

Rissardo

Caprara

2023

Clinics and Practice

View full text Add to dashboard Cite

The usual adverse events of amantadine are dizziness, dry mouth, and peripheral edema. Postmarketing experience has revealed abnormal movements such as tremors, involuntary muscle contractions, and gait abnormalities. Herein, we report a case of an elderly male who presented with generalized twitching associated with amantadine. A 64-year-old male presenting with jerking movements within one day of onset was admitted. Sudden and involuntary distal lower and upper limb muscle twitching was observed. The subject presented subsequent brief movements when attempting to stand or hold arms antigravity. He was diagnosed with Parkinson’s disease three years ago. Eight days before the presentation to the emergency department, he consulted with his primary care physician, who prescribed amantadine to improve his motor symptoms. On the seventh day, he developed brisk abnormal movements. Laboratory exams, neuroimaging, and electroencephalogram were unremarkable. Amantadine was discontinued. After three days, the patient reported that his jerking movements had fully recovered. To the authors’ knowledge, 22 individuals with amantadine-associated myoclonus had already been reported in the literature. The pathophysiology of amantadine-induced myoclonus is probably related to serotoninergic pathways. Myoclonus secondary to amantadine was slightly more common in men. The population affected was elderly, with a mean and median age of 67.7 and 64 years.

show abstract

Section: Discussionmentioning

confidence: 99%

Myoclonus Secondary to Amantadine: Case Report and Literature Review

Rissardo

Caprara

2023

Clinics and Practice

View full text Add to dashboard Cite

show abstract

“…When interpreting the effect of amantadine, it should be taken into account that it is also an NMDA glutamate receptor antagonist (Raupp-Barcaro et al, 2021 ).…”

Section: Prepulse Inhibition Of the Startle Reactionmentioning

confidence: 99%

Comparative Analysis of Dopaminergic and Cholinergic Mechanisms of Sensory and Sensorimotor Gating in Healthy Individuals and in Patients With Schizophrenia

Proshin

2022

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Sensory and sensorimotor gating provide the early processing of information under conditions of rapid presentation of multiple stimuli. Gating deficiency is observed in various psychopathologies, in particular, in schizophrenia. However, there is also a significant proportion of people in the general population with low filtration rates who do not show any noticeable cognitive decline. The review article presents a comparative analysis of existing data on the peculiarities of cholinergic and dopaminergic mechanisms associated with lowering gating in healthy individuals and in patients with schizophrenia. The differences in gating mechanisms in cohorts of healthy individuals and those with schizophrenia are discussed.

show abstract