Involvement of cell adhesion and activation molecules in the pathogenesis of erythema dyschromicum perstans (ashy dermatitis). The effect of clofazimine therapy

Erythema Discromicum Perstans Related with Oral Contraceptive and Progesterone Injections

“…In fact, the biopsy evaluation is primarily used to rule out other diagnoses including drug eruptions, lichen planus as to confirm that of EDP (1,2).. Similar to that seen in our patient, the histological findings include mild basal cell layer vacuolar degeneration overlying an upper dermis with a mild perivascular mononuclear cell infiltrate and increased melanophage (1,2,4,7). EDP may be viewed as originating at an early stage as an inflammatory reaction to an ingested agent or contactant or a chemical, followed by a progressive persistent hyperpigmentation (1).…”

“…EDP may be viewed as originating at an early stage as an inflammatory reaction to an ingested agent or contactant or a chemical, followed by a progressive persistent hyperpigmentation (1). In the literature, EDP has been linked with a number of conditions including endocrinopathies, nematode infestations, pesticide exposure, human immunodeficiency virus and chronic hepatitis C infections, ammonium nitrate consumption, cobalt allergy, radiological contrast material, and medications such as oral antibiotics, benzodiazepine, omeprazole (1)(2)(3)(4)(5)(6)(7)(8)(9).…”

“…It typically occurs in the second decade of life and generally affects those with skin phototype IV (2)(3)(4)(5)(6)(7)(8). The etiology of EDP is unknown but associations with endocrinopathies, infestations, infections, and drug allergies have been reported (2)(3)(4)(5)(6)(7)(8)(9).…”

Ashy dermatosis: A comprehensive review

“…The patients were given tablet clofazimine 100mg daily for 3 months [31,32]. The response rates varied from 66% to 87%.…”

A Case of Unilateral Ashy Dermatosis

“…Recently, clofazimine has been used with some success in adults, apparently because of its anti-inflammatory and immunomodulating effects 9 . A successful response to dapsone in one patient has also been reported 10 .…”