volume 89, issue 11, P1783-1794 2011
DOI: 10.1002/jnr.22691
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Rumi Uchibayashi, Kazuhiro Tsuruma, Yuta Inokuchi, Masamitsu Shimazawa, Hideaki Hara

Abstract: Endoplasmic reticulum (ER) stress and oxidative stress are involved in many diseases, including retinal disorders, causing toxicity in various tissues and cells; however, intracellular signaling of ER stress and cross-talk between ER stress and oxidative stress are unknown in retinal ganglion cells (RGC), whose degeneration is associated with glaucoma. The aim of the study was to clarify the mechanisms of ER stress- and oxidative stress-induced RGC death, using cultured retinal ganglion cells (RGC-5) in vitro …

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