Involvement of Ca2+ and ROS signals in nickel-impaired human sperm function

Chen, Chen; Li, Bingqian; Huang, Rongzu; Dong, Shijue; Zhou, Yang; Song, Jian; Zeng, Xuhui; Zhang, Xiaoning

doi:10.1016/j.ecoenv.2022.113181

Cited by 8 publications

(7 citation statements)

References 56 publications

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“…An elevated concentration of Ni in bull semen may be accompanied by pathological modifications of spermatozoa morphology [ 50 ]. Nickel also interferes with intracellular Ca 2+ signalling, leading to impaired motility and excessive OS [ 51 ]. However, despite the concentration of 2.50 mg/kg detected in the present work, no association was determined by performed correlation analysis.…”

Section: Discussionmentioning

confidence: 99%

Sperm Quality Affected by Naturally Occurring Chemical Elements in Bull Seminal Plasma

et al. 2022

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This study monitored the chemical and biochemical composition of bovine seminal plasma (SP). Freshly ejaculated semen (n = 20) was aliquoted into two parts. The first aliquot was immediately assessed to determine the sperm motion parameters. Another motility measurement was performed following an hour-long co-incubation of spermatozoa with SP at 6 °C. The other aliquot was processed to obtain the SP. Seminal plasma underwent the analyses of chemical composition and quantification of selected proteins, lipids and RedOx markers. Determined concentrations of observed parameters served as input data to correlation analyses where associations between micro and macro elements and RedOx markers were observed. Significant correlations of total oxidant status were found with the content of Cu and Mg. Further significant correlations of glutathione peroxidase were detected in relation to Fe and Hg. Furthermore, associations of chemical elements and RedOx markers and spermatozoa quality parameters were monitored. The most notable correlations indicate beneficial effects of seminal Fe on motility and Mg on velocity and viability of spermatozoa. On the contrary, negative correlations were registered between Zn and sperm velocity and seminal cholesterol content and motility. Our findings imply that seminal plasma has a prospective to be developed as the potential biomarker of bull reproductive health.

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Section: Discussionmentioning

confidence: 99%

Sperm Quality Affected by Naturally Occurring Chemical Elements in Bull Seminal Plasma

et al. 2022

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“…A previous study conducted in Jordan on male rats for sixty days found that there was a dose-dependent decrease in [108,109]. Celery can reduce fertility and the number of offspring, according to the findings of another study that was carried out in Iran [108]. This finding suggests that celery could be an effective natural medicinal plant option for the prevention of pregnancy.…”

Section: Apium Graveolens Apiaceaementioning

confidence: 92%

“…Celery is also known as "Krufs" in Jordan. A previous study conducted in Jordan on male rats for sixty days found that there was a dose-dependent decrease in [108,109]. Celery can reduce fertility and the number of offspring, according to the findings of another study that was carried out in Iran [108].…”

Section: Apium Graveolens Apiaceaementioning

confidence: 92%

Role of Antioxidants of Natural Herbs in Management of Male Infertility

Gaznee¹,

Kohli²,

Kumar³

2023

J. Res. Appl. Sci. Biotechnol.

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If you and your spouse have been trying to conceive for a year and neither of you has been successful, there is a possibility that you are one of the 50–80 million people throughout the world who struggle with infertility. There is a male component present in approximately 20%-30% of these instances. It is common knowledge that low-quality sperm and oxidative stress (OS) both have a role in the aetiology of male infertility. Because of the oxidation of DNA, proteins, and lipids, excessive levels of reactive oxygen species (ROS) have the potential to disrupt the viability, motility, and morphology of sperm cells. ROS are responsible for these changes. Methods: Through the use of the PubMed interface, we searched the MEDLINE database for studies that had been completed and published during the past ten years that analysed the effect that antioxidants had on sperm in infertile guys (2012–2022). A number of different phrases, including infertility, alpha-lipoic acid, zinc, folate, coenzyme Q10, selenium, and vitamin, were utilised during the search. The study's findings indicate that inositol serves a purpose in a number of different mechanisms that foster contacts between sperm and oocytes, and that it also affects OS levels in sperm cells by way of its engagement in mitochondrial events. Alpha-lipoic acid (ALA) lessens the damage caused by reactive oxygen species (ROS) and improves the quality of sperm in a number of ways, including motility, morphology, and count. There might be a connection between not getting enough zinc in your diet and having low-quality sperm. Zinc and folate are two nutrients that can boost the quantity and quality of sperm. When taken orally, coenzyme Q10 increases the number of sperm as well as their overall motility and forward movement. A therapy with selenium (Se) results in an improvement in the sperm's overall quality, and this improvement is connected with an increase in ejaculatory production. Only vitamin B12 has been found to improve the quality of sperm; it does this by boosting sperm count and motility and by decreasing sperm DNA damage. Vitamin B12 is the only vitamin that has been proved to do this. Conclusions: Dietary supplementation with antioxidants may improve sperm quality in men with low-quality semen by reducing OS-induced sperm damage and increasing hormone synthesis and spermatozoa concentration, motility, and morphology. This may be achieved in men who also have low levels of antioxidants in their semen. Antioxidants can exert their effects in a variety of ways; hence, it is important for researchers conducting future clinical trials to study the possibility of combining a number of antioxidants.

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“…In the seminal plasma of jackasses, the activities of antioxidant enzymes (SOD, CAT, GPX, and GSR) were significantly correlated with sperm motility and forward movement ability (Maehly and Chance, 1954;Wdowiak et al, 2015;Papas et al, 2019). The impairment by NiCl 2 treatment on sperm total motility and progressive motility in a dose-and timedependent manner is characterized by interference with Ca 2+ signaling and elevated levels of ROS and malondialdehyde, which can be rescued by the antioxidants N-acetyl-L-cysteine or tocopherol (Chen et al, 2022). These studies indicate that antioxidant enzymes in the sperm storage organ play a strong protective role against OS ensuring maintenance of sperm vitality and overall quality.…”

Section: The Role Of Ros In Sperm Functions and Testis Healthmentioning

confidence: 98%

Effects of reactive oxygen species and mitochondrial dysfunction on reproductive aging

Song,

Xiao,

Zhang

et al. 2024

Front. Cell Dev. Biol.

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Mitochondria, the versatile organelles crucial for cellular and organismal viability, play a pivotal role in meeting the energy requirements of cells through the respiratory chain located in the inner mitochondrial membrane, concomitant with the generation of reactive oxygen species (ROS). A wealth of evidence derived from contemporary investigations on reproductive longevity strongly indicates that the aberrant elevation of ROS level constitutes a fundamental factor in hastening the aging process of reproductive systems which are responsible for transmission of DNA to future generations. Constant changes in redox status, with a pro-oxidant shift mainly through the mitochondrial generation of ROS, are linked to the modulation of physiological and pathological pathways in gametes and reproductive tissues. Furthermore, the quantity and quality of mitochondria essential to capacitation and fertilization are increasingly associated with reproductive aging. The article aims to provide current understanding of the contributions of ROS derived from mitochondrial respiration to the process of reproductive aging. Moreover, understanding the impact of mitochondrial dysfunction on both female and male fertility is conducive to finding therapeutic strategies to slow, prevent or reverse the process of gamete aging, and thereby increase reproductive longevity.

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Involvement of Ca2+ and ROS signals in nickel-impaired human sperm function

Cited by 8 publications

References 56 publications

Sperm Quality Affected by Naturally Occurring Chemical Elements in Bull Seminal Plasma

Sperm Quality Affected by Naturally Occurring Chemical Elements in Bull Seminal Plasma

Role of Antioxidants of Natural Herbs in Management of Male Infertility

Effects of reactive oxygen species and mitochondrial dysfunction on reproductive aging

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