2016
DOI: 10.18632/aging.100909 View full text |Buy / Rent full text
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Abstract: The ability to appropriately respond to proteotoxic stimuli is a major determinant of longevity and involves induction of various heat shock response (HSR) genes, which are essential to cope with cellular and organismal insults throughout lifespan. The activity of NAD+-dependent deacetylase Sir2, originally discovered in yeast, is known to be essential for effective HSR and longevity. Our previous work on HSR in Daphnia pulicaria indicated a drastic reduction of the HSR in older organisms. In this report we in… Show more

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“…Part of an explanation may be that stresses influencing parameters such as reactive oxygen species (ROS), chaperon protein regulation, autophagy, and the accumulation of senescent cells affect tissues throughout the organism ( 90 92 ). However, the network of mutual dependencies may also cause correlation between resilience of the parts, as the malfunctioning of one subsystem (e.g., glucose regulation) can raise the stress on other subsystems (e.g., water balance by increased urinary output, cognition by glycation of proteins), causing them to deteriorate also.…”
Section: Resilience Of the Networkmentioning
“…Results obtained in a recent study using rotifers suggested that multiple pathways are involved in temperature mediated life extension, among them a complex signaling cascade regulated by a sensory receptor (Johnston & Snell, 2016). In Daphnia, temperature changes patterns of heat shock protein expression in a sex-specific manner (Mikulski et al, 2011), which may have consequences for their lifespans (Schumpert, Anderson, Dudycha, & Patel, 2016). Temperature thus exerts its effects not only via passive thermodynamics, but also via differential modulation of gene expression, and these effects are subject to selection and underlie adaptation.…”
Section: Discussionmentioning
“…In the waterfleas Daphnia pulex, Daphnia melanica and Daphnia pulicaria, successful RNAi was achieved by adding bacteria expressing Daphnia-specific dsRNA to the aquatic medium containing the animals. Semi-quantitative transcript analysis, as well as phenotypical observations, suggest an efficient knockdown using this method (Schumpert et al, 2016;.…”
Section: Crustaceamentioning
“…Moreover, SIR2 is involved in lifespan determination and calorie restriction in yeast mother cells, and its activity is increased by calorie restriction in yeast (Lin et al, 2002). Considering that the lifespans of the strains lacking SIR2, 3, and 4 are short, the activity associated with SIR2 is known to be essential for longevity in yeast (Kaeberlein et al, 1999;Schumpert et al, 2016). It remains uncertain whether UPE has activity other than SIR action.…”
Section: Figurementioning
“…While microarray studies of consumer responses to dietary variation could be done in the absence of genomic data for the resource (e.g., [ 41 ]), the shift to NextGen sequencing for transcriptomics will require bioinformatic approaches to distinguish responses of the consumer from those of the consumed. The advent of feeding-based functional genetics for Daphnia [ 42 , 43 ] will also benefit from better understanding of the genetics of algae used for basic diets.…”
Section: Introductionmentioning